Prenatal diagnosis of intra-abdominal cystic lesions by fetal ultrasonography: diagnostic agreement between prenatal and postnatal diagnosis

2015 ◽  
Vol 35 (9) ◽  
pp. 848-852 ◽  
Author(s):  
Giulia Marchitelli ◽  
Julien Stirnemann ◽  
Marta Maddalena Acanfora ◽  
Veronique Rousseau ◽  
Laurent J. Salomon ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Cystic Lesions ◽  
Diagnostic Agreement ◽  
Fetal Ultrasonography ◽  
Postnatal Diagnosis

OP28.07: Prenatal diagnosis of intra-abdominal cystic lesions: accuracy of fetal ultrasonography

2014 ◽  
Vol 44 (S1) ◽  
pp. 131-131
Author(s):  
G. Marchitelli ◽  
J. Stirnemann ◽  
V. Rousseau ◽  
M. Acanfora ◽  
L.J. Salomon ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Cystic Lesions ◽  
Fetal Ultrasonography

Magnetic resonance imaging versus ultrasonography for the in utero evaluation of central nervous system anomalies

2010 ◽  
Vol 6 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Pierpaolo Peruzzi ◽  
Rebecca J. Corbitt ◽  
Corey Raffel
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prenatal Diagnosis ◽  
Mr Imaging ◽  
False Negative ◽  
In Utero ◽  
Resonance Imaging ◽  
Fetal Ultrasonography ◽  
Negative Results ◽  
False Negative Results ◽  
Fetal Mr

Object The use of fetal MR imaging for the in utero evaluation of pathological conditions of the CNS is widely accepted as an adjunct to fetal ultrasonography studies. Magnetic resonance imaging is thought to characterize CNS anomalies better, and to provide a more exact diagnosis and accurate prognosis. The purpose of this study was to determine the role of and indications for fetal MR imaging in evaluating fetuses with different CNS abnormalities that were seen initially on prenatal sonograms. Methods Over a 3-year period, fetuses with prior sonographic evidence of CNS abnormalities who consequently received prenatal MR imaging at Columbus Nationwide Children's Hospital within 2 weeks of the fetal ultrasonography study were included in this study. For each patient, radiological reports from both studies were reviewed, analyzed, and compared with the findings at postnatal imaging or physical examination. Results of the 2 modalities were then compared in terms of diagnostic accuracy. Results Twenty-six fetuses were included in this study on the basis of an in utero sonogram showing a CNS anomaly. Their gestational age ranged from 17 to 35 weeks, with a mean of 25 weeks at the time of fetal ultrasonography. Hydrocephalus was identified in 16 fetuses, 6 had evidence of a spinal dysraphic defect, 2 had holoprosencephaly, 1 had an encephalocele, and 1 had multiple body abnormalities requiring detailed CNS evaluation. Twenty-five of the fetuses were correctly evaluated as having abnormal CNS findings on both fetal ultrasonography and fetal MR imaging. Fetal ultrasonography provided a correct prenatal diagnosis in 20 cases, whereas fetal MR imaging was correct in 22 cases. There were 9 cumulative false-positive results for fetal ultrasonography and 7 for fetal MR imaging, whereas for false-negative results there were a total of 34 and 19, respectively. Conclusions Fetal MR imaging is more sensitive in detecting fetal CNS abnormalities, but its ability to provide a correct prenatal diagnosis is only marginally superior to fetal ultrasonography. Moreover, fetal MR imaging is not exempt from misdiagnosis, and still shows a significantly high rate of false-negative results. Particularly for spinal dysraphic defects, fetal MR imaging does not seem to add important diagnostic or prognostic details when compared with fetal ultrasonography.

scholarly journals Parental reactions, distress, and sense of coherence after prenatal versus postnatal diagnosis of complex congenital heart disease

2019 ◽  
Vol 29 (11) ◽  
pp. 1328-1334 ◽  
Author(s):  
Ewa-Lena Bratt ◽  
Stina Järvholm ◽  
Britt-Marie Ekman-Joelsson ◽  
Antje Johannsmeyer ◽  
Sven-Åke Carlsson ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Life Satisfaction ◽  
Heart Disease ◽  
Prenatal Diagnosis ◽  
Pregnant Women ◽  
Sense Of Coherence ◽  
Congenital Heart ◽  
Depression Scale ◽  
Complex Congenital Heart Disease ◽  
Postnatal Diagnosis

AbstractIntroduction:A diagnosis of congenital heart disease (CHD) in offspring triggers psychological distress in parents. Results of previous studies have been inconsistent regarding the psychological impact of a prenatal versus a postnatal diagnosis. The aim of this study was to evaluate the influence of the time of diagnosis on levels of parental distress.Methods:Pregnant women and their partners with a fetus diagnosed with complex CHD, parents of children with postnatally diagnosed CHD, and pregnant women and their partners with uncomplicated pregnancies were invited to participate. Data were collected during pregnancy and 2–6 months after delivery using the Hospital Anxiety and Depression Scale, sense of coherence, life satisfaction, and Dyadic Adjustment Scale.Results:During pregnancy, the prenatal group scored lower sense of coherence compared to controls (p=0.044). Postnatally the prenatal group scored lower on sense of coherence compared to the postnatal group and controls (p=0.001; p=0.001). Postnatally, the prenatal and postnatal groups had higher levels of anxiety compared to controls (p=0.025; p=0.0003). Life satisfaction was lower in the prenatal group compared to that in the postnatal group and in controls (p=0.000; p=0.0004).Conclusion:Parents with a prenatal diagnosis of CHD in offspring report a low sense of coherence already during pregnancy which decreased further at follow-up. The same group reported a lower satisfaction with life compared to parents of a child with postnatal diagnosis of CHD and parents of a healthy child. This motivates further efforts to improve counselling and support during pregnancy and for parents after a prenatal diagnosis.

scholarly journals Diagnostic value of systematic ultrasonography for trisomy 18 syndrome in fetuses before 16 weeks gestation

2021 ◽  
Author(s):  
Jie Zhou ◽  
Xiaohui Dai ◽  
Hanmin Liu ◽  
Yiping Li ◽  
Ling Luo ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Birth Rate ◽  
Nuchal Translucency ◽  
Diagnostic Value ◽  
Cystic Hygroma ◽  
Trisomy 18 ◽  
Ductus Venosus ◽  
Research Subjects ◽  
Fetal Ultrasonography ◽  
Cardiac Defects

Abstract Purpose To explore the diagnostic value of systematic fetal ultrasonography for trisomy 18 (T18) syndrome before 16 weeks gestation. Methods A total of 12 fetuses with T18 were selected as research subjects and their nuchal translucency (NT) screening and fetal systematic ultrasonographic images acquired at 11–15 weeks were retrospectively analyzed. Results In the 12 fetuses’ NT screening, ten fetuses showed NT thickening, one showed nuchal cystic hygroma, four showed reversed a-wave ductus venosus flow, and three showed omphalocele. The most common anomalies on the systematic ultrasonography before 16 weeks gestation were cardiac defects (12/12, 100%), omphalocele (4/12, 33.3%), limb anomalies (5/12, 41.7%), and facial anomalies (3/12, 25.0%). Seven of the 12 fetuses had multiple structural malformations: three had two structural malformations (25.0%), three had three structural malformations (25.0%), and one had four structural malformations (8.3%). Conclusion Systematic fetal ultrasonography before 16 weeks gestation can detect most of the structural malformations of T18, effectively shortening the prenatal diagnosis time. It is therefore of great importance for reducing the birth rate of children with T18 and minimizing the physical and mental damage to mothers and their families.

scholarly journals Postnatal diagnosis of de novo complex der(8) in a boy with prenatal diagnosis of recombinant chromosome 8 syndrome

2019 ◽  
Vol 7 (5) ◽  
pp. 898-902
Author(s):  
Marina S. Oren ◽  
Jenny E. Camacho ◽  
Hongyan Xie ◽  
Jean Lowe ◽  
Tom Cushing ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
De Novo ◽  
Chromosome 8 ◽  
Recombinant Chromosome ◽  
Postnatal Diagnosis

Impact of prenatal diagnosis on the management and early outcome of critical duct-dependent cardiac lesions

2018 ◽  
Vol 28 (4) ◽  
pp. 548-553 ◽  
Author(s):  
Varsha Thakur ◽  
Nathalie Dutil ◽  
Steven M. Schwartz ◽  
Edgar Jaeggi
Keyword(s):  
Prenatal Diagnosis ◽  
Gestational Age ◽  
Cardiac Events ◽  
Time Intervals ◽  
Intention To Treat ◽  
Postnatal Diagnosis ◽  
Vasoactive Medication ◽  
Life Threatening ◽  
Cardiac Lesions ◽  
Study Inclusion

AbstractObjectiveThe objective of this study was to compare the preoperative management and outcome of neonates with duct-dependent critical CHD with fetal versus postnatal diagnosis.MethodsPatients referred with CHD to our centre from January 1, 2009 to December 31, 2010 were enrolled prospectively. Live births with a critical form of CHD, a gestational age ⩾36 weeks and a weight ⩾2 kg at birth, and the intention-to-treat were included in this sub-study. Excluded were neonates with lethal non-cardiac and/or genetic anomalies.ResultsIn total, 129, 63 fetal and 66 postnatal, cases met the study inclusion criteria. All had received appropriate antenatal care, including a routine fetal anatomy scan. Both cohorts were comparable in weight, gestational age, and APGAR scores at birth. Unlike the postnatal cases, there were no deaths (0/63 versus 5/66; p=0.06) and no cardiac arrests (0/63 versus 9/63; p=0.003) before surgery or catheter intervention in those cases with a prenatal diagnosis of critical CHD. Moreover, newborns with fetal diagnoses were admitted earlier (median 0 (range 0–3) versus 2 (0–25) days; p<0.001) and were less likely to require preoperative ventilation (19/63 versus 31/61, p=0.03) and vasoactive medication (4/63 versus 15/61, p=0.006) than the postnatal cases.ConclusionsPrenatal diagnosis of critical CHD in this study was associated with significantly shorter time intervals from birth to neonatal admission and the absence of life-threatening or fatal preoperative cardiac events. Increased efforts should be made to improve rates of prenatal diagnosis.

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