Performance of non-invasive prenatal screening for fetal aneuploidy in twin pregnancies: a meta-analysis

2017 ◽  
Vol 37 (9) ◽  
pp. 874-882 ◽  
Author(s):  
Hong Liao ◽  
Shanling Liu ◽  
He Wang
Keyword(s):  
Prenatal Screening ◽  
Meta Analysis ◽  
Non Invasive ◽  
Fetal Aneuploidy ◽  
Twin Pregnancies

scholarly journals Routinization of prenatal screening with the non-invasive prenatal test: pregnant women’s perspectives

2021 ◽  
Author(s):  
Karuna R. M. van der Meij ◽  
Annabel Njio ◽  
Linda Martin ◽  
Janneke T. Gitsels-van der Wal ◽  
Mireille N. Bekker ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Prenatal Screening ◽  
Screening Program ◽  
Informed Choice ◽  
Aneuploidy Screening ◽  
Non Invasive ◽  
Fetal Aneuploidy ◽  
Societal Pressure ◽  
Prenatal Test

AbstractDue to the favorable test characteristics of the non-invasive prenatal test (NIPT) in the screening of fetal aneuploidy, there has been a strong and growing demand for implementation. In the Netherlands, NIPT is offered within a governmentally supported screening program as a first-tier screening test for all pregnant women (TRIDENT-2 study). However, concerns have been raised that the test’s favorable characteristics might lead to uncritical use, also referred to as routinization. This study addresses women’s perspectives on prenatal screening with NIPT by evaluating three aspects related to routinization: informed choice, freedom to choose and (personal and societal) perspectives on Down syndrome. Nationwide, a questionnaire was completed by 751 pregnant women after receiving counseling for prenatal screening. Of the respondents, the majority (75.5%) made an informed choice for prenatal screening as measured by the multidimensional measure of informed choice (MMIC). Education level and religious affiliation were significant predictors of informed choice. The main reason to accept screening was “seeking reassurance” (25.5%), and the main reason to decline was “every child is welcome” (30.6%). The majority of respondents (87.7%) did not perceive societal pressure to test. Differences between test-acceptors and test-decliners in personal and societal perspectives on Down syndrome were found. Our study revealed high rates of informed decision-making and perceived freedom to choose regarding fetal aneuploidy screening, suggesting that there is little reason for concern about routinization of NIPT based on the perspectives of Dutch pregnant women. Our findings highlight the importance of responsible implementation of NIPT within a national screening program.

Non-invasive Prenatal Screening for Fetal Aneuploidy: Comparison with Cytogenetic Results

2015 ◽  
Vol 3 (3) ◽  
pp. 127-136
Author(s):  
Jeanne M. Meck ◽  
Girish V. Putcha ◽  
Athena M. Cherry
Keyword(s):  
Prenatal Screening ◽  
Non Invasive ◽  
Fetal Aneuploidy

scholarly journals Clinical Efficiency of Non-invasive Prenatal Screening for Common Trisomies in Low-Risk and Twin Pregnancies

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanfei Xu ◽  
Pengzhen Jin ◽  
Yu Lei ◽  
Yeqing Qian ◽  
Yuqing Xu ◽  
...  
Keyword(s):  
High Risk ◽  
Predictive Value ◽  
Prenatal Screening ◽  
Low Risk ◽  
Trisomy 13 ◽  
Non Invasive ◽  
Clinical Efficiency ◽  
Sensitivity Specificity ◽  
Twin Pregnancies ◽  
Singleton Pregnancies

To evaluate the clinical efficiency of non-invasive prenatal screening (NIPS) for fetal aneuploidies in low-risk and twin pregnancies, patients who received NIPS in a tertiary university hospital were enrolled, and their clinical data, NIPS results and pregnancy outcomes were collected. Patients were divided into singleton and twin pregnancies, and then those with singleton pregnancies were divided into low- and high-risk pregnancies. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Comparisons were made on the clinical efficiency of NIPS between singleton and twin pregnancies, as well as between low- and high-risk pregnancies. Of 66,172 patients enrolled, 59,962 were eligible for analysis. The sensitivity, specificity and NPV were ≥ 99% in singleton and twin pregnancies. The PPVs were 90.4, 56.6, and 13.0% in singleton pregnancies, while 100, 33.3, and 0% in twin pregnancies for trisomy 21 (T21), trisomy 18 (T18) and trisomy 13 (T13), respectively (P > 0.05 for all). The PPVs were 97.4 and 90.0% in high-risk pregnancies, while 78.6 and 16.7% in low-risk pregnancies for T21 and T18, respectively (P < 0.05 for all). In summary, the performance of NIPS in singleton pregnancies was similar to that in twin pregnancies. NIPS can be recommended for all pregnancies regardless of the risks.

Non-invasive prenatal screening of fetal Down syndrome by maternal plasma DNA sequencing in twin pregnancies

2012 ◽  
Vol 26 (4) ◽  
pp. 434-437 ◽  
Author(s):  
Tze Kin Lau ◽  
Fuman Jiang ◽  
Mei Ki Chan ◽  
Hongyun Zhang ◽  
Pui Shan Salome Lo ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Dna Sequencing ◽  
Prenatal Screening ◽  
Maternal Plasma ◽  
Plasma Dna ◽  
Non Invasive ◽  
Twin Pregnancies
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