Sequential first and second trimester screening tests: correlation of the markers' levels in normal versus Down syndrome affected pregnancies

2001 ◽  
Vol 21 (13) ◽  
pp. 1175-1177 ◽  
Author(s):  
R. Maymon ◽  
M. Bergman ◽  
S. Segal ◽  
E. Dreazen ◽  
Z. Weinraub ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Screening Tests ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

scholarly journals The Effect of Down Syndrome Biochemical Markers on Predicting Severity of Preeclampsia

2020 ◽  
Author(s):  
AYSE OZBAN
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tests ◽  
Second Trimester ◽  
Study Results ◽  
Second Trimester Screening ◽  
Trimester Screening

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

First-Trimester or Second-Trimester Screening, or Both, for Down Syndrome

2021 ◽  
pp. 108-114
Author(s):  
Jessica M. Hart ◽  
Barbara M. O’Brien
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Nuchal Translucency ◽  
The United States ◽  
Screening Tests ◽  
Second Trimester ◽  
Detection Rates ◽  
Fully Integrated ◽  
Second Trimester Screening ◽  
Trimester Screening

The FASTER Trial by Malone et al. discusses methods of prenatal genetic screening for Down syndrome. The trial included 15 sites within the United States between 1999 and 2005. This trial was designed to compare the differences in detection rates of Down syndrome when applying screening tests from the first-trimester, second-trimester, or screening tests that combine markers from both trimesters. Screening tests evaluated in this trial include nuchal translucency, serum screen, combined screen, quadruple screen, independent sequential screen, stepwise sequential screen, serum integrated screen, and fully integrated screen. This trial compares detection rates, false positive rates, and timing of results between screening tests.

P397 Step-wise first and second trimester screening for Down syndrome

2009 ◽  
Vol 107 ◽  
pp. S526-S527 ◽  
Author(s):  
D. Smetanova ◽  
E. Kulovany ◽  
M. Hynek ◽  
M. Matouskova ◽  
D. Stejskal
Keyword(s):  
Down Syndrome ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Combined first- and second-trimester screening for Down syndrome: an evaluation of proMBP as a marker

2003 ◽  
Vol 23 (7) ◽  
pp. 593-598 ◽  
Author(s):  
Line Rode ◽  
Karen R. Wøjdemann ◽  
Anne-Cathrine Shalmi ◽  
Severin Olesen Larsen ◽  
Karin Sundberg ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Levels of urinary beta-core fragment, total oestriol, and the ratio of the two in second-trimester screening for Down syndrome

1997 ◽  
Vol 17 (12) ◽  
pp. 1135-1141 ◽  
Author(s):  
Leonard H. Kellner ◽  
Jacob A. Canick ◽  
Glenn E. Palomaki ◽  
Louis M. Neveux ◽  
Devereux N. Saller ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Second Trimester ◽  
Core Fragment ◽  
Second Trimester Screening ◽  
Trimester Screening
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