First-trimester Down syndrome screening in renal-transplanted pregnant women: a model for adjusting the false-positives rates

2013 ◽  
Vol 33 (5) ◽  
pp. 467-470 ◽  
Author(s):  
Maribel Grande ◽  
Vicenç Cararach ◽  
Elena Casals ◽  
Antoni Borrell
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
First Trimester ◽  
False Positives ◽  
Down Syndrome Screening

Genetic Sonography After First-trimester Down Syndrome Screening

2007 ◽  
Vol 62 (9) ◽  
pp. 571-573
Author(s):  
D A. Krantz ◽  
T W. Hallahan ◽  
V J. Macri ◽  
J N. Macri
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Down Syndrome Screening

Fetal Nasal Bone Assessment in First Trimester Down Syndrome Screening

2008 ◽  
Vol 24 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Recep Has ◽  
Ibrahim Kalelioglu ◽  
Atil Yuksel ◽  
Lemi Ibrahimoglu ◽  
Hayri Ermis ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Fetal Nasal Bone ◽  
Bone Assessment ◽  
Down Syndrome Screening

scholarly journals The Effect of Down Syndrome Biochemical Markers on Predicting Severity of Preeclampsia

2020 ◽  
Author(s):  
AYSE OZBAN
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tests ◽  
Second Trimester ◽  
Study Results ◽  
Second Trimester Screening ◽  
Trimester Screening

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

Gender impact on first trimester markers in Down syndrome screening

2002 ◽  
Vol 22 (13) ◽  
pp. 1207-1208 ◽  
Author(s):  
Severin Olesen Larsen ◽  
Karen R. Wøjdemann ◽  
Anne-Cathrine Shalmi ◽  
Karin Sundberg ◽  
Michael Christiansen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Down Syndrome Screening

Uptake of Noninvasive Prenatal Testing in Chinese Women following Positive Down Syndrome Screening

2014 ◽  
Vol 37 (2) ◽  
pp. 141-147 ◽  
Author(s):  
C.F. Poon ◽  
W.C. Tse ◽  
K.O. Kou ◽  
K.Y. Leung
Keyword(s):  
Down Syndrome ◽  
Chinese Women ◽  
Multivariable Analysis ◽  
Chorionic Villus ◽  
Prenatal Testing ◽  
First Trimester ◽  
Screening Methods ◽  
Chorionic Villus Sampling ◽  
Noninvasive Prenatal Testing ◽  
Down Syndrome Screening

Objectives: To investigate how the introduction of noninvasive prenatal testing (NIPT) influenced women's testing choices following a positive Down syndrome screening. Methods: A retrospective study was conducted to compare differences in the uptake rates of invasive prenatal diagnosis (IPD) or no testing in one public hospital 1 year before (pre-NIPT) and 1 and 2 years after the introduction of NIPT in private in August 2011 using descriptive analysis and a χ2 test. Conventional screening was funded publicly, but NIPT was not. Multivariable binary logistic regression was used to determine factors affecting choices. Results: In pre-NIPT and in years 1 and 2 after the introduction of NIPT, 306, 362 and 401 women who screened positive were seen, respectively. In year 1 and year 2, 12.6 and 26.7% of them underwent NIPT while IPD was decreased by 16.3 and 25.6%, respectively (p < 0.001). Both chorionic villus sampling and amniocentesis decreased in year 1, but only the former in year 2. However, the rate of declining further testing was similar before and after NIPT (p = 0.213). In multivariable analysis, first trimester screening, nulliparity and working women were significant predictors of accepting NIPT, while only nulliparity was a predictor of declining IPD (OR = 0.61). Conclusions: Introduction of NIPT resulted in a significant decrease in IPD for 2 consecutive years.

scholarly journals Genetic sonography after first-trimester Down syndrome screening

2007 ◽  
Vol 29 (6) ◽  
pp. 666-670 ◽  
Author(s):  
D. A. Krantz ◽  
T. W. Hallahan ◽  
V. J. Macri ◽  
J. N. Macri
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Down Syndrome Screening
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