Serum alpha-fetoprotein and neural tube defects in the first trimester of pregnancy

1993 ◽  
Vol 13 (11) ◽  
pp. 1047-1050 ◽  
Author(s):  
Nicholas J. Wald ◽  
Allan Hackshaw ◽  
Rossana Stone ◽  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein ◽  
First Trimester Of Pregnancy

scholarly journals ETERNAL SERUM ALPHA-FETOPROTEIN (AFP) SCREENING FOR NEURAL TUBE DEFECTS (NTDS)

1977 ◽  
Vol 11 (4) ◽  
pp. 528-528 ◽  
Author(s):  
Aubrey Milunsky ◽  
Elliot Alpert ◽  
Frederic O Frigoletto
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein

First-Trimester Screening for Neural Tube Defects Using Alpha-Fetoprotein

2012 ◽  
Vol 31 (2) ◽  
pp. 109-114 ◽  
Author(s):  
F.E. Bredaki ◽  
L.C. Poon ◽  
C. Birdir ◽  
D. Escalante ◽  
K.H. Nicolaides
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Alpha Fetoprotein ◽  
First Trimester Screening ◽  
Trimester Screening

Valproate Teratogenicity

PEDIATRICS ◽  
1983 ◽  
Vol 71 (6) ◽  
pp. 980-980
Author(s):  
Keyword(s):  
Valproic Acid ◽  
Disease Control ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Prenatal Testing ◽  
First Trimester ◽  
Teratogenic Effects ◽  
Recent Statement ◽  
Estimated Risk ◽  
First Trimester Of Pregnancy

In a recent statement entitled, "Valproic Acid: Benefits and Risks" we reported that despite the presence of teratogenic effects in animals there existed only one possible case in man.1 Recently the Centers for Disease Control has reported that the use of valproic acid (Depakene), during the first trimester of pregnancy, may increase the risk of having a child with spina bifids.2 The report, based upon a study undertaken in Rhône-Alpes, France,3,4 quotes an estimated risk of 1.2%. Based upon this information, we believe that a woman who becomes pregnant while on valproic acid should consult with her physician about prenatal testing for neural tube defects. Additional recommendations for the counseling of women who require anticounvulsant treatment during pregnancy have been published previously.5

scholarly journals Comparison of an ELISA with a RIA Method for Serum Alpha-Fetoprotein Determination in Screening for Fetal Neural Tube Defects

1986 ◽  
Vol 23 (3) ◽  
pp. 334-339 ◽  
Author(s):  
R D Barlow ◽  
S G Thompson ◽  
H S Cuckle ◽  
N J Wald ◽  
A Voller
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Alpha Fetoprotein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Antenatal Screening ◽  
Elisa Method ◽  
Suitable Alternative ◽  
Significant Difference ◽  
Serum Alpha Fetoprotein ◽  
Gestational Week

An enzyme-linked immunosorbent assay (ELISA) was evaluated for serum alpha-fetoprotein determination in the antenatal screening for fetal open neural tube defects. The ELISA was used concurrently with an existing radioimmunoassay (RIA) method until serum specimens from 5000 pregnant women, between 15 and 20 weeks gestation, had been tested. The accuracy of the ELISA was similar to that of the RIA; the median AFP values by gestational week obtained with the ELISA were, on average, 2 KIU/L higher than the corresponding RIA values; the 10th and 90th percentiles, in terms of multiples of the median (MoM), were very similar. The precision of the two methods was also similar. The ELISA method yielded 1·8% results from unaffected pregnancies above 2·5 MoM compared with 1·4% by RIA, a small but statistically significant difference ( P=0·03). Both methods detected the same affected pregnancies identified during this period; five open neural tube defects, three with exomphalos and three intra-uterine deaths. The ELISA method was simple, required about one quarter less operator time than the RIA and enabled results to be generated in one day rather than the two days required by RIA. The ELISA method is a suitable alternative to RIA for routine use in screening for fetal neural tube defects.

Maternal serum alpha-fetoprotein screening for neural tube defects and other disorders using an ultramicro-ELISA

1986 ◽  
Vol 73 (1) ◽  
pp. 60-63 ◽  
Author(s):  
Hannelore K�rner ◽  
Lidia Rodriguez ◽  
J. L. Fernandez Yero ◽  
Margarete Schulze ◽  
Anton Horn ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein
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