Congenital diaphragmatic hernia in a first-trimester ultrasound aneuploidy screening program

2008 ◽  
Vol 28 (6) ◽  
pp. 531-534 ◽  
Author(s):  
Waldo Sepulveda ◽  
Amy E. Wong ◽  
Alexandra Casasbuenas ◽  
Aldo Solari ◽  
Juan L. Alcalde
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Screening Program ◽  
First Trimester ◽  
Aneuploidy Screening ◽  
First Trimester Ultrasound

First trimester ultrasound diagnosis of congenital diaphragmatic hernia

2007 ◽  
Vol 33 (6) ◽  
pp. 870-872 ◽  
Author(s):  
George Daskalakis ◽  
Eleftherios Anastasakis ◽  
Athena Souka ◽  
Asimina Manoli ◽  
Chrisovalandis Koumpis ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
First Trimester ◽  
Ultrasound Diagnosis ◽  
First Trimester Ultrasound

scholarly journals Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

2019 ◽  
Vol 122 (11) ◽  
pp. 1295-1302 ◽  
Author(s):  
Takehiro Michikawa ◽  
Shin Yamazaki ◽  
Makiko Sekiyama ◽  
Tatsuo Kuroda ◽  
Shoji F. Nakayama ◽  
...  
Keyword(s):  
Vitamin A ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Dietary Habits ◽  
Daily Intake ◽  
First Trimester ◽  
Dietary Vitamin ◽  
Birth Cohort Study ◽  
Case Control Studies ◽  
Total Vitamin

AbstractThe pathogenesis of congenital diaphragmatic hernia (CDH) is largely unknown; however, vitamin A seems to play a role in diaphragmatic development. Previous case–control studies reported that maternal dietary vitamin A intake was inversely associated with the risk of CDH. To our knowledge, however, there is no prospective evidence regarding this association. Our aim was to examine whether maternal intake of vitamin A was associated with CDH occurrence. Baseline data, from the Japan nationwide birth cohort study (2011–2014) of 89 658 mothers (mean age at delivery = 31·2 years) who delivered singleton live births, were analysed. We assessed dietary habits using an FFQ focused on the first trimester and estimated the daily intake of total vitamin A (retinol activity equivalents), retinol, provitamin A carotenoids and vegetables. The occurrence of CDH was ascertained from medical records. A total of forty cases of CDH were documented. The adjusted OR of CDH occurrence for the high total vitamin A intake category (median = 468 μg/d) was 0·6 (95 % CI 0·3, 1·2) with reference to the low intake category (230 μg/d). When we restricted to mothers with a prepregnancy BMI of 18·5–24·9 kg/m2, vitamin A intake was inversely associated with the risk of their children being born with CDH (OR 0·5, 95 % CI 0·2, 1·0). Even given the limited number of cases in the study, our findings provide additional evidence to link vitamin A with CDH.

scholarly journals First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Cláudia Teixeira ◽  
Eduardo Tejera ◽  
Helena Martins ◽  
António Tomé Pereira ◽  
Altamiro Costa-Pereira ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Late Onset ◽  
Screening Program ◽  
First Trimester ◽  
University Hospital ◽  
Aneuploidy Screening ◽  
Detection Rates ◽  
Crown Rump Length ◽  
Screening Programs ◽  
Obstetric Population

Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions.Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013. Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (freeβ-hCG).Results. At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively. Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, freeβ-hCG, CRL, and NT, but not PAPP-A, for prediction of PE.Conclusion. Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening. However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs.

Aneuploidy Screening: The Ongoing Role of First-Trimester Ultrasound

2016 ◽  
pp. 131-152
Author(s):  
Kristen M. Rauch ◽  
Melissa A. Hicks ◽  
Henry Adekola ◽  
Jacques S. Abramowicz
Keyword(s):  
First Trimester ◽  
Aneuploidy Screening ◽  
First Trimester Ultrasound

scholarly journals P02.43: Congenital diaphragmatic hernia diagnosed in the first trimester

2006 ◽  
Vol 28 (4) ◽  
pp. 532-533
Author(s):  
G. Daskalakis ◽  
A. Souka ◽  
E. Anastasakis ◽  
N. Papantoniou ◽  
M. Theodora ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
First Trimester

scholarly journals P34.12: Congenital diaphragmatic hernia detection during first trimester screening

2010 ◽  
Vol 36 (S1) ◽  
pp. 303-303
Author(s):  
G. Sepulveda Gonzalez ◽  
C. Flores Acosta ◽  
G. Treviño Martínez ◽  
A. Guzmán López ◽  
M. Smith Doria
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening
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