The influence of faith and religion and the role of religious and community leaders in prenatal decisions for sickle cell disorders and thalassaemia major

2006 ◽  
Vol 26 (9) ◽  
pp. 801-809 ◽  
Author(s):  
Shenaz Ahmed ◽  
Karl Atkin ◽  
Jenny Hewison ◽  
Josephine Green
Keyword(s):  
Sickle Cell ◽  
Community Leaders ◽  
Thalassaemia Major ◽  
Sickle Cell Disorders

scholarly journals Improving Screening Programmes for Sickle Cell Disorders and Other Haemoglobinopathies in Europe: The Role of Patient Organisations

2019 ◽  
Vol 5 (1) ◽  
pp. 12
Author(s):  
John James ◽  
Elizabeth Dormandy
Keyword(s):  
National Health Service ◽  
Sickle Cell ◽  
Screening Programme ◽  
Added Value ◽  
Unique Contribution ◽  
Discussion Paper ◽  
Patient Organisations ◽  
Sickle Cell Disorders ◽  
Cell Disorder

This discussion paper has been written to show the unique contribution and added value that Patient Organisations can give to the development and improvement of newborn screening programmes for sickle cell disorder (SCD) and other haemoglobinopathies in Europe. As an example, the action of the Sickle Cell Society (SCS) in partnership with statutory organisations in the U.K., such as the National Health Service (NHS) Sickle Cell and Thalassaemia Screening Programme (NHS SCT SP), will be described.

The orientation of sickle hemoglobin fibers within fascicles

1988 ◽  
Vol 46 ◽  
pp. 400-401
Author(s):  
Christopher A. Miller ◽  
Bridget Carragher ◽  
William A. McDade ◽  
Robert Josephs
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Relative Orientation ◽  
Unit Cell ◽  
Red Cell ◽  
High Ph ◽  
Sickle Hemoglobin ◽  
Polar Crystal ◽  
Helical Configuration

Highly ordered bundles of deoxyhemoglobin S (HbS) fibers, termed fascicles, are intermediates in the high pH crystallization pathway of HbS. These fibers consist of 7 Wishner-Love double strands in a helical configuration. Since each double strand has a polarity, the odd number of double strands in the fiber imparts a net polarity to the structure. HbS crystals have a unit cell containing two double strands, one of each polarity, resulting in a net polarity of zero. Therefore a rearrangement of the double strands must occur to form a non-polar crystal from the polar fibers. To determine the role of fascicles as an intermediate in the crystallization pathway it is important to understand the relative orientation of fibers within fascicles. Furthermore, an understanding of fascicle structure may have implications for the design of potential sickling inhibitors, since it is bundles of fibers which cause the red cell distortion responsible for the vaso-occlusive complications characteristic of sickle cell anemia.

Volunteer Management Reference for Local VCE Master Gardener Coordinators

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 503a-503
Author(s):  
Sheri T. Dorn ◽  
Paula Diane Relf
Keyword(s):  
Educational Program ◽  
Program Planning ◽  
Community Leaders ◽  
Volunteer Management ◽  
Educational Programming ◽  
Job Descriptions ◽  
Master Gardener ◽  
Volunteer Program ◽  
Reference Guide

Virginia Cooperative Extension's (VCE) Master Gardener volunteer program is available in 72 unit offices. The unit programs are managed by MG coordinators who currently include 10 locally funded agents, eight locally funded technicians, and 28 volunteers. The VCE Master Gardener Coordinator Manual, a 12-unit resource book, was developed cooperatively with teams of MGs, coordinators, and agents to enhance coordinators' skills for managing the local VCE MG program. The manual includes chapters on VCE MG components such as risk management; job descriptions; recruitment and screening; and volunteer review, recognition, and retention. Additional resources within the manual include a synopsis of educational program planning, implementation, and evaluation, as well as a copy of the current VCE Master Gardener Program Policies and the volunteer section of the Virginia Master Gardener Handbook, which serves as program orientation for new or prospective trainees. The VCE Master Gardener Coordinator Manual is the basis of three local MG coordinator training sessions in 1998. Additional resources available to coordinators for enhancing the local MG program include a MG newsletter focused on the role of Master Gardeners as community leaders and educators; program policies and guidelines for the management of MG training and operation; VCE publication 426-699 Welcome to Virginia Master Gardenering! Guide to Educational Programming and Resource and Reference Guide; and the VCE Master Gardener Internet website at http://www.ext.vt.edu/vce/specialty/envirohort/mastergard/master.html.

Fluorescence spectroscopy as a novel technique for premarital screening of sickle cell disorders

2021 ◽  
pp. 102276
Author(s):  
Sandhanasamy Devanesan ◽  
Mohamad S. AlSalhi ◽  
Vadivel Masilamani ◽  
Fathima AlQatahny ◽  
Aruliah Rajasekar ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Sickle Cell ◽  
Novel Technique ◽  
Premarital Screening ◽  
Sickle Cell Disorders

scholarly journals Antiphospholipid Antibodies in Sickle Cell Disease: A Systematic Review and Exploratory Meta-Analysis

2021 ◽  
Vol 27 ◽  
pp. 107602962110029
Author(s):  
Mira Merashli ◽  
Alessia Arcaro ◽  
Maria Graf ◽  
Matilde Caruso ◽  
Paul R. J. Ames ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Antiphospholipid Antibodies ◽  
Meta Analysis ◽  
Age Groups ◽  
Anticardiolipin Antibodies ◽  
Cell Disease ◽  
Pooled Prevalence ◽  
The Relationship

The relationship between antiphospholipid antibodies (aPL) and sickle cell disease (SCD) has never been systematically addressed. Our aim was to evaluate potential links between SCD and aPL in all age groups. EMBASE/PubMed was screened from inception to May 2020 and Peto odds ratios for rare events were calculated. The pooled prevalence (PP) of IgG anticardiolipin antibodies (aCL) was higher in individuals with SCD than in controls (27.9% vs 8.7%, P < 0.0001), that of IgM aCL was similar in the two groups (2.9% vs 2.7%); only individuals with SCD were positive for lupus anticoagulant (LA) (7.7% vs 0%, P < 0.0001). The PP of leg ulcers was similar between aPL positive and negative individuals (44% vs 53%) and between patients in acute crisis and stable patients (5.6% vs 7.3%). Reporting of aPL as a binary outcome and not as a titer precluded further interpretation. The results indicate that a prospective case-control study with serial measurements of a panel of aPL in SCD patients might be warranted, in order to understand further the possible pathogenic role of aPL in SCD.

scholarly journals Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 296
Author(s):  
Rosa Vona ◽  
Nadia Maria Sposi ◽  
Lorenza Mattia ◽  
Lucrezia Gambardella ◽  
Elisabetta Straface ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Globin Gene ◽  
Organ Damage ◽  
Cell Disease ◽  
Vessel Occlusion ◽  
Antioxidant Agents ◽  
Oxidant Status

Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb), which affects approximately a million people worldwide. It is characterized by a single nucleotide substitution in the β-globin gene, leading to the production of abnormal sickle hemoglobin (HbS) with multi-system consequences. HbS polymerization is the primary event in SCD. Repeated polymerization and depolymerization of Hb causes oxidative stress that plays a key role in the pathophysiology of hemolysis, vessel occlusion and the following organ damage in sickle cell patients. For this reason, reactive oxidizing species and the (end)-products of their oxidative reactions have been proposed as markers of both tissue pro-oxidant status and disease severity. Although more studies are needed to clarify their role, antioxidant agents have been shown to be effective in reducing pathological consequences of the disease by preventing oxidative damage in SCD, i.e., by decreasing the oxidant formation or repairing the induced damage. An improved understanding of oxidative stress will lead to targeted antioxidant therapies that should prevent or delay the development of organ complications in this patient population.

Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell Disease

Hematology ◽  
2007 ◽  
Vol 2007 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Marilyn J. Telen
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Adhesion Molecules ◽  
Sickle Cell ◽  
Vascular Endothelium ◽  
Blood Cells ◽  
Cell Disease ◽  
Adhesive Interactions ◽  
Lines Of Evidence

AbstractA number of lines of evidence now support the hypothesis that vaso-occlusion and several of the sequelae of sickle cell disease (SCD) arise, at least in part, from adhesive interactions of sickle red blood cells, leukocytes, and the endothelium. Both experimental and genetic evidence provide support for the importance of these interactions. It is likely that future therapies for SCD might target one or more of these interactions.

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