scholarly journals Neurodevelopmental outcomes in children with isolated congenital diaphragmatic hernia: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Lennart Van der Veeken ◽  
Simen Vergote ◽  
Yada Kunpalin ◽  
Karl Kristensen ◽  
Jan Deprest ◽  
...  
Keyword(s):  
Systematic Review ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Meta Analysis ◽  
Neurodevelopmental Outcomes

Surgical approaches for neonatal congenital diaphragmatic hernia: a systematic review and meta-analysis

2015 ◽  
Vol 31 (10) ◽  
pp. 891-897 ◽  
Author(s):  
Keita Terui ◽  
Kouji Nagata ◽  
Miharu Ito ◽  
Masaya Yamoto ◽  
Masayuki Shiraishi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Meta Analysis ◽  
Surgical Approaches

scholarly journals Ventricular Function in Congenital Diaphragmatic Hernia: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Rameshwar Prasad ◽  
Bijan Saha ◽  
Amit Kumar
Keyword(s):  
Systematic Review ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Congenital Diaphragmatic Hernia ◽  
Ventricular Function ◽  
Sensitivity And Specificity ◽  
Diaphragmatic Hernia ◽  
Ventricular Dysfunction ◽  
Meta Analysis ◽  
Left Ventricular

Abstract There is emerging evidence supporting ventricular function as a prognostic factor in congenital diaphragmatic hernia (CDH). The present systematic review and meta-analysis aimed to determine the predictive value of early ventricular function for survival and extracorporeal membrane oxygenation (ECMO) requirement in newborns with CDH. PubMed, Google Scholar, Cochrane Central Register, Clinical Trial Registry, and Opengrey were accessed. Studies evaluating associations between echocardiographic ventricular function measured ≤ 48 h after birth and survival or ECMO requirement were included. Two independent authors extracted the following data: study and participant characteristics, prognostic factors, and outcome-related data. Eleven studies met the inclusion criteria. Five studies reported on survival, two on ECMO, and four on both outcomes. A moderate risk of bias was found in most of the studies, mainly because of selection, prognostic factors, and confounding biases. For survival (899 participants), pooled sensitivity and specificity were 86% (95% confidence interval [CI], 77–92%) and 44% (95% CI, 25–65%), respectively, in normal left ventricular function. For ECMO need (815 participants), pooled sensitivity and specificity were 39.8% (95% CI, 27–52%) and 88% (95% CI, 80–96%), respectively, in left ventricular dysfunction. Overall certainty of the evidence was graded very low for survival and low for ECMO. Inconsistent reporting of echocardiographic measurements and lack of adjustment for confounding factors were major limitations. Conclusions: Early ventricular dysfunction is a potential prognostic factor in CDH. Standardized echocardiographic measurement reporting and high-quality studies are needed to further elucidate its prognostic significance.

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