Association between first trimester absence of fetal nasal bone on ultrasound and Down syndrome

2002 ◽  
Vol 22 (10) ◽  
pp. 930-932 ◽  
Author(s):  
L. Otaño ◽  
H. Aiello ◽  
L. Igarzábal ◽  
T. Matayoshi ◽  
E.C. Gadow
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Fetal Nasal Bone

Fetal Nasal Bone Assessment in First Trimester Down Syndrome Screening

2008 ◽  
Vol 24 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Recep Has ◽  
Ibrahim Kalelioglu ◽  
Atil Yuksel ◽  
Lemi Ibrahimoglu ◽  
Hayri Ermis ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Fetal Nasal Bone ◽  
Bone Assessment ◽  
Down Syndrome Screening

The role of first-trimester fetal nasal bone in screening for down syndrome in the korean population

2006 ◽  
Vol 195 (6) ◽  
pp. S183
Author(s):  
Jin Hoon Chung ◽  
Jae Hyug Yang ◽  
Moon-Young Kim ◽  
Hyun Mee Ryu ◽  
Min Hoan Moon ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Korean Population ◽  
Fetal Nasal Bone

FIRST AND SECOND TRIMESTER SONOGRAPHIC SCREENING FOR FETAL DOWN SYNDROME

2011 ◽  
Vol 22 (1) ◽  
pp. 45-66
Author(s):  
JULIA UNTERSCHEIDER ◽  
FERGAL D MALONE
Keyword(s):  
Down Syndrome ◽  
Screening Method ◽  
Chorionic Villus ◽  
Nasal Bone ◽  
First Trimester ◽  
Maternal Serum ◽  
Ductus Venosus ◽  
Chorionic Villus Sampling ◽  
Detection Rates ◽  
Fetal Nasal Bone

Screening for Down syndrome is an important part of routine antenatal care and should be made available, if requested, after appropriate counselling including risks and benefits, to all pregnant women, regardless of maternal age. Prenatal screening for fetal Down syndrome and other aneuploidies has advanced significantly since its advent in the 1980s. Historically, women 35 years or older were offered prenatal genetic counselling and the option of a diagnostic test such as chorionic villus sampling or amniocentesis. With this screening approach only 20% to 30% of the fetal Down syndrome population are detected antenatally. Sonographic and maternal biochemical markers are now used in combination to screen for aneuploidies in the first and second trimesters. The most common screening method in the first trimester combines the maternal serum markers HCG and PAPP-A with the sonographic evaluation of fetal nuchal translucency thickness. Newer markers have been proposed to further refine the risk assessment for Down syndrome to maximise detection rates and minimise false positive rates. These newer first trimester markers include sonographic assessment of the fetal nasal bone (NB), the frontomaxillary facial (FMF) angle, ductus venosus (DV) Doppler and tricuspid valve regurgitation (TR).

Practice Tips for Measuring the Nuchal Translucency

Ultrasound ◽  
2008 ◽  
Vol 16 (4) ◽  
pp. 220-225 ◽  
Author(s):  
Debbie Nisbet
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Nuchal Translucency ◽  
Operator Technique ◽  
Increased Risk ◽  
Fetal Nasal Bone ◽  
Form Part ◽  
The Uk ◽  
Bone Assessment ◽  
Down Syndrome Screening

In some countries, measurement of nuchal translucency (NT) is incorporated into national antenatal screening programmes to help detect pregnancies at increased risk of Down syndrome. Accurate measurement of the NT requires a specific technique. This article is an illustrated practical guide outlining the steps required for measuring the NT; it provides useful tips for improving operator technique and advises how to avoid common pitfalls. Although fetal nasal bone assessment does not currently form part of official Down syndrome screening programmes (in Australia or the UK), it is included here as debate about its usefulness continues.

First-trimester examination of fetal nasal bone in the Chinese population

2006 ◽  
Vol 26 (8) ◽  
pp. 703-706 ◽  
Author(s):  
Min Chen ◽  
Chin Peng Lee ◽  
Rebecca Tang ◽  
Ben Chan ◽  
Chun Quan Ou ◽  
...  
Keyword(s):  
Chinese Population ◽  
Nasal Bone ◽  
First Trimester ◽  
Fetal Nasal Bone

First-trimester screening for trisomy-21 using a simplified method to assess the presence or absence of the fetal nasal bone

2005 ◽  
Vol 192 (4) ◽  
pp. 1107-1111 ◽  
Author(s):  
Francesco Orlandi ◽  
Cinzia Rossi ◽  
Emanuela Orlandi ◽  
Maria Cristina Jakil ◽  
Terrence W. Hallahan ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Nasal Bone ◽  
First Trimester ◽  
First Trimester Screening ◽  
Fetal Nasal Bone ◽  
Simplified Method ◽  
Trimester Screening
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