Molecular weight forms of inhibin A, inhibin B and pro-αC in maternal serum, amniotic fluid and placental extracts of normal and Down syndrome pregnancies

2002 ◽  
Vol 22 (12) ◽  
pp. 1086-1092 ◽  
Author(s):  
P. P. Thirunavukarasu ◽  
G. Lambert-Messerlian ◽  
D. M. Robertson ◽  
G. Dawson ◽  
J. Canick ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Down Syndrome ◽  
Amniotic Fluid ◽  
Maternal Serum ◽  
Inhibin B ◽  
Inhibin A

Placental, Maternal Serum and Amniotic Fluid Molecular Weight Forms of Inhibin A and Pro-αC

Placenta ◽  
2003 ◽  
Vol 24 (4) ◽  
pp. 370-377 ◽  
Author(s):  
P Thirunavukarasu ◽  
D.M Robertson ◽  
A Dole ◽  
K Waldron ◽  
G Dawson ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Amniotic Fluid ◽  
Maternal Serum ◽  
Inhibin A

Maternal serum and amniotic fluid levels of macrophage inhibitory cytokine 1 in Down syndrome and chromosomally normal pregnancies

2004 ◽  
Vol 24 (3) ◽  
pp. 224-226 ◽  
Author(s):  
Euan M. Wallace ◽  
Budi Marjono ◽  
David A. Brown ◽  
Jennifer Crossley ◽  
Stephen Tong ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amniotic Fluid ◽  
Maternal Serum ◽  
Fluid Levels

scholarly journals A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy

1998 ◽  
Vol 13 (12) ◽  
pp. 3530-3536 ◽  
Author(s):  
P. A. Fowler ◽  
L. W. Evans ◽  
N. P. Groome ◽  
A. Templeton ◽  
P. G. Knight
Keyword(s):  
Longitudinal Study ◽  
Activin A ◽  
Maternal Serum ◽  
Inhibin B ◽  
Inhibin A

scholarly journals Maternal Serum and Amniotic Fluid Inhibin A Levels in Women who Subsequently Develop Severe Preeclampsia

2006 ◽  
Vol 21 (3) ◽  
pp. 452 ◽  
Author(s):  
Shin-Young Kim ◽  
Hyun-Mee Ryu ◽  
Jae-Hyug Yang ◽  
Moon-Young Kim ◽  
Hyun-Kyong Ahn ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Inhibin A

Evaluation of a Dimeric Inhibin-A Assay for Assessing Fetal Down Syndrome: Establishment, Comparison, and Monitoring of Median Concentrations for Normal Pregnancies

2004 ◽  
Vol 128 (4) ◽  
pp. 415-420
Author(s):  
J. Alan Erickson ◽  
Edward R. Ashwood ◽  
Cynthia A. Gin
Keyword(s):  
Down Syndrome ◽  
Gestational Age ◽  
Maternal Serum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Systems ◽  
Maternal Serum Screening ◽  
Inhibin A ◽  
Screening Programs ◽  
Polynomial Fit ◽  
Subsequent Decrease

Abstract Context.—Several studies report the role of dimeric inhibin-A in assessing risk for fetal Down syndrome. The majority, however, use the Serotec inhibin-A assay and not the newer Diagnostic Systems Laboratories inhibin-A enzyme-linked immunosorbent assay (ELISA). Objectives.—To establish normal gestational age day-specific medians, to compare our results against previous studies pertaining to the inhibin-A ELISA, and to evaluate long-term assay performance. Design.—Using the inhibin-A ELISA, 100 specimens were assayed for each completed week of gestation for weeks 15 to 20, 50 specimens for 14 weeks, and 54 specimens for 21 weeks or older. Regressed inhibin-A medians were calculated employing a second-degree polynomial fit of the arithmetic medians. Thereafter, inhibin-A ELISA lot comparisons were performed to evaluate consistency. Results.—Regressed values of 182, 174, 175, 184, 201, and 226 pg/mL resulted for weeks 15 to 20, respectively [pg/mL inhibin-A = 4.1528(gestational age)2 − 136.49(gestational age) + 1294.9]. A comparison with 2 other studies shows our values to be lower overall by 15 ± 11.4% and 16 ± 2.6%. However, variability between kit lots was as high as 30%. Conclusions.—The equation derived provides for the calculation of gestational age day-specific inhibin-A medians for integration into maternal serum screening programs with a subsequent decrease in false-positives expected and observed. Our medians differ considerably from those of other studies, with limited data, using the Diagnostic Systems assay. However, lot changes since the initial analysis have exhibited similar inconsistencies. Therefore, we recommend that others incorporating the assay into their screening programs carefully establish, monitor, and adjust their medians accordingly as a result of potential variations.

scholarly journals Molecular Weight Forms of Inhibin A and Inhibin B in the Bovine Testis Change with Age1

2003 ◽  
Vol 68 (5) ◽  
pp. 1918-1925 ◽  
Author(s):  
H. Kaneko ◽  
J. Noguchi ◽  
K. Kikuchi ◽  
Y. Hasegawa
Keyword(s):  
Molecular Weight ◽  
Inhibin B ◽  
Inhibin A

scholarly journals Second trimester levels of maternal serum total activin A and placental inhibin/activin alpha and betaA subunit messenger ribonucleic acids in Down syndrome pregnancy

1998 ◽  
pp. 425-429 ◽  
Author(s):  
GM Lambert-Messerlian ◽  
S Luisi ◽  
P Florio ◽  
V Mazza ◽  
JA Canick ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Placental Tissue ◽  
Normal Karyotype ◽  
Activin A ◽  
Maternal Serum ◽  
Mrna Levels ◽  
Serum Samples ◽  
Inhibin A ◽  
Ribonucleic Acids ◽  
Gapdh Mrna

OBJECTIVES: Previous data have shown that inhibin A (alpha/betaA) is increased about twofold in maternal serum samples from Down syndrome pregnancy. Our objectives were to determine whether activin A (betaA/betaA) was similarly increased in maternal serum from pregnancies affected with fetal Down syndrome, and to investigate whether increased expression of each inhibin/activin subunit occurred in placental tissue from cases of fetal Down syndrome. DESIGN AND METHODS: Maternal serum total activin A levels were measured in 20 cases of fetal Down syndrome and 100 unaffected pregnancy samples. In addition, analysis of inhibin/activin alpha and betaA subunit mRNA levels was performed in placental tissue extracts from six cases of fetal Down syndrome and six tissues with a normal karyotype. RESULTS: The median total activin A level in the Down syndrome cases was 0.82 MoM (multiples of the median); values did not differ significantly (P = 0.36, Mann-Whitney U analysis) from those in unaffected pregnancies. The inhibin alpha subunit/GAPDH mRNA ratio, but not that of betaA subunit/GAPDH mRNA, was significantly greater (P < 0.01, ANOVA) in placental tissue from Down syndrome than in control placental tissue. CONCLUSIONS: Unlike inhibin A, activin A is not significantly increased in Down syndrome relative to unaffected pregnancy. Furthermore, increased amounts of maternal serum inhibin A in Down syndrome pregnancy probably result from increased placental expression of inhibin alpha, but not betaA, subunit.

Maternal serum α-fetoprotein and dimeric inhibin A detect aneuploidies other than Down syndrome

1998 ◽  
Vol 179 (4) ◽  
pp. 966-970 ◽  
Author(s):  
Katharine D. Wenstrom ◽  
D.C. Chu ◽  
John Owen ◽  
Larry Boots
Keyword(s):  
Down Syndrome ◽  
Maternal Serum ◽  
Inhibin A
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