scholarly journals Validation of low‐dose aspirin prescription data in The Health Improvement Network: how much misclassification due to over‐the‐counter use?

2015 ◽  
Vol 25 (4) ◽  
pp. 392-398 ◽  
Author(s):  
Lucía Cea Soriano ◽  
Montse Soriano‐Gabarró ◽  
Luis A. García Rodríguez
Keyword(s):  
Low Dose ◽  
Health Improvement ◽  
Prescription Data ◽  
Over The Counter ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
The Health Improvement Network

scholarly journals Incidence of intracranial bleeds in new users of low-dose aspirin: a cohort study using The Health Improvement Network

2017 ◽  
Vol 15 (6) ◽  
pp. 1055-1064 ◽  
Author(s):  
L. Cea Soriano ◽  
D. Gaist ◽  
M. Soriano-Gabarró ◽  
L. A. García Rodríguez
Keyword(s):  
Cohort Study ◽  
Low Dose ◽  
Health Improvement ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
The Health Improvement Network

Thromboxane inhibition during concurrent therapy with low-dose aspirin and over-the-counter naproxen sodium

2017 ◽  
Vol 45 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Paul A. Gurbel ◽  
Kevin P. Bliden ◽  
Junhong Zhu ◽  
Emanuel Troullos ◽  
Robert Centofanti ◽  
...  
Keyword(s):  
Naproxen Sodium ◽  
Low Dose ◽  
Over The Counter ◽  
Concurrent Therapy ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Alert Issued on Low-Dose Aspirin + Ibuprofen

2006 ◽  
Vol 34 (10) ◽  
pp. 8
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Investigation of the Interaction of Blood Platelets with the Coagulation System at the Site of Plug Formation In Vivo in Man - Effect of Low-Dose Aspirin

1987 ◽  
Vol 57 (01) ◽  
pp. 062-066 ◽  
Author(s):  
P A Kyrle ◽  
J Westwick ◽  
M F Scully ◽  
V V Kakkar ◽  
G P Lewis
Keyword(s):  
Platelet Activation ◽  
Thrombin Generation ◽  
Low Dose ◽  
Bleeding Time ◽  
Blood Platelets ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Plug Formation ◽  
Granule Release

SummaryIn 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, α-granule release (represented by β-thromboglobulin [βTG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug formation, considerable platelet activation and thrombin generation were seen within the first minute, as indicated by a 110-fold, 50-fold and 30-fold increase of FPA, TxB2 and PTG over the corresponding plasma values. After a further increase of the markers in the subsequent 3 minutes, they reached a plateau during the fourth and fifth minute. A low-dose aspirin regimen (0.42 mg.kg-1.day-1 for 7 days) caused >90% inhibition of TxB2formation in both bleeding time blood and clotted blood. At the site of plug formation, a-granule release was substantially reduced within the first three minutes and thrombin generation was similarly inhibited. We conclude that (a) marked platelet activation and considerable thrombin generation occur in the early stages.of haemostasis, (b) α-granule release in vivo is partially dependent upon cyclo-oxygenase-controlled mechanisms and (c) thrombin generation at the site of plug formation is promoted by the activation of platelets.

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