Communicating Down syndrome risk according to maternal age: “1-in-X ” effect on perceived risk

2015 ◽  
Vol 35 (8) ◽  
pp. 777-782 ◽  
Author(s):  
Stefania Pighin ◽  
Lucia Savadori ◽  
Elisa Barilli ◽  
Silvia Galbiati ◽  
Maddalene Smid ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Perceived Risk ◽  
Maternal Age ◽  
Down Syndrome Risk

MATERNAL AGE AND DOWN SYNDROME

The Lancet ◽  
1978 ◽  
Vol 312 (8082) ◽  
pp. 213 ◽  
Author(s):  
M.A. Ferguson-Smith
Keyword(s):  
Down Syndrome ◽  
Maternal Age

The incidence of Down syndrome in northern Finland with special reference to maternal age

2008 ◽  
Vol 27 (3) ◽  
pp. 252-257 ◽  
Author(s):  
J. Leisti ◽  
L. Vahtola ◽  
S.-L. Linna ◽  
R. Herva ◽  
S.-L. Koskela ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Special Reference ◽  
Maternal Age

619 Down syndrome risk reduction after normal genetic sonography

2001 ◽  
Vol 185 (6) ◽  
pp. S248
Author(s):  
Anthony Vintzileos ◽  
Edwin Guzman ◽  
John Smulian ◽  
Lami Yeo ◽  
William Scorza ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Risk Reduction ◽  
Down Syndrome Risk

scholarly journals Amniocentesis increases level of anxiety in women with invasive prenatal diagnosis of Down syndrome

2015 ◽  
Vol 34 (2) ◽  
pp. 112 ◽  
Author(s):  
Yanuarita Tursinawati ◽  
Serene Thain ◽  
Christina Choi ◽  
George Heong Yeo Seow
Keyword(s):  
Down Syndrome ◽  
Prenatal Diagnosis ◽  
Pregnant Women ◽  
Gestational Age ◽  
Perceived Risk ◽  
Linear Regression Analysis ◽  
Chorionic Villus ◽  
Chorionic Villus Sampling ◽  
Psychological Responses ◽  
Depression Anxiety Stress Scale

Backgound <br />Invasive prenatal diagnosis (PND) through amniocentesis and chorionic villus sampling (CVS) can detect Down syndrome. Pregnant women usually experience a variety of psychological responses associated with invasive PND. This study is intended to assess depression, anxiety and stress levels and the factors related to their psychological responses in pregnant women with invasive prenatal diagnosis of Down syndrome.<br /><br />Methods <br />A cross sectional study was conducted at Kandang Kerbau Women’s and Children’s Hospital, Singapore. The psychological responses of 70 women undergoing PND were assessed by Depression Anxiety Stress Scale 21 (DASS 21) questionnaire. A multiple linear regression analysis was used to analyze association between knowledge and perceived risk with psychological responses (CI 95% and significance value p&lt;0.05).<br /><br />Results <br />More than half of the participants had normal anxiety (55.7%), stress (72.8%), depression levels (65.8%). The results revealed significantly higher level of anxiety in women with gestational age &gt;13 weeks who had pursued amniocentesis. Women with no previous children had higher levels of depression and stress. Women who pursued amniocentesis had significantly higher anxiety scores compared to women undergoing CVS (p=0.015).<br /><br />Conclusions <br />Women’s psychological responses are associated with gestational age, type of procedure and parity. The level of anxiety increased in women who underwent amniocentesis for diagnosis of Down syndrome. Knowledge and perceived risk of having a baby with Down syndrome do not seem to have psychological effects to women.

scholarly journals Fetal Down syndrome screening models for developing countries; Part II: Cost-benefit analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chanane Wanapirak ◽  
Piyaluk Buddhawongsa ◽  
Woraluck Himakalasa ◽  
Auttapan Sarnwong ◽  
Theera Tongsong
Keyword(s):  
Developing Countries ◽  
Down Syndrome ◽  
Maternal Age ◽  
Cost Benefit Analysis ◽  
National Policy ◽  
Cost Benefit ◽  
Second Trimester ◽  
Benefit Analysis ◽  
Low Resource ◽  
Secondary Screening

Abstract Background To identify the most cost-beneficial model as a national policy of screening and diagnosis of fetal Down syndrome (DS) in developing countries. Methods Cost-benefit analysis (CBA) was performed based on the effectiveness and probabilities derived from a large prospective study on MSS (maternal serum screening) among Thai population. Various models including maternal age alone, STS (second trimester screen), I-S (independent screen: first or second trimester screen depending on the time of first visit), C-S (contingent serum screen) plus STS, maternal age with NIPS (non-invasive prenatal test), STS alone with NIPS, I-S with NIPS, C-S plus STS with NIPS, and Universal NIPS were compared. Results I-S with NIPS as a secondary screening was most cost-beneficial (Benefit/Cost ratio 4.28). Cost-benefit is directly related to the costs of NIPS. Conclusion In addition to simplicity and feasibility, I-S with expensive NIPS as a secondary screening is the most cost-beneficial method for low resource settings and should be included in universal healthcare coverage as a national policy. This study could be a model for developing countries or a guideline for international health organizations to help low resource countries, probably leading to a paradigm shift in prenatal diagnosis of fetal DS in the developing world.

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