Successful use of family-based therapy interventions for uncontrolled type 1 diabetes in an adolescent

2017 ◽  
Vol 34 (3) ◽  
pp. 95-98 ◽  
Author(s):  
Robert P Wilfahrt ◽  
Abigail Matthews ◽  
Katrina R Lenz ◽  
Leslie A Sim
Keyword(s):  
Type 1 Diabetes ◽  
Family Based ◽  
Therapy Interventions ◽  
Family Based Therapy

scholarly journals Maternal smoking during pregnancy and type 1 diabetes in the offspring: A nationwide register-based study with family-based designs

2022 ◽  
Author(s):  
Yuxia Wei ◽  
Tomas Andersson ◽  
Jessica Edstorp ◽  
Josefin E. Lofvenborg ◽  
Mats Talback ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Maternal Smoking ◽  
Full Cohort ◽  
Smoking During Pregnancy ◽  
Medical Birth Register ◽  
Quasi Experimental ◽  
Maternal Smoking During Pregnancy ◽  
Family Based ◽  
Cousin Comparison

Objectives: Maternal smoking during pregnancy is associated with a reduced risk of type 1 diabetes (T1D) in the offspring. We investigated whether this association is consistent with a causal interpretation by accounting for familial (shared genetic and environmental) factors using family-based, quasi-experimental designs. Design: A nationwide, prospective cohort study and a nested case-control study (quasi-experiment) comparing children with T1D to their age-matched siblings (or cousins). Setting: Swedish national registers. Participants: We included 2,995,321 children born in Sweden between 1983 and 2014. Exposure: Information on maternal smoking during pregnancy was retrieved from the Swedish Medical Birth Register. Main outcome measures: Children were followed for a diagnosis of T1D until 2020 through the National Patient, Diabetes and Prescribed Drug Registers. Results: A total of 18,617 children developed T1D, with a median age at diagnosis of 9.4 years. The sibling and cousin comparison design included 14,284 and 7,988 of these children, respectively. Maternal smoking during pregnancy was associated with a 22% lower risk of offspring T1D in the full cohort (hazard ratio: 0.78, 95% confidence interval [CI]: 0.75 to 0.82) in the multivariable-adjusted model. The corresponding odds ratio was 0.78 (95% CI: 0.69 to 0.88) in the sibling and 0.72 (95% CI: 0.66 to 0.79) in the cousin comparison analysis. Conclusions: This nationwide, family-based study provides support for a protective effect of maternal smoking on offspring T1D. Mechanistic studies are needed to elucidate the underlying pathways behind this link.

Association of HLA Class II Alleles and Haplotypes with Type 1 Diabetes in Tunisian Arabs

2018 ◽  
Vol 127 (10) ◽  
pp. 653-662
Author(s):  
Abdelhafidh Hajjej ◽  
Wassim Y. Almawi ◽  
Mouna Stayoussef ◽  
Lasmar Hattab ◽  
Slama Hmida
Keyword(s):  
Type 1 Diabetes ◽  
Association Studies ◽  
Class Ii ◽  
Correlation Study ◽  
Case Control ◽  
Linkage Study ◽  
Hla Class Ii ◽  
Racial Background ◽  
Family Based

AbstractThe molecular association of HLA class II with type 1 diabetes (T1DM) was investigated in Tunisian Arabs using 3 kinds of analyses. The first was a case-control association study, using Relative Predispositional Effects method, involved 137 T1DM cases and 258 control subjects. The second was family-based association-linkage study, using Transmission Disequilibrium Test, and covering 50 Tunisian families comprising 73 T1DM patients and 100 parents. The third was a wide correlation study between 4 DRB1 alleles (DRB1*03, *04, *11, *15) and T1DM in 52 countries, using Spearman’s Rho. Results from Case-control and family-based association studies showed that DRB1*03 and DRB1*04 alleles predispose to T1DM in Tunisian Arabs. Conversely, only DRB1*11 was protective for T1DM. DRB1*04-DQB1*03 haplotype was consistently associated positively with T1DM; DRB1*03/DRB1*04 genotype had the highest risk of T1DM development. Compared to DRB1*03, HLA-DRB1*04 was associated with higher T1DM incidence. Thus, the contribution of HLA class II to T1DM genetic susceptibility must be evaluated with regards to specific HLA alleles, genotypes, and haplotypes, and also ethnic and racial background.

Family-based association study of HLA class II with type 1 diabetes in Moroccans

2015 ◽  
Vol 63 (2) ◽  
pp. 80-84 ◽  
Author(s):  
A. Drissi Bourhanbour ◽  
N. Benseffaj ◽  
S. Ouadghiri ◽  
R. Razine ◽  
A. Touzani ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Family Based

scholarly journals Family-based analysis of tumor necrosis factor and lymphotoxin-α tag polymorphisms with type 1 diabetes in the population of South Croatia

2009 ◽  
Vol 70 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Vesna Boraska ◽  
Eleftheria Zeggini ◽  
Christopher J. Groves ◽  
Nigel W. Rayner ◽  
Veselin Škrabić ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Family Based ◽  
Lymphotoxin Α ◽  
Necrosis Factor

scholarly journals Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia

2007 ◽  
Vol 53 (3) ◽  
pp. 210-214 ◽  
Author(s):  
Vesna Boraska ◽  
Veselin Škrabić ◽  
Eleftheria Zeggini ◽  
Christopher James Groves ◽  
Maja Buljubašić ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
Family Based

scholarly journals Exploration of shared genetic susceptibility loci between type 1 diabetes and rheumatoid arthritis in the Pakistani population

2019 ◽  
Author(s):  
Muhammad Muaaz Aslam(Former Corresponding Author) ◽  
Peter John ◽  
Kang-Hsien Fan ◽  
Attya Bhatti ◽  
Sidrah Jahangir ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Control Sample ◽  
Case Control ◽  
Pakistani Population ◽  
Mixed Family ◽  
Small Set ◽  
Family Based

Abstract Objective Type 1 diabetes (T1D) and rheumatoid arthritis (RA) are autoimmune diseases. It is known that certain genetic loci and factors that increase the overall autoimmunity risk can be shared among different autoimmune diseases. We sought to replicate seven T1D-related SNPs that have been previously reported to be associated with RA susceptibility in a small set of mixed family-based and case-control Pakistani sample in a relatively large and independent RA case-control sample from the same population. Seven T1D-associted SNPs (GLIS3/rs7020673, BACH2/rs11755527, SKAP2/rs7804356, GDSMB/rs2290400, C6orf173/rs9388489, LOC399716/rs947474 and DLK1-MEG2/rs941576) were genotyped in a large Pakistani RA case-control sample (n=1,959) using TaqMan® SNP genotyping assays. Results None of the tested SNPs showed statistically significant association with RA susceptibility; however, one SNP (GLIS3/rs7020673) showed a trend for association (OR= 0.88, p=7.99E-02). Our study has failed to replicate the previously reported association of seven T1D-associted SNPs with RA risk in a large sample from the same population. Thus, our results do not support a major role of these T1D SNPs in affecting RA susceptibility in the Pakistani population.

scholarly journals Exploration of shared genetic susceptibility loci between type 1 diabetes and rheumatoid arthritis in the Pakistani population

2019 ◽  
Author(s):  
Muhammad Muaaz Aslam ◽  
Peter John ◽  
Kang-Hsien Fan ◽  
Attya Bhatti ◽  
Sidrah Jahangir ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Control Sample ◽  
Case Control ◽  
Pakistani Population ◽  
Mixed Family ◽  
Small Set ◽  
Family Based

Abstract Objective Type 1 diabetes (T1D) and rheumatoid arthritis (RA) are autoimmune diseases. It is known that certain genetic loci and factors that increase the overall autoimmunity risk can be shared among different autoimmune diseases. We sought to replicate seven T1D-related SNPs that have been previously reported to be associated with RA susceptibility in a small set of mixed family-based and case-control Pakistani sample in a relatively large and independent RA case-control sample from the same population. Seven T1D-associted SNPs (GLIS3/rs7020673, BACH2/rs11755527, SKAP2/rs7804356, GDSMB/rs2290400, C6orf173/rs9388489, LOC399716/rs947474 and DLK1-MEG2/rs941576) were genotyped in a large Pakistani RA case-control sample (n=1,959) using TaqMan® SNP genotyping assays. Results None of the tested SNPs showed statistically significant association with RA susceptibility; however, one SNP (GLIS3/rs7020673) showed a trend for association (OR= 0.88, p=7.99E-02). Our study has failed to replicate the previously reported association of seven T1D-associted SNPs with RA risk in a large sample from the same population. Thus, our results do not support a major role of these T1D SNPs in affecting RA susceptibility in the Pakistani population.

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