Noninvasive assessment of fetal central nervous system insult: Potential application to prenatal diagnosis

2019 ◽  
Vol 39 (8) ◽  
pp. 609-615 ◽  
Author(s):  
Laura Goetzl ◽  
Nune Darbinian ◽  
Nana Merabova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Potential Application ◽  
Noninvasive Assessment

Virtual ultrasound embryo autopsy – myth or reality? Part 1

2017 ◽  
Author(s):  
A.Yu. Blinov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Medical Imaging ◽  
Embryonic Development ◽  
Human Embryos ◽  
Review Of Literature ◽  
Embryonic Period ◽  
New Methods ◽  
Central Nervous System Defects

A review of literature data on the study of human embryos using new methods of medical imaging is given. The possibility of prenatal diagnosis of severe central nervous system defects has been demonstrated already in the embryonic period at 8–10 weeks of gestation or at the age of 16 to 23 stages of the embryonic development period

Clinical study of fetal neurobehavior by the KANET test

2018 ◽  
Vol 46 (6) ◽  
pp. 631-639
Author(s):  
Raul Moreira Neto ◽  
Selma Porovic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Behavior Pattern ◽  
Review Of Literature ◽  
Fetal Medicine ◽  
Morphological Studies ◽  
4D Ultrasound ◽  
Spontaneous Movements

AbstractFetal neurology is evolving as an area of great interest in prenatal diagnosis and fetal medicine. The identification and diagnosis of brain damage prenatally has been a great challenge in obstetrics for many years. Investigations of fetal behavior in comparison with morphological studies led to the conclusion that fetal behavioral patterns directly reflect developmental and maturational processes of the fetal central nervous system (CNS). Four-dimensional (4D) ultrasound has greatly improved the assessment of the quality of the fetal spontaneous movements, and enabled a better evaluation of fetal behavior. The assessment of normal neurobehavioral development by 4D ultrasound provided the opportunity to investigate functional characteristics of the fetus that could predict neurological developmental dysfunction. Some studies have already been carried out to evaluate this new methodology in the observation of fetal behavior during different stages of gestation, in an attempt to better understand the relationships between the maturation of the CNS of the fetus and its implications on its behavior pattern. We present a review of literature on fetal behavior by 4D ultrasound.

Collaborative Study on 3-Dimensional Sonography for the Prenatal Diagnosis of Central Nervous System Defects

2011 ◽  
Vol 30 (7) ◽  
pp. 1003-1008 ◽  
Author(s):  
Giuseppe Rizzo ◽  
Alfred Z. Abuhamad ◽  
Beryl R. Benacerraf ◽  
Rabih Chaoui ◽  
Edgardo Corral ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Collaborative Study ◽  
3 Dimensional ◽  
Central Nervous System Defects

Our clinical experience about prenatal diagnosis and neonatal outcomes of fetal central nervous system anomalies

2010 ◽  
Vol 24 (3) ◽  
pp. 502-505 ◽  
Author(s):  
Zehra Sema Özkan ◽  
Hasan Çilgin ◽  
Hatice Banu Aygün ◽  
Derya Devecı ◽  
Mehmet Şımşek ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Clinical Experience ◽  
Neonatal Outcomes ◽  
Central Nervous System Anomalies

scholarly journals Fetal Central Nervous System and Infectious Diseases

2017 ◽  
Vol 11 (4) ◽  
pp. 314-327
Author(s):  
Lucia Masini ◽  
Massimo Apicella ◽  
Carmen De Luca ◽  
Piero Valentini ◽  
Riccardo Manfredi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Infectious Diseases ◽  
Congenital Infection ◽  
Global Scale ◽  
Complete Evaluation ◽  
Predictive Values ◽  
Congenital Infections ◽  
Magnetic Resonance Imaging Mri

ABSTRACT Maternal infectious diseases are frequent complications of pregnancy and can cause negative outcomes. Perinatal infections can cause serious damage to fetal central nervous system (CNS), but incidence of symptomatic congenital infections at birth is low. Complete and multidisciplinary (obstetric, infectologist, microbiologist, neonatologist/pediatrician, psychologist) evaluation of the pregnant women is crucial to define fetal prognosis. The ultrasound (US) surveillance has an irreplaceable role in identifying serious fetal damage and complications. Complete evaluation of the fetus in selected cases needs to be integrated with invasive prenatal diagnosis, particularly amniocentesis, which has optimal predictive values in excluding vertical transmission, and fetal magnetic resonance imaging (MRI), which can add important anatomical detail when fetal CNS damage is suspected. Congenital infections, furthermore, need to be considered in differential diagnosis of some common abnormal CNS findings at prenatal US. With the present review, we intend to provide an overview of the major perinatal infections and the role of US diagnosis in their assessment to recognize fetal CNS damage. We highlight the most recognizable syndromes due to congenital infections by linking etiopathogenesis with pathology and imaging. In particular, we focus on US diagnostic and prognostic values in relation to other invasive and noninvasive prenatal diagnosis options and summarize up-to-date recommendations on US evaluation of most common findings. Cytomegalovirus (CMV) is the most common cause of congenital infection, while Toxoplasmosis is the most preventable cause of infectious CNS damage; rubella, varicella virus, and herpes viruses, even if rarely, may be responsible for extremely serious fetal damage, while Zika virus is an emerging concern on global scale. How to cite this article Masini L, Apicella M, De Luca C, Valentini P, Manfredi R, Lanzone A, De Santis M. Fetal Central Nervous System and Infectious Diseases. Donald School J Ultrasound Obstet Gynecol 2017;11(4):314-327.

scholarly journals Real-Life Diagnostic Accuracy of MRI in Prenatal Diagnosis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Manuel Recio Rodríguez ◽  
Cristina Andreu-Vázquez ◽  
Israel J. Thuissard-Vasallo ◽  
Raquel Cano Alonso ◽  
Carmina Bermejo López ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Diagnostic Accuracy ◽  
Fetal Mri ◽  
Accurate Diagnosis ◽  
Fetal Ultrasound ◽  
Additional Information ◽  
Perinatal Management ◽  
Cns Pathology

There is some controversy about the value of fetal MRI in prenatal diagnosis, and most of the studies examine its accuracy in central nervous system (CNS) pathology. The objective of this retrospective study was to assess the diagnostic accuracy and usefulness of fetal MRI in the prenatal diagnosis of central nervous system (CNS) pathology and non-CNS pathology. Patients referred to the Radiology Department between 2007 and 2018 for a fetal MRI after detection of an anomaly in the fetal ultrasound, a high-risk pregnancy, or an inconclusive fetal ultrasound (n = 623) were included in the study. Postnatal diagnosis was used to assess the diagnostic accuracy of MRI. Fetal MRI was considered to provide additional information over fetal ultrasound when findings of the fetal MRI were not detected in the fetal ultrasound or when established a pathological condition that was not detected in the fetal ultrasound. Fetal MRI provided useful information for the perinatal management and prognosis over fetal ultrasound when findings of the fetal MRI changed the postnatal prognosis, leaded to the decision to legally terminate the pregnancy, changed prenatal or postnatal follow-up, or helped in the planning of prenatal or postnatal treatment. Fetal MRI offered an accurate diagnosis in 97% of cases (compared to 90.4% of fetal ultrasound; p < 0.001 ). Concordance between fetal ultrasound and fetal MRI was 92.1%. Fetal MRI provided additional information over fetal ultrasound in 23.1% of cases. In 11.6% of cases, the information was useful for the perinatal management and prognosis. In 45 cases (7.2%), fetal MRI was the only accurate diagnosis. In conclusion, fetal MRI has a superior diagnostic accuracy, especially in CNS pathology, and provides additional useful information in CNS, thoracic, and abdominal pathology.

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