Prenatal diagnosis and carrier detection for Athabascan severe combined immunodeficiency disease

2002 ◽  
Vol 22 (9) ◽  
pp. 763-768 ◽  
Author(s):  
Lanying Li ◽  
Yungui Zhou ◽  
Junhua Wang ◽  
Diana Hu ◽  
Morton J. Cowan
Keyword(s):  
Prenatal Diagnosis ◽  
Severe Combined Immunodeficiency ◽  
Carrier Detection ◽  
Combined Immunodeficiency ◽  
Immunodeficiency Disease ◽  
Severe Combined Immunodeficiency Disease

Review: Why screen for severe combined immunodeficiency disease?

2020 ◽  
Vol 27 (8) ◽  
pp. 485-489
Author(s):  
C. Thomas ◽  
G. Hubert ◽  
A. Catteau ◽  
M. Danielo ◽  
V.P. Riche ◽  
...  
Keyword(s):  
Severe Combined Immunodeficiency ◽  
Combined Immunodeficiency ◽  
Immunodeficiency Disease ◽  
Severe Combined Immunodeficiency Disease

scholarly journals Parallel tubular arrays in severe combined immunodeficiency disease: an ultrastructural study of peripheral blood lymphocytes

Blood ◽  
1977 ◽  
Vol 50 (1) ◽  
pp. 55-64 ◽  
Author(s):  
CM Payne ◽  
JF Jones ◽  
OF Jr Sieber ◽  
VA Fulginiti
Keyword(s):  
Ultrastructural Study ◽  
Peripheral Blood ◽  
Severe Combined Immunodeficiency ◽  
Peripheral Blood Lymphocytes ◽  
Combined Immunodeficiency ◽  
Circulating Lymphocytes ◽  
Membrane Bound ◽  
Immunodeficiency Disease ◽  
Severe Combined Immunodeficiency Disease ◽  
Tubular Arrays

Abstract The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these inclusions was quite variable, with some attaining a length of 1.7 micrometer. They contained a tubular substructure with a diameter of 36--44 nm. The PTA were mostly located in the centriolar and Golgi regions of the cytoplasm, and were sometimes membrane bound. A centriolar origin of the inclusion was suggested. A second inclusion, the tubuloreticular structure, was found in only 1.4% of the circulating lymphocytes from one SCID patient. The origin of the PTA and its occurrence in severe combined immunodeficiency disease are discussed.

Sign in / Sign up

Export Citation Format

Share Document