The stability of free-β human chorionic gonadotrophin and pregnancy-associated plasma protein-A in first trimester dried blood spots

2011 ◽  
Vol 31 (3) ◽  
pp. 293-298 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Anastasia Stamatopoulou ◽  
Paivi Liitti ◽  
Mikko Suonpaa ◽  
Kevin Spencer
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Dried Blood Spots ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Blood Spots ◽  
The Stability

Performance of free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands

2009 ◽  
Vol 47 (2) ◽  
Author(s):  
Ingeborg H. Linskens ◽  
Marieke Levitus ◽  
Anneke Frans ◽  
Peter C.J.I. Schielen ◽  
John M.G. van Vugt ◽  
...  
Keyword(s):  
The Netherlands ◽  
Plasma Protein ◽  
Screening Program ◽  
Medical Center ◽  
Protein A ◽  
First Trimester ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Serum Samples ◽  
Β Hcg

Abstract: The VU University Medical Center (VUmc) was the first hospital in the Netherlands to introduce the Delfia Xpress for the analysis of free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester screening program for Down syndrome. Since then, others have implemented this system. In this study, we tested the equality of measurements for free β-hCG and PAPP-A between Delfia Xpress systems and one AutoDelfia system.: A total of 40 serum samples were aliquoted and stored at –20°C. Samples were analyzed by six Delfia Xpress systems and one AutoDelfia system over a time period of 2 years.: The relationships between free β-hCG and PAPP-A were excellent for the different Delfia Xpress systems (r>0.99, p<0.0001). For PAPP-A, the agreement between the main system at VUmc and five other systems was linear with slopes between 0.99 and 1.06. Similarly, agreement for free β-hCG was linear with slopes between 0.99 and 1.09. Likewise, agreement for PAPP-A and free β-hCG was excellent for the AutoDelfia vs. the main Delfia Xpress at the VUmc (r>0.99, p<0.0001). For both PAPP-A and free β-hCG, the relationships were linear with slopes of 1.08 and 1.07.: We demonstrate an excellent agreement for the analysis of PAPP-A and free β-hCG between Delfia Xpress systems and one AutoDelfia system.Clin Chem Lab Med 2009;47:222–6.

Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A in twin pregnancies in the first trimester

2002 ◽  
Vol 22 (3) ◽  
pp. 183-185 ◽  
Author(s):  
Marko Niemimaa ◽  
Mikko Suonpää ◽  
Seppo Heinonen ◽  
Maija Seppälä ◽  
Risto Bloigu ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Maternal Serum ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Twin Pregnancies

Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein a, markers for fetal down syndrome at 8–14 weeks

1994 ◽  
Vol 14 (3) ◽  
pp. 203-208 ◽  
Author(s):  
M. C. M. Macintosh ◽  
R. Iles ◽  
B. Teisner ◽  
K. Sharma ◽  
T. Chard ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Plasma Protein ◽  
Protein A ◽  
Maternal Serum ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin
Sign in / Sign up

Export Citation Format

Share Document