ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome

2006 ◽  
Vol 26 (10) ◽  
pp. 973-979 ◽  
Author(s):  
Jennie Laigaard ◽  
Kevin Spencer ◽  
Michael Christiansen ◽  
Nicholas J. Cowans ◽  
Severin Olesen Larsen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Serum Marker ◽  
Maternal Serum ◽  
Adam 12

scholarly journals OP25.06: Maternal serum ADAM 12 levels in Down syndrome pregnancies during the first trimester

2007 ◽  
Vol 30 (4) ◽  
pp. 543-544
Author(s):  
M. Ryynanen ◽  
Y. Valinen ◽  
J. Ignatius ◽  
P. Laitinen ◽  
T. Ahola ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Maternal Serum ◽  
Adam 12

Human placental lactogen is a first-trimester maternal serum marker of Down syndrome

2006 ◽  
Vol 27 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Michael Christiansen ◽  
Tina Lindvig Sørensen ◽  
Bent Nørgaard-Pedersen
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Serum Marker ◽  
Maternal Serum ◽  
Placental Lactogen ◽  
Human Placental Lactogen

scholarly journals ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome

2007 ◽  
Vol 27 (7) ◽  
pp. 611-615 ◽  
Author(s):  
Michael Christiansen ◽  
Kevin Spencer ◽  
Jennie Laigaard ◽  
Nicholas J. Cowans ◽  
Severin Olesen Larsen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Serum Marker ◽  
Maternal Serum ◽  
Second Trimester ◽  
Adam 12

ADAM12: a novel first-trimester maternal serum marker for Down syndrome

2003 ◽  
Vol 23 (13) ◽  
pp. 1086-1091 ◽  
Author(s):  
Jennie Laigaard ◽  
Tina Sørensen ◽  
Camilla Fröhlich ◽  
Bent Nørgaard Pedersen ◽  
Michael Christiansen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Serum Marker ◽  
Maternal Serum

The proform of eosinophil major basic protein: a new maternal serum marker for Down syndrome

1999 ◽  
Vol 19 (10) ◽  
pp. 905-910 ◽  
Author(s):  
Michael Christiansen ◽  
Claus Oxvig ◽  
Jill M. Wagner ◽  
Qiu-Ping Qin ◽  
Tri H. Nguyen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Basic Protein ◽  
Protein A ◽  
Serum Marker ◽  
Maternal Serum ◽  
Major Basic Protein ◽  
Eosinophil Major Basic Protein

scholarly journals The Effect of Down Syndrome Biochemical Markers on Predicting Severity of Preeclampsia

2020 ◽  
Author(s):  
AYSE OZBAN
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tests ◽  
Second Trimester ◽  
Study Results ◽  
Second Trimester Screening ◽  
Trimester Screening

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

scholarly journals Impact of Ductus Venosus Assessment in Screening Down Syndrome Protocols: An Improved Strategy in a Fetal Medicine Unit

2009 ◽  
Vol 3 (2) ◽  
pp. 10-17 ◽  
Author(s):  
Mónica Echevarria ◽  
Carmen Comas ◽  
M Angeles Rodríguez ◽  
Joan Nicolau ◽  
Bernat Serra ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Serum Biochemistry ◽  
Screening Strategy ◽  
Maternal Serum ◽  
Ductus Venosus ◽  
Early Evaluation ◽  
Invasive Test ◽  
Screening Efficiency

ABSTRACT Objective To estimate the improvement in screening efficiency when ductus venosus (DV) Doppler studies are added to existing Down syndrome (DS) screening protocols. Methods First-trimester combined screening for trisomy 21 was prospectively carried out, from October 2003 to March 2008, in 8842 consecutive singleton pregnancies attended in our tertiary reference center. The nuchal translucency (NT) and the pulsatility index for veins for DV were calculated. The maternal serum biochemistry was measured using the Kryptor analyzer, at the same time of the scan (one step strategy) or before it (two step strategy). The detection rate (DR) and false-positive rates for standard screening strategy (maternal age, NT and biochemistry) and the same strategy but including DV assessment were calculated. Results Successful DV assessment was possible in the 95.3% of cases, representing a total of 8426 cases. Down syndrome was identified in 34 pregnancies (prevalence of DS 1:250). For a fixed screen positive rate of 5%, the addition of the DV assessment improves the DR from 85 to 94% and, for a fixed DR of 85%, it reduces the number of unnecessary invasive tests from 3.7 to 3.2%. Conclusion Early evaluation of DV can be introduced to standard DS screening strategies in experienced centers as a first level test to reduce invasive test rate derived from the existing protocols.

Strong impact of ethnicity on effectiveness of the first trimester maternal serum screen of fetal Down syndrome

2017 ◽  
Vol 31 (21) ◽  
pp. 2847-2851 ◽  
Author(s):  
Thitikarn Lerthiranwong ◽  
Chanane Wanapirak ◽  
Supatra Sirichotiyakul ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupundit ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Maternal Serum ◽  
Strong Impact

Screening for Down syndrome in the first trimester

1995 ◽  
Vol 7 (6) ◽  
pp. 1413 ◽  
Author(s):  
KJ Powell ◽  
JG Grudzinskas
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Published Data ◽  
Maternal Serum Screening ◽  
Ultrasound Findings ◽  
Serum Screening ◽  
Associated Proteins ◽  
Trimester Screening

Second-trimester maternal serum screening for Down syndrome is now well established, and permits detection of up to 70% of cases. The disadvantage of this sort of screening is that the timing of maternal blood sampling is relatively late (after 15 weeks). There is an accumulating body of evidence to suggest that in the first trimester concentrations of a number of pregnancy-associated proteins and hormones differ in chromosomally normal and abnormal pregnancies. A first-trimester maternal serum screening test for Down syndrome may therefore be possible. In addition, new methods of screening have recently been described based on ultrasound findings at 11 to 13 weeks of gestation. This review article presents a discussion of published data on the feasibility of first-trimester screening for Down syndrome.

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