Pancreatic exocrine dysfunction: common in type 3c diabetes, but don't forget types 1 and 2 diabetes mellitus

2017 ◽  
Vol 34 (6) ◽  
pp. 200-204a
Author(s):  
Katherine Alington ◽  
Michael H Cummings
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Exocrine ◽  
Pancreatic Exocrine Dysfunction ◽  
Exocrine Dysfunction

Re: Relationship between the severity of diabetes mellitus and pancreatic exocrine dysfunction

1985 ◽  
Vol 1 (5) ◽  
pp. 303-304
Author(s):  
P. Dandona ◽  
V.A. Fonseca ◽  
D. Junglee ◽  
A. Katrak ◽  
D.P. Mikhailidis
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Exocrine ◽  
Pancreatic Exocrine Dysfunction ◽  
Exocrine Dysfunction

Correlation Between Bile Acid Malabsorption and Pancreatic Exocrine Dysfunction in Patients with Chronic Pancreatitis

Pancreas ◽  
1994 ◽  
Vol 9 (5) ◽  
pp. 580-584 ◽  
Author(s):  
Teruo Nakamura ◽  
Hiroaki Kikuchi ◽  
Kazuo Takebe ◽  
Masataka Ishii ◽  
Ken-ichi Imamura ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Bile Acid ◽  
Bile Acid Malabsorption ◽  
Pancreatic Exocrine ◽  
Pancreatic Exocrine Dysfunction ◽  
Exocrine Dysfunction

Pancreatic exocrine dysfunction in a model of spontaneous type I diabetes

1998 ◽  
Vol 114 ◽  
pp. A467
Author(s):  
J.A. Hardin ◽  
J. Fung ◽  
L. Donegan ◽  
D.G. Gall
Keyword(s):  
Type I Diabetes ◽  
Type I ◽  
Pancreatic Exocrine ◽  
Pancreatic Exocrine Dysfunction ◽  
Exocrine Dysfunction

scholarly journals Diabetes and Pancreatic Exocrine Dysfunction Due to Mutations in the Carboxyl Ester Lipase Gene-Maturity Onset Diabetes of the Young (CEL-MODY)

2011 ◽  
Vol 286 (40) ◽  
pp. 34593-34605 ◽  
Author(s):  
Bente B. Johansson ◽  
Janniche Torsvik ◽  
Lise Bjørkhaug ◽  
Mette Vesterhus ◽  
Anja Ragvin ◽  
...  
Keyword(s):  
Maturity Onset Diabetes ◽  
Lipase Gene ◽  
Onset Diabetes ◽  
Pancreatic Exocrine ◽  
Pancreatic Exocrine Dysfunction ◽  
Exocrine Dysfunction

scholarly journals Long-Term Outcome and Treatment in Persistent and Transient Congenital Hyperinsulinism: A Finnish Population-Based Study

2021 ◽  
Author(s):  
Jonna M E Männistö ◽  
Jarmo Jääskeläinen ◽  
Timo Otonkoski ◽  
Hanna Huopio
Keyword(s):  
21St Century ◽  
Population Based ◽  
Congenital Hyperinsulinism ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Live Births ◽  
Pancreatic Exocrine ◽  
Pancreatic Exocrine Dysfunction ◽  
Exocrine Dysfunction

Abstract Context The management of congenital hyperinsulinism (CHI) has improved. Objective To examine the treatment and long-term outcome of Finnish patients with persistent and transient CHI (P-CHI and T-CHI). Design A population-based retrospective study of CHI patients treated from 1972 to 2015. Patients 106 patients with P-CHI and 132 patients with T-CHI (in total, 42 diagnosed before and 196 after year 2000) with median follow-up durations of 12.5 and 6.2 years, respectively. Main Outcome Measures Recovery, diabetes, pancreatic exocrine dysfunction, neurodevelopment. Results The overall incidence of CHI (n = 238) was 1:11 300 live births (1972-2015). From 2000 to 2015, the incidence of P-CHI (n = 69) was 1:13 500 and of T-CHI (n = 127) 1:7400 live births. In the 21st century P-CHI group, hyperinsulinemic medication was initiated and normoglycemia achieved faster relative to earlier. Of the 74 medically treated P-CHI patients, 68% had discontinued medication. Thirteen (12%) P-CHI patients had partial pancreatic resection and 19 (18%) underwent near-total pancreatectomy. Of these, 0% and 84% developed diabetes and 23% and 58% had clinical pancreatic exocrine dysfunction, respectively. Mild neurological difficulties (21% vs 16%, respectively) and intellectual disability (9% vs 5%, respectively) were as common in the P-CHI and T-CHI groups. However, the 21st century P-CHI patients had significantly more frequent normal neurodevelopment and significantly more infrequent diabetes and pancreatic exocrine dysfunction compared with those diagnosed earlier. Conclusions Our results demonstrated improved treatment and long-term outcome in the 21st century P-CHI patients relative to earlier.

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