Shift of the fetal sex ratio in hCG selected pregnancies at risk for Down syndrome

1992 ◽  
Vol 12 (8) ◽  
pp. 703-704 ◽  
Author(s):  
Nathalie Leporrier ◽  
Michel Herrou ◽  
Pierre Leymarie
Keyword(s):  
At Risk ◽  
Down Syndrome ◽  
Sex Ratio ◽  
Fetal Sex

Fetal Sex Ratio in the Rhesus (Macaca mulatta)

1979 ◽  
Vol 31 (3) ◽  
pp. 246-250 ◽  
Author(s):  
R.F. DiGiacomo ◽  
P.W. Shaughnessy
Keyword(s):  
Sex Ratio ◽  
Fetal Sex

scholarly journals Diabetic Embryopathy in C57BL/6J Mice: Altered Fetal Sex Ratio and Impact of the Splotch Allele

Diabetes ◽  
2001 ◽  
Vol 50 (5) ◽  
pp. 1193-1199 ◽  
Author(s):  
A. F. Machado ◽  
E. F. Zimmerman ◽  
D. N. Hovland ◽  
R. Weiss ◽  
M. D. Collins
Keyword(s):  
Sex Ratio ◽  
Fetal Sex ◽  
Diabetic Embryopathy

Fetal sex ratio in relation to maternal mass and age in reindeer

1997 ◽  
Vol 75 (4) ◽  
pp. 648-650 ◽  
Author(s):  
Eigil Reimers ◽  
Dag Lenvik
Keyword(s):  
Natural Selection ◽  
Sex Ratio ◽  
Parental Investment ◽  
Similar Condition ◽  
Rangifer Tarandus ◽  
Good Condition ◽  
Maternal Condition ◽  
Fetal Sex ◽  
Poor Condition ◽  
Parental Ability

Theory suggests that a male in good condition at the end of the period of parental investment will outproduce a sister in similar condition, while she will outproduce him if both are in poor condition. Accordingly, natural selection should favor parental ability to adjust the sex ratio of offspring produced according to parental ability to invest. As maternal condition declines from good to poor, the fetal sex ratio should decline from a high proportion of males to a high proportion of females. Data from 1525 domestic reindeer (Rangifer tarandus) in six different herds slaughtered during December and January in 1976 through 1979 do not support a relationship between the sex of the fetus and either the condition of the mother or her age.

scholarly journals GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia

Blood ◽  
2013 ◽  
Vol 122 (24) ◽  
pp. 3908-3917 ◽  
Author(s):  
Irene Roberts ◽  
Kate Alford ◽  
Georgina Hall ◽  
Gaetan Juban ◽  
Helen Richmond ◽  
...  
Keyword(s):  
At Risk ◽  
Down Syndrome ◽  
Trisomy 21 ◽  
Population At Risk ◽  
Key Points

Key Points GATA1 mutations are common in neonates with Down syndrome but are often unsuspected and detectable only with sensitive methods. Multilineage blood abnormalities in all Down syndrome neonates in the absence of GATA1 mutations suggests that trisomy 21 itself perturbs hemopoiesis.

scholarly journals Transient Abnormal Myelopoeisis and Mosaic down Syndrome in a Phenotypically Normal Newborn

Children ◽  
2020 ◽  
Vol 7 (6) ◽  
pp. 52
Author(s):  
Zachary Prudowsky ◽  
HyoJeong Han ◽  
Alexandra Stevens
Keyword(s):  
At Risk ◽  
Down Syndrome ◽  
Early Diagnosis ◽  
Early Identification ◽  
Mutation Testing ◽  
Neonatal Complication ◽  
Transient Abnormal Myelopoiesis ◽  
Mosaic Down Syndrome ◽  
Gata1 Mutation

Transient abnormal myelopoiesis (TAM) is a common and potentially fatal neonatal complication of newborn babies with Down syndrome (DS). Children born with mosaic DS are also at risk of developing TAM. However, due to their variable phenotypes, early identification of patients with mosaic DS may be difficult; thus, early diagnosis of TAM is just as challenging. In this report, we describe a case of a phenotypically normal newborn who presented with concerns for neonatal leukemia. The diagnosis of mosaic DS and TAM was confirmed with abnormal GATA1 mutation testing, highlighting the importance of early GATA1 mutation testing in newborn leukemia with high suspicion for TAM.

Midtrimester sonographic findings for the prediction of down syndrome in a population at risk

2006 ◽  
Vol 195 (6) ◽  
pp. S193
Author(s):  
Patrizia Vergani ◽  
Alessandro Ghidini ◽  
Steven Weiner ◽  
Anna Biffi ◽  
Anna Locatelli ◽  
...  
Keyword(s):  
At Risk ◽  
Down Syndrome ◽  
Population At Risk
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