Fetal acute cerebral vasoreactivity to maternal hyperoxia in low‐risk pregnancies: a cross‐sectional study

2020 ◽  
Vol 40 (7) ◽  
pp. 813-824
Author(s):  
Laura Sanapo ◽  
Tareq Al‐Shargabi ◽  
Homa K. Ahmadzia ◽  
David N. Schidlow ◽  
Mary T. Donofrio ◽  
...  
2010 ◽  
Vol 95 (Supplement 1) ◽  
pp. Fa39-Fa39
Author(s):  
N. Murphy ◽  
B. Wallace ◽  
D. Broadhurst ◽  
A. Khashan ◽  
O. Gilligan ◽  
...  

2020 ◽  
Author(s):  
L Savic ◽  
C Thomas ◽  
D Fallaha ◽  
Michelle Wilson ◽  
PM Hopkins ◽  
...  

AbstractBackgroundDirect drug provocation testing (DPT) in patients with low-risk penicillin allergy labels would allow population-level ‘de-labelling’. We sought to determine the incidence and nature of penicillin allergy labels in a large UK surgical cohort and to define patient and anaesthetist attitudes towards penicillin allergy testing.MethodsA prospective cross-sectional study was performed in 213 UK hospitals. ‘Penicillin allergic’ patients were interviewed and risk-stratified. Knowledge and attitudes around penicillin allergy were defined in patients and anaesthetists, determining potential barriers to widespread testing.FindingsOf 21,281 patients 12% self-reported penicillin allergy and 67% of these were potentially suitable for direct DPT (stratified low or intermediate risk). Irrespective of risk category 62% wanted allergy testing. Of 4,978 anaesthetists 40% claimed to routinely administer penicillin when they judge the label to be low-risk; 64% would then tell the patient they had received penicillin. Only 47% of all anaesthetists would be happy to administer penicillin to a patient previously de-labelled by an allergy specialist using direct DPT; the commonest reason not to administer penicillin was perceived lack of support from their hospital. On the study days, 13% of low-risk patients requiring penicillin received it, and 6 patients with high-risk labels received it. There were no adverse events in any of this group. However, 1 patient who received an alternative antibiotic suffered suspected anaphylaxis to this.InterpretationThe majority of patients with a penicillin allergy label may be suitable for direct DPT and demand for testing is high among patients. Anaesthetists demonstrate inconsistent, potentially unsafe prescribing in patients labelled as penicillin allergic. More than half of anaesthetists are not reassured by a negative DPT undertaken by a specialist. Significant knowledge gaps may prevent widespread de-labelling being effectively implemented in surgical patients.FundingThe National Institute of Academic Anaesthesia.


2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110583
Author(s):  
Lawless Robert ◽  
Vickers Mark ◽  
Alawami Moayed ◽  
Appasamy Nivashen ◽  
Rajasingam Vinod ◽  
...  

Objective We aimed to assess prescribing practices, compliance with guidelines, and outcomes for patients who were admitted to the authors’ institution with community-acquired pneumonia (CAP). Methods We performed a single-center retrospective cross-sectional study of adults with CAP presenting during the 2019 influenza season. CAP severity was assessed using the CURB-65 risk score. The effect of CURB-65 risk score use on the rate of appropriate antimicrobial prescribing was assessed using the chi-square test and reported as odds ratio (OR). Fisher’s exact test was used to assess the relationship between prescribing appropriateness and patient outcomes. Results Patients with low-risk CAP were most likely to be inappropriately prescribed antimicrobials (OR: 4.77; 95% confidence interval: 2.44–10.47). In low-risk CAP, the most common prescribing error was overuse of ceftriaxone. In high-risk CAP, the most common errors were ceftriaxone underdosing and missed atypical coverage with azithromycin. Overall, 80% of patients were considered to have been inappropriately prescribed antimicrobials. No effect on mortality was observed. Conclusions In this study, we found low use of CAP risk scores and low adherence to antimicrobial prescribing guidelines for CAP at the authors’ institution.


2020 ◽  
Vol 36 ◽  
Author(s):  
Ola Ahmed Abdulmjeed Mohammed ◽  
Fatima abdulraheem Ahmed ◽  
Abubaker Imad Eldeen Adlan Koko ◽  
Sufian Elshafee Osman Khalifa ◽  
Hind Abdelaziz Mohamed Abdelaziz ◽  
...  

2021 ◽  
Vol 16 (4) ◽  
Author(s):  
Fajar Ariyanti ◽  
Mustakim Mustakim ◽  
Moch Thoriq Assegaf Al Ayubi ◽  
Desty Pratiwi Marlisman

In Indonesia at the end of 2020, COVID-19 cases were increasing and predicted to continue, as Indonesia had not yet passed the peak of the pandemic curve. The government had implemented mobility restrictions to reduce exposure to COVID-19. However, there is still a lack of studies in Indonesia that have assessed the risks of COVID-19 transmission based on people’s daily activities. This study aimed to identify the risk of people getting COVID-19 based on their daily activities. This study used a cross-sectional study design. It took 315 respondents under non probability sampling from September to October 2020. The data were analyzed using thechi-square test with α 0.05. This study showed that the risk percentage of people being infected with COVID-19 based on their daily activities was 15.56% at low risk, 63.81% at moderate-low risk, 17.14% at moderate risk, and 3.9% at moderate-high risk. Factors that were significantly related to the risk of getting COVID-19 in terms of daily activities were biological sex, attitude, and COVID-19 preventive behavior. The conclusion of this study was that the assessment of the risk of getting COVID-19 could be derived from daily activities carried out during the peak of the pandemic.


2017 ◽  
Vol 20 (6) ◽  
pp. 805-813 ◽  
Author(s):  
Luisa Veríssimo Pereira Sampaio ◽  
Leonardo Braga Castilho ◽  
Gustavo de Azevedo Carvalho

Abstract Objective: to develop an application for mobile devices to evaluate the balance and risk of falls of the elderly. Method: A cross-sectional study with a sample composed of 54 elderly individuals with an average age of 71 years submitted to three balance and risk of falls evaluation tests, was performed. The Timed Up and Go (TUG) and Performance Oriented Mobility Assessment (POMA) tests were employed. Results: The results were closely correlated, identifying three groups of volunteers: low, medium and high risk of falls. When these values were compared with the analyzes performed by the application, some of the variations in the results generated by the application were not related to the classic tests, as the software could discriminate between individuals with a high and low risk of falls. Conclusion: The developed application was able to verify the oscillations present in the maintenance of static balance of the elderly and could differentiate the results into two groups of high and low risk of falls.


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