Clinical outcome of treatment cycles using preimplantation genetic diagnosis for structural chromosomal abnormalities

2001 ◽  
Vol 21 (9) ◽  
pp. 781-787 ◽  
Author(s):  
Margareta Fridström ◽  
Lars Ährlund-Richter ◽  
Erik Iwarsson ◽  
Helena Malmgren ◽  
José Inzunza ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Preimplantation Genetic Diagnosis ◽  
Chromosomal Abnormalities ◽  
Genetic Diagnosis

Clinical outcome of preimplantation genetic diagnosis for chromosome translocations

2004 ◽  
Vol 82 ◽  
pp. S28-S29
Author(s):  
J.M. Cieslak ◽  
C. Lavin ◽  
V. Galat ◽  
V. Kuznetsova ◽  
A. Kuliev ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Preimplantation Genetic Diagnosis ◽  
Genetic Diagnosis ◽  
Chromosome Translocations

Preimplantation genetic diagnosis

2002 ◽  
Vol 10 (1) ◽  
pp. 3-20
Author(s):  
JDA Delhanty ◽  
JC Harper
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Chromosomal Abnormalities ◽  
Recurrent Miscarriage ◽  
Pregnancy Termination ◽  
Genetic Disorder ◽  
Single Gene ◽  
Genetic Diagnosis ◽  
Early Embryo ◽  
Knowing That

The aim of preimplantation genetic diagnosis (PGD) is to give couples at risk of passing on a genetic disorder an alternative to standard prenatal diagnosis by enabling them to start a pregnancy that is known to be free of the familial disease. This can be achieved by generating embryos in vitro by standard in vitro fertilization (IVF) techniques and then removing one to two of the cells from the early embryo (embryo biopsy). Single cell polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH) can then be used to diagnose single gene defects or chromosomal abnormalities respectively. Those embryos diagnosed as free from disease can then be considered for transfer to the womb and so the pregnancy is started knowing that the fetus is unaffected. This avoids the need to consider pregnancy termination in the quest for a healthy child. Originally it was thought that the major reason for referral would be the risk of passing on a single abnormal gene but an increasing proportion of couples are requesting PGD because of recurrent miscarriage due to parental chromosomal abnormality.

Sign in / Sign up

Export Citation Format

Share Document