The ?in-plane? view of the inter-ventricular septum. A new approach to the characterization of ventricular septal defects in the fetus

2003 ◽  
Vol 23 (13) ◽  
pp. 1052-1055 ◽  
Author(s):  
Dario Paladini ◽  
Maria Giovanna Russo ◽  
Michele Vassallo ◽  
Antonio Tartaglione
Keyword(s):  
Ventricular Septum ◽  
Ventricular Septal Defects ◽  
New Approach ◽  
Septal Defects ◽  
Plane View

scholarly journals Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0131542 ◽  
Author(s):  
Fei-Feng Li ◽  
Jing Zhou ◽  
Dan-Dan Zhao ◽  
Peng Yan ◽  
Xia Li ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Gene Variants ◽  
Ventricular Septal Defects ◽  
Septal Defects

scholarly journals The Fate of the Outflow Tract Septal Complex in Relation to the Classification of Ventricular Septal Defects

2019 ◽  
Vol 6 (1) ◽  
pp. 9 ◽  
Author(s):  
Robert Anderson ◽  
Justin Tretter ◽  
Diane Spicer ◽  
Shumpei Mori
Keyword(s):  
Outflow Tract ◽  
Ventricular Septum ◽  
Ventricular Septal Defects ◽  
Atrioventricular Canal ◽  
Dorsal Wall ◽  
Septal Defects ◽  
Major Significance ◽  
Ongoing Development ◽  
The Right

It is now established that the entity often described as an “aortopulmonary septal complex” is better considered as an “outflow tract septal complex”. This change is crucial for appropriate understanding of not only malformations of the outflow tract, but also ventricular septal defects. Thus, the embryonic outflow tract, as it develops, is separated into its two components by fusion of a protrusion from the dorsal wall of the aortic sac with the distal end of the outflow cushions. The key point with regard to morphogenesis is that, with ongoing development, these structures lose their septal integrity, although they can still be identified as septal structures when the ventricular septum itself is deficient. In the normal postnatal heart, however, the aortic and pulmonary components have their own walls throughout the length of the outflow tracts. All of this is of clinical significance, since some current concepts of categorisation of the ventricular septal defects are based on the existence in the normal heart of a “conal septum”, along with a “septum of the atrioventricular canal”. In this review, we show how analysis of postnatal hearts reveals the definitive ventricular septum to possess only muscular and fibrous components in the absence of either discrete outflow or inlet components. We also show that this information regarding development, in turn, is of major significance in determining whether categorisation of ventricular septal defects is best approached, in the first instance, on the basis of the borders of the defects or the fashion in which they open to the right ventricle.

Usefulness of Live/Real Time Three-Dimensional Transthoracic Echocardiography in the Characterization of Ventricular Septal Defects in Adults

2006 ◽  
Vol 23 (5) ◽  
pp. 421-427 ◽  
Author(s):  
Farhat Mehmood ◽  
Andrew P. Miller ◽  
Navin C. Nanda ◽  
Vinod Patel ◽  
Anurag Singh ◽  
...  
Keyword(s):  
Real Time ◽  
Transthoracic Echocardiography ◽  
Three Dimensional ◽  
Ventricular Septal Defects ◽  
Septal Defects

scholarly journals Systematic Approach to Malalignment Type Ventricular Septal Defects

2020 ◽  
Vol 9 (22) ◽  
Author(s):  
Shi‐Joon Yoo ◽  
Mika Saito ◽  
Nabil Hussein ◽  
Fraser Golding ◽  
Hyun Woo Goo ◽  
...  
Keyword(s):  
Systematic Approach ◽  
Heart Diseases ◽  
Ventricular Septum ◽  
Reference Structure ◽  
Ventricular Septal Defects ◽  
Case Examples ◽  
Septal Defects ◽  
Pathological Conditions ◽  
Pictorial Essay ◽  
The Right

Abstract Various congenital heart diseases are associated with malalignment of a part of the ventricular septum. Most commonly, the outlet septum is malaligned toward the right or left ventricle. Less commonly, the whole or a major part of the ventricular septum is malaligned in relation to the atrial septal plane. Although the pathological conditions associated with ventricular septal malalignment have been well recognized, the descriptions are often confusing and sometimes incorrect. In this pictorial essay, we introduce our systematic approach to the assessment of malalignment type ventricular septal defects with typical case examples. The systematic approach comprises description of the essential features of malalignment, including the following: (1) the malaligned part of the ventricular septum, (2) the reference structure, (3) the mechanism of malalignment, (4) the direction of malalignment, and (5) the severity of malalignment.

scholarly journals Characterization of mesenchymal heart cells obtained from patients with tetralogy of Fallot and ventricular septal defect

2019 ◽  
Vol 6 (5) ◽  
pp. 16-23
Author(s):  
I. A. Kozyrev ◽  
A. S. Golovkin ◽  
E. S. Ignatieva ◽  
P. M. Dokshin ◽  
E. V. Grekhov ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Tetralogy Of Fallot ◽  
Septal Defect ◽  
Mesenchymal Cells ◽  
Stem Cell Marker ◽  
Heart Cells ◽  
Ventricular Septal Defects ◽  
Phenotypic Analysis ◽  
Septal Defects

Objective. Phenotypic analysis of cardiac mesenchymal cells from patients with a ventricular septal defect and tetralogy of Fallot.Methods. The study included cardiac mesenchymal cells from 8 patients with ventricular septal defect and from 18 patients with tetralogy of Fallot who underwent surgery. Using the flow cytometry method, the content of the following antigens on the cell surface was evaluated: CD31, CD34, CD90, CD117, CD146, CD166, PDGFRB.Results. Cardiac mesenchymal cells from patients with ventricular septal defect are statistically significantly different from patients with tetralogy of Fallot in surface markers CD90 and PDGFRB. The content of a stem cell marker PDGFRB tends to decrease with age in patients with tetralogy of Fallot.Conclusion. The cells obtained from myocardial tissue from patients with tetralogy of Fallot and from patients with ventricular septal defects have characteristics of mesenchymal stem cells. The differences found between the cells from the two groups of patients indicate that pathology can affect the phenotype of cardiac mesenchymal cells. Apparently, the stem properties of the mesenchymal heart cells tend to decrease with age.

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