Association of periventricular nodular heterotopia with posterior fossa cyst: a prenatal case series

2015 ◽  
Vol 35 (4) ◽  
pp. 337-341 ◽  
Author(s):  
Sara R. Teixeira ◽  
Eléonore Blondiaux ◽  
Marie Cassart ◽  
Alain Couture ◽  
Marie-Laure Moutard ◽  
...  
Keyword(s):  
Posterior Fossa ◽  
Case Series ◽  
Periventricular Nodular Heterotopia ◽  
Posterior Fossa Cyst ◽  
Nodular Heterotopia

scholarly journals Magnetic resonance–guided laser interstitial thermal therapy for pediatric periventricular nodular heterotopia-related epilepsy

2021 ◽  
pp. 1-6
Author(s):  
Vijay M. Ravindra ◽  
Sungho Lee ◽  
David Gonda ◽  
Ilana Patino ◽  
Lucia Ruggieri ◽  
...  
Keyword(s):  
Phase Ii ◽  
Focal Epilepsy ◽  
Surgical Techniques ◽  
Case Series ◽  
Median Number ◽  
Thermal Therapy ◽  
Invasive Approach ◽  
Periventricular Nodular Heterotopia ◽  
Laser Interstitial Thermal Therapy ◽  
Nodular Heterotopia

OBJECTIVE Periventricular nodular heterotopia (PVNH) is a result of disrupted neuronal migration from the ventricular system and can be a rare cause of refractory focal epilepsy. The goal of this case series was to describe the treatment of pediatric PVNH-related epilepsy with MR-guided laser interstitial thermal ablation. METHODS Patients treated at a single institution with MR-guided laser interstitial thermal therapy (MRgLITT) for PVNH-related epilepsy were identified. Preoperative and postoperative seizure outcomes and procedural information were evaluated. RESULTS Five children with PVNH treated with MRgLITT were reviewed; 1 child was treated twice. Three patients were female; the median age was 10.9 years. Five of 6 treatments were preceded by stereoelectroencephalography phase II monitoring. Three children experienced unilateral PVNH, and 2 had bilateral seizures. The median number of seizures recorded during phase II monitoring was 2; the median number of ablation targets was 2 (range 1–4). All patients experienced a decrease in seizure frequency; 4 patients (80%) had an Engel class ≤ III at the last follow-up (range I–IV). One child experienced right hemianopia posttreatment. CONCLUSIONS This case series investigation has illustrated a novel, minimally invasive approach for treating pediatric PVNH-related epilepsy. Further study of this technique with comparison with other surgical techniques is warranted.

scholarly journals DANDY-WALKER SYNDROME;

2017 ◽  
Vol 24 (01) ◽  
pp. 47-50
Author(s):  
Qazi Muhammad Zeeshan ◽  
Muhammad Hashim ◽  
Syed Mohammad Maroof Hashmi ◽  
Mohammad Absar Anwar
Keyword(s):  
Posterior Fossa ◽  
Previous History ◽  
Case Series ◽  
Fracture Dislocation ◽  
Common Symptom ◽  
Mortality And Morbidity ◽  
Dandy Walker Malformation ◽  
Posterior Fossa Cyst ◽  
History Of ◽  
Walker Malformation

Introduction: Dandy-Walker Malformation is an inborn condition that includesthe triumvirate of cystic enlargement of the fourth ventricle, posterior fossa distension with riseof the tentorium and agenesis of cerebellar vermis. The purpose of this study is to determinethe Clinical presentation and associated complications, mortality and morbidity of patientundergoing placement of shunt with Y- connector in Dandy Walker Malformation. StudyDesign: Case Series comprised of 85 cases. Setting: Neurosurgery Ward of Tertiary CareHospital in Karachi. Period: February 2011 to December 2015. Methodology: All patients whowere presented in OPD with complaints reminiscent of DWM with accompanied Hydrocephalusand then underwent CT scan Brain without contrast to confirm the diagnosis were admitted.The patients who have previous history of operation and other co-morbid anomalies wereomitted. These patients undergo drainage of Ventricular system and Posterior Fossa cyst wasdone mutually via Dual Shunt including Ventricular-peritoneal and Cysto-peritoneal shunt withY connector. There were few complications and mortality after this surgical intervention whichwas noted for a month. All records were recorded and evaluated by SPSS v.20. Result: Avast majority of patients included were Female. The average age of patients was 2.5 years+/- 1 Standard Deviation. The chief complaint was Hydrocephalus, existing in all patients,after that cerebellar signs in 55 (64.7%) and other signs in 10 (11.8%) patients. Others signsincludes; milestones were delayed, atypical gait and few patients were suffered from psychiatricproblems. Complications which were observed were shunt; Fracture/Dislocation in 10 (11.8%),shunt blockage in 8 (9.4%), malpositioning is also 8 (9.4%), Intracranial Hemorrhage in 7(8.24%) patients and Infection in 10 (11.8%). These complications were observed within amonth of surgery. Unfortunately, two (2.35%) patient were also expired after surgical approach.Conclusion: It is concluded that Dandy Walker Malformation is categorized by a triumvirate.Hydrocephalus is a most common symptom and principal cause of referral to hospitals. Thecommonest difficulty acknowledged after shunting is Malfunction and shunt infections. Thelowest mortality is related to Dual Shunt with Y connector when compared to other approachesfor management of shunt with Y-connector. Thus, it is found to be a worthy decision in givenDWM patients.

scholarly journals Compound heterozygous variants in LAMC3 in association with posterior periventricular nodular heterotopia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Carla De Angelis ◽  
Alicia B. Byrne ◽  
Rebecca Morrow ◽  
Jinghua Feng ◽  
Thuong Ha ◽  
...  
Keyword(s):  
Cortical Development ◽  
Occipital Cortex ◽  
Compound Heterozygous ◽  
Valuable Insight ◽  
Periventricular Nodular Heterotopia ◽  
Case Presentation ◽  
Malformation Of Cortical Development ◽  
Nodular Heterotopia ◽  
Compound Heterozygous Variants ◽  
Insight Into

Abstract Background Periventricular nodular heterotopia (PNH) is a malformation of cortical development characterized by nodules of abnormally migrated neurons. The cause of posteriorly placed PNH is not well characterised and we present a case that provides insights into the cause of posterior PNH. Case presentation We report a fetus with extensive posterior PNH in association with biallelic variants in LAMC3. LAMC3 mutations have previously been shown to cause polymicrogyria and pachygyria in the occipital cortex, but not PNH. The occipital location of PNH in our case and the proposed function of LAMC3 in cortical development suggest that the identified LAMC3 variants may be causal of PNH in this fetus. Conclusion We hypothesise that this finding extends the cortical phenotype associated with LAMC3 and provides valuable insight into genetic cause of posterior PNH.

27. EEG-fMRI of nodule-cortex interaction during interictal spiking in periventricular nodular heterotopia

2009 ◽  
Vol 16 (11) ◽  
pp. 1533-1534
Author(s):  
JS Archer ◽  
DF Abbott ◽  
R Masterton ◽  
S Palmer ◽  
GD Jackson
Keyword(s):  
Periventricular Nodular Heterotopia ◽  
Nodular Heterotopia

Electroencephalographic Recordings of Focal Seizures in Patients Affected by Periventricular Nodular Heterotopia: Role of the Heterotopic Nodules in the Genesis of Epileptic Discharges

2004 ◽  
Vol 19 (3) ◽  
pp. 369-377
Author(s):  
Giorgio Battaglia ◽  
Silvana Franceschetti ◽  
Luisa Chiapparini ◽  
Elena Freri ◽  
Stefania Bassanini ◽  
...  
Keyword(s):  
Brain Regions ◽  
Periventricular Nodular Heterotopia ◽  
Focal Seizures ◽  
Ictal Eeg ◽  
Epileptic Discharges ◽  
Nodular Heterotopia ◽  
Eeg Recordings ◽  
Drug Resistant Epilepsy ◽  
Video Eeg

Patients affected by periventricular nodular heterotopia are frequently characterized by focal drug-resistant epilepsy. To investigate the role of periventricular nodules in the genesis of seizures, we analyzed the electroencephalographic (EEG) features of focal seizures recorded by means of video-EEG in 10 patients affected by different types of periventricular nodular heterotopia and followed for prolonged periods of time at the epilepsy center of our institute. The ictal EEG recordings with surface electrodes revealed common features in all patients: all seizures originated from the brain regions where the periventricular nodular heterotopia were located; EEG patterns recorded on the leads exploring the periventricular nodular heterotopia were very similar both at the onset and immediately after the seizure's end in all patients. Our data suggest that seizures are generated by abnormal anatomic circuitries, including the heterotopic nodules and adjacent cortical areas. The major role of heterotopic neurons in the genesis and propagation of epileptic discharges must be taken into account when planning surgery for epilepsy in patients with periventricular nodular heterotopia. ( J Child Neurol 2005;20:369—377).

Lung disease associated with periventricular nodular heterotopia and an FLNA mutation

2011 ◽  
Vol 54 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Alice Masurel-Paulet ◽  
Eric Haan ◽  
Elizabeth M. Thompson ◽  
Cyril Goizet ◽  
Christel Thauvin-Robinet ◽  
...  
Keyword(s):  
Lung Disease ◽  
Periventricular Nodular Heterotopia ◽  
Nodular Heterotopia

scholarly journals Nodule excitability in an animal model of periventricular nodular heterotopia: c-fos activation in organotypic hippocampal slices

Epilepsia ◽  
2015 ◽  
Vol 56 (4) ◽  
pp. 626-635 ◽  
Author(s):  
Emily T. Doisy ◽  
H. Jürgen Wenzel ◽  
Yi Mu ◽  
Danh V. Nguyen ◽  
Philip A. Schwartzkroin
Keyword(s):  
Animal Model ◽  
Hippocampal Slices ◽  
Periventricular Nodular Heterotopia ◽  
Nodular Heterotopia

Network of autoscopic hallucinations elicited by intracerebral stimulations of periventricular nodular heterotopia: an SEEG study

Cortex ◽  
2021 ◽  
Author(s):  
Flavius-Ionut Bratu ◽  
Irina Oane ◽  
Andrei Barborica ◽  
Cristian Donos ◽  
Constantin Pistol ◽  
...  
Keyword(s):  
Periventricular Nodular Heterotopia ◽  
Nodular Heterotopia

Adults posterior fossa anaplastic ependymoma, Case series and literature review

2021 ◽  
Author(s):  
Huang-I Hsu ◽  
Shu-Shong Hsu ◽  
Wen-Yuh Chung ◽  
Chi-Man Yip ◽  
Su-Hao Liu ◽  
...  
Keyword(s):  
Literature Review ◽  
Posterior Fossa ◽  
Case Series ◽  
Anaplastic Ependymoma
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