Excision of injection site substantially reduced serum insulin concentration in a potentially life-threatening insulin analogue overdose

2012 ◽  
Vol 29 (6) ◽  
pp. 243-245 ◽  
Author(s):  
J Droste ◽  
V Hundia ◽  
A Pettit ◽  
N Narayan ◽  
A Nejim
Keyword(s):  
Injection Site ◽  
Insulin Analogue ◽  
Serum Insulin ◽  
Insulin Concentration ◽  
Serum Insulin Concentration ◽  
Life Threatening

Age- and sex-related reference values for serum insulin concentration and its biological determinants in a French healthy population. The STANISLAS cohort

2004 ◽  
Vol 42 (10) ◽  
Author(s):  
Aurélie Francois ◽  
Sandy Maumus ◽  
Monique Vincent-Viry ◽  
René Guéguen ◽  
Gérard Siest ◽  
...  
Keyword(s):  
Contraceptive Use ◽  
Serum Insulin ◽  
Density Lipoprotein ◽  
Insulin Concentration ◽  
Healthy Population ◽  
Factors Affecting ◽  
Serum Insulin Concentration ◽  
Reference Limits ◽  
Adults And Children ◽  
Broad Variety

AbstractInsulin is involved in coronary heart disease through diabetes and metabolic syndrome. A great deal is known about insulin and its correlates, as well as factors related to changes in insulin. However, few studies consider the broad variety of correlates simultaneously. Therefore, the aims of the present study were to characterize the main factors of biological variation affecting serum insulin concentration and to establish reference limits of insulinemia in a presumably healthy French population. Insulin was measured using a microparticular enzymatic immunoassay. A total of 646 subjects aged 11–58 years from the STANISLAS cohort and divided into four groups of 162 males, 157 females, 163 boys and 164 girls, were included in the statistical analyses. In the whole population, serum insulin concentration varied from 0.80 to 54.60 µU/ml. Significant factors affecting insulin were age, gender, body mass index and glucose, in addition to alanine aminotransferase and high-density lipoprotein cholesterol in men, triglycerides and oral contraceptive use in women, and alkaline phosphatase in girls.In summary, we presented biological correlates of insulin in both healthy French male and female adults and children/adolescents and determined reference limits for insulin for each group. These results will contribute to a better interpretation of insulin data in further studies and laboratory investigations.

Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system

1986 ◽  
Vol 251 (6) ◽  
pp. E644-E647 ◽  
Author(s):  
L. Jansson ◽  
C. Hellerstrom
Keyword(s):  
Central Nervous System ◽  
Blood Flow ◽  
Nervous System ◽  
Glucose Concentration ◽  
Serum Insulin ◽  
Serum Glucose ◽  
Insulin Concentration ◽  
Similar Amount ◽  
Serum Insulin Concentration ◽  
Islet Blood Flow

Earlier experiments with the microsphere technique suggested that a heightened serum glucose concentration consistently leads to an increase in islet blood flow (IBF). Several lines of evidence suggest that this glucose-sensitive control mechanism is located at an extrapancreatic site. The purpose of this study was to define the possible role of the central nervous system in such a mechanism. D-glucose, L-glucose, 3-O-methylglucose, or saline were therefore infused into the carotid artery, each at a dose of 1 mg X kg body wt-1 X min-1 for 3 min, and the pancreatic and islet blood flows were measured. None of these substances affected the systemic serum glucose level. The intracarotid infusion of D-glucose, however, caused a rapid increase in both the serum insulin concentration and IBF. The blood flow to the whole pancreas nevertheless remained unchanged, indicating a redistribution of flow within the gland. Carotid infusion of the other test substances or a similar amount of D-glucose given in a femoral vein did not affect these parameters. Both the increase in serum insulin concentration and the increase in IBF caused by D-glucose could be abolished by vagotomy or administration of atropine. When the systemic blood glucose concentration was increased by intraperitoneal glucose administration (2 g/kg body wt), vagotomy blocked the increase in islet blood flow but not the concomitant insulin release. These observations suggest that the glucose-induced increase in IBF is mediated by vagal cholinergic influences.

Serum insulin concentration in horses: Effect of storage and handling

2016 ◽  
Vol 211 ◽  
pp. 94-96 ◽  
Author(s):  
Harry Carslake ◽  
Ninja Karikoski ◽  
Gina Pinchbeck ◽  
Catherine McGowan
Keyword(s):  
Serum Insulin ◽  
Insulin Concentration ◽  
Serum Insulin Concentration

SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES

The Lancet ◽  
1989 ◽  
Vol 333 (8651) ◽  
pp. 1356-1359 ◽  
Author(s):  
MohammedF. Saad ◽  
DavidJ. Pettitt ◽  
DavidM. Mott ◽  
WilliamC. Knowler ◽  
RobertG. Nelson ◽  
...  
Keyword(s):  
Serum Insulin ◽  
Insulin Dependent Diabetes ◽  
Insulin Concentration ◽  
Serum Insulin Concentration ◽  
Insulin Dependent

Chlorpropamide Poisoning

PEDIATRICS ◽  
1968 ◽  
Vol 41 (1) ◽  
pp. 145-147
Author(s):  
Barry Greenberg ◽  
Carl Weihl ◽  
George Hug
Keyword(s):  
Blood Sugar ◽  
Serum Insulin ◽  
Clinical Signs ◽  
Insulin Concentration ◽  
Serum Insulin Concentration ◽  
Normal Ranges

Clinical signs of hypoglycemia developed in a 3½-year-old boy 24 hours after he had eaten some of the attractively blue-colored chlorpropamide tablets. Low blood sugar values persisted for 4 days after the ingestion concomitant with an increase in serum insulin concentration. On the fifth day, the blood sugar rose to normal levels. The serum insulin concentration was not significantly out of the normal ranges on each of the four follow-up examinations.

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