Type II polyglandular autoimmune syndrome: an unusual presentation

2011 ◽  
Vol 28 (1) ◽  
pp. 41-42
Author(s):  
SM Phillips ◽  
MI Butt ◽  
AM Robinson
Keyword(s):  
Unusual Presentation ◽  
Type Ii ◽  
Polyglandular Autoimmune Syndrome ◽  
Autoimmune Syndrome

scholarly journals Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report

2018 ◽  
Vol 40 (07) ◽  
pp. 425-429
Author(s):  
Luiza Cottas ◽  
Maria Borges ◽  
Lívia Oliveira ◽  
Ana Resende ◽  
Meire Ataíde ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Primary Hypothyroidism ◽  
Primary Amenorrhea ◽  
Syndrome Type ◽  
Type Ii ◽  
Polyglandular Autoimmune Syndrome ◽  
Autoimmune Thyroid ◽  
Addison Disease ◽  
Autoimmune Syndrome ◽  
Polyglandular Autoimmune Syndrome Type

AbstractPolyglandular autoimmune syndrome type II (PGA-II) is a rare immunoendocrinopathy syndrome characterized by the occurrence of autoimmune Addison disease along with diabetes mellitus type 1 and/or autoimmune thyroid disease. Here, we report the case of a 23-year-old female with PGA-II who was followed up at the dermatology and endocrinology clinics of the Universidade Federal do Triângulo Mineiro, located in the state of Minas Gerais, Brazil. First, the patient presented diffuse skin hyperpigmentation, vitiligo; and in sequence, due to vomiting, appetite and weight loss, hypoglycemia, amenorrhea, and galactorrhea, the patient was then diagnosed with PGA-II. The patient also presented intense hyperprolactinemia due to primary hypothyroidism. The late diagnosis of PGA-II is frequent because the disorder is uncommon and has non-specific clinical manifestations. This report emphasizes the significance of a timely diagnosis and appropriate treatment to reduce morbidity and mortality associated with these diseases, especially Addison disease. The present study reports a rare case of a patient with PGA-II with primary amenorrhea associated with hyperprolactinemia.

scholarly journals Achalasia in a Patient with Polyglandular Autoimmune Syndrome Type II

2015 ◽  
Vol 9 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Bashar S. Amr ◽  
Chaitanya Mamillapalli
Keyword(s):  
Autoimmune Thyroid Disease ◽  
Syndrome Type ◽  
Type Ii ◽  
Rare Disorders ◽  
Polyglandular Autoimmune Syndrome ◽  
Autoimmune Thyroid ◽  
Autoimmune Syndrome ◽  
Esophageal Sphincter ◽  
Polyglandular Autoimmune Syndrome Type

Achalasia is a rare disease characterized by aperistalsis of the esophageal body and failure of the lower esophageal sphincter to relax. The etiology of this disease remains unknown. Polyglandular autoimmune syndrome type II is a well-identified disease characterized by the occurrence of autoimmune Addison's disease in combination with autoimmune thyroid disease and/or type 1 diabetes mellitus. We report a case that suggests autoimmunity and immunogenicity as a probable contributing factor for association of these two rare disorders.

Hypoadrenocorticism in a family of leonbergers

1995 ◽  
Vol 31 (4) ◽  
pp. 301-305 ◽  
Author(s):  
LJ Smallwood ◽  
JA Barsanti
Keyword(s):  
Thyroid Dysfunction ◽  
Type Ii ◽  
Polyglandular Autoimmune Syndrome ◽  
Serum Thyroxine ◽  
Human Type ◽  
Autoimmune Syndrome ◽  
Familial Association

Hypoadrenocorticism was diagnosed in four related leonbergers. Two of the four dogs also had low-resting serum thyroxine (T4) levels and signs consistent with hypothyroidism. The familial association of the affected dogs and the presence of coexisting thyroid dysfunction are similar to what is seen in human type II polyglandular autoimmune syndrome.

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