Trisomy 12 mosaicism in amniocytes and dysmorphic child despite normal chromosomes in fetal blood sample

1989 ◽  
Vol 9 (6) ◽  
pp. 433-437 ◽  
Author(s):  
Harriet von Koskull ◽  
Annukka Ritvanen ◽  
Pirkko Ämmälä ◽  
Nina Gahmberg ◽  
Riitta Salonen
Keyword(s):  
Blood Sample ◽  
Fetal Blood ◽  
Trisomy 12 ◽  
Fetal Blood Sample

A retrospective review of the management of an abnormal fetal blood sample in primigravidae patients treated with oxytocin in labour

2003 ◽  
Vol 23 (sup1) ◽  
pp. S67-S67
Author(s):  
T. Walsh ◽  
M. O'Connell ◽  
M. O'Leary ◽  
Catherine Mcquillan ◽  
C. O'Herlhy ◽  
...  
Keyword(s):  
Blood Sample ◽  
Retrospective Review ◽  
Fetal Blood ◽  
Fetal Blood Sample

A Simple and Rapid Method to Determine GPIIb/IIIa-Receptor Inhibitor Activity in Whole Blood

1999 ◽  
Vol 19 (03) ◽  
pp. 134-138
Author(s):  
Gitta Kühnel ◽  
A. C. Matzdorff
Keyword(s):  
Flow Cytometry ◽  
Platelet Count ◽  
Blood Sample ◽  
Platelet Activation ◽  
Whole Blood ◽  
Receptor Occupancy ◽  
Aggregate Formation ◽  
Inhibitor Activity ◽  
Receptor Inhibitor

SummaryWe studied the effect of GPIIb/IIIa-inhibitors on platelet activation with flow cytometry in vitro. Citrated whole blood was incubated with increasing concentrations of three different GPIIb/IIIa-inhibitors (c7E3, DMP728, XJ757), then thrombin or ADP were added and after 1 min the sample was fixed. Samples without c7E3 but with 0.1 U/ml thrombin had a decrease in platelet count. Samples with increasing concentrations of c7E3 had a lesser or no decrease in platelet count. The two other inhibitors (DMP 725, XJ757) gave similar results. GPIIb/IIIa-inhibitors prevent aggregate formation and more single platelets remain in the blood sample. The agonist-induced decrease in platelet count correlates closely with the concentration of the GPIIb/IIIa inhibitor and receptor occupancy. This correlation may be used as a simple measure for inhibitor activity in whole blood.

GRADIENTS OF MATERNAL AND FETAL BLOOD FLOW AT THREAT OF PREMATURE DELIVERY

2005 ◽  
Vol 26 (S 1) ◽  
Author(s):  
TL Botasheva ◽  
TA Zamanskaya ◽  
AV Orlov ◽  
SN Norits
Keyword(s):  
Blood Flow ◽  
Premature Delivery ◽  
Fetal Blood

222-OR: BETA-2 Calculated Based on Single Fasting Blood Sample Allows to Define and Discriminate between Optimal and Suboptimal Islet Allograft Function Prior to the Clinical Need for Insulin Support

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 222-OR
Author(s):  
PIOTR J. BACHUL ◽  
JUSTYNA E. GOLEBIEWSKA ◽  
FILIP ANTIC ◽  
MONICA PARA ◽  
LINDSAY BASTO ◽  
...  
Keyword(s):  
Blood Sample ◽  
Islet Allograft ◽  
Allograft Function ◽  
Beta 2

THE ROLE OF THE GENETIC ABNORMALITIES, EPIGENETIC AND microRNA IN THE PROGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA

2018 ◽  
Vol 40 (4) ◽  
pp. 261-267 ◽  
Author(s):  
K Tari ◽  
Z Shamsi ◽  
H Reza Ghafari ◽  
A Atashi ◽  
M Shahjahani ◽  
...  
Keyword(s):  
B Cells ◽  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitors ◽  
Bone Marrow Involvement ◽  
P53 Mutation ◽  
Lymphocytic Leukemia ◽  
Gene Promoters ◽  
Epigenetic Changes ◽  
Genetic Changes ◽  
Trisomy 12

Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL.

Assessing Zinc Amassing in Forages, Buffalo Blood and Topsoil Collected from Sargodha City, Pakistan

2020 ◽  
Vol 71 (8) ◽  
pp. 240-248
Author(s):  
Kafeel Ahmad ◽  
Yongjun Yang ◽  
Zafar Iqbal Khan ◽  
Nimra Arshad ◽  
Tasneem Ahmad ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Atomic Absorption ◽  
Blood Sample ◽  
Analysis Of Variance ◽  
Atomic Absorption Spectrophotometer ◽  
Metal Analysis ◽  
Heavy Metal Analysis

The article is focused on estimation of Zinc in the roadside forages, and blood of buffaloes feeding on these forages. This study was carried out in Sargodha during December 2015 to January 2016 (winter) and May 2016 to June 2016 (summer). Five road sites (Mateela, Faisalabad roadside, Shaheenabad roadside, Bhalwal roadside and 50 chak) were selected from sampling of forages, soil and buffalo blood sample. Heavy metal analysis of all digested samples was done with atomic absorption spectrophotometer. Analysis of variance and correlation was done with two way ANOVA. This study regarding the accumulation of zinc in forages, soil and the buffalo blood would help the authorities to exactly determine the agents which are responsible for increasing pollution in the environment.

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