Prenatal diagnosis of a long QT syndrome by fetal magnetocardiography in an unshielded bedside environment

2005 ◽  
Vol 25 (8) ◽  
pp. 704-708 ◽  
Author(s):  
Uwe Schneider ◽  
Jens Haueisen ◽  
Markus Loeff ◽  
Nikolai Bondarenko ◽  
Ekkehard Schleussner
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Fetal Magnetocardiography ◽  
Qt Syndrome

scholarly journals Prenatal diagnosis of long QT syndrome using fetal magnetocardiography

1999 ◽  
Vol 19 (7) ◽  
pp. 677-680 ◽  
Author(s):  
Hiromi Hamada ◽  
Hitoshi Horigome ◽  
Mitsuhiro Asaka ◽  
Sadahiko Shigemitsu ◽  
Toshio Mitsui ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Fetal Magnetocardiography ◽  
Qt Syndrome

scholarly journals Complex and Novel Arrhythmias Precede Stillbirth in Fetuses With De Novo Long QT Syndrome

2020 ◽  
Vol 13 (5) ◽  
Author(s):  
Sarah Strand ◽  
Janette F. Strasburger ◽  
Bettina F. Cuneo ◽  
Ronald T. Wakai
Keyword(s):  
Atrioventricular Block ◽  
Long Qt Syndrome ◽  
De Novo ◽  
Perinatal Death ◽  
Torsade De Pointes ◽  
Fetal Loss ◽  
Long Qt ◽  
Premature Ventricular Contractions ◽  
Fetal Magnetocardiography ◽  
Qt Syndrome

Background: Long QT syndrome (LQTS) is a leading cause of sudden cardiac death in early life and has been implicated in ≈10% of sudden infant deaths and unexplained stillbirths. The purpose of our study was to use fetal magnetocardiography to characterize the electrophysiology and rhythm phenotypes of fetuses with de novo and inherited LQTS variants and identify risk factors for sudden death before birth. Methods: We reviewed the fetal magnetocardiography database from the University of Wisconsin Biomagnetism Laboratory for fetuses with confirmed LQTS. We assessed waveform intervals, heart rate, and rhythm, including the signature LQTS rhythms: functional 2° atrioventricular block, T-wave alternans, and torsade de pointes (TdP). Results: Thirty-nine fetuses had pathogenic variants in LQTS genes: 27 carried the family variant, 11 had de novo variants, and 1 was indeterminate. De novo variants, especially de novo SCN5A variants, were strongly associated with a severe rhythm phenotype and perinatal death: 9 (82%) showed signature LQTS rhythms, 6 (55%) showed TdP, 5 (45%) were stillborn, and 1 (9%) died in infancy. Those that died exhibited novel fetal rhythms, including atrioventricular block with 3:1 conduction ratio, QRS alternans in 2:1 atrioventricular block, long-cycle length TdP, and slow monomorphic ventricular tachycardia. Premature ventricular contractions were also strongly associated with TdP and perinatal death. Fetuses with familial variants showed a lower incidence of signature LQTS rhythm (6/27=22%), including TdP (3/27=11%). All were live born. Conclusions: The malignancy of de novo LQTS variants was remarkably high and demonstrate that these mutations are a significant cause of stillbirth. Their ability to manifest rhythms not known to be associated with LQTS increases the difficulty of echocardiographic diagnosis and decreases the likelihood that a resultant fetal loss is attributed to LQTS. Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT03047161.

Prenatal diagnosis and treatment of fetal long QT syndrome: a case report

2002 ◽  
Vol 22 (13) ◽  
pp. 1209-1212 ◽  
Author(s):  
Ing-Kuang Chang ◽  
Ming-Kwang Shyu ◽  
Chien-Nan Lee ◽  
Miau-Ling Kau ◽  
Yu-Hsueh Ko ◽  
...  
Keyword(s):  
Case Report ◽  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Diagnosis And Treatment ◽  
Long Qt ◽  
Qt Syndrome

Prenatal diagnosis and In Utero treatment of Torsades de Pointes associated with congenital long QT syndrome

2003 ◽  
Vol 91 (11) ◽  
pp. 1395-1398 ◽  
Author(s):  
Bettina F. Cuneo ◽  
Marc Ovadia ◽  
Janette F. Strasburger ◽  
Hui Zhao ◽  
Tom Petropulos ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Torsades De Pointes ◽  
In Utero ◽  
Long Qt ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

Prenatal diagnosis of long QT syndrome by non-invasive fetal electrocardiography

2009 ◽  
Vol 35 (3) ◽  
pp. 555-561 ◽  
Author(s):  
Yoshinobu Fujimoto ◽  
Tadashi Matsumoto ◽  
Nobuhisa Honda ◽  
Ryuichiro Tojo ◽  
Masataka Furuya ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Non Invasive ◽  
Qt Syndrome ◽  
Fetal Electrocardiography

Prenatal diagnosis of long QT syndrome: implications for delivery room and neonatal management

2012 ◽  
Vol 23 (1) ◽  
pp. 141-145 ◽  
Author(s):  
E. Anne Greene ◽  
Charles I. Berul ◽  
Mary T. Donofrio
Keyword(s):  
Prenatal Diagnosis ◽  
Atrioventricular Block ◽  
Long Qt Syndrome ◽  
Postnatal Care ◽  
Ventricular Arrhythmias ◽  
Torsade De Pointes ◽  
Successful Outcome ◽  
Long Qt ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

AbstractThis case describes the prenatal diagnosis and integrated peripartum management of a foetus with 2:1 atrioventricular block and torsade de pointes due to congenital long QT syndrome. The unique issues related to the detection of intrauterine conduction abnormalities and ventricular arrhythmias, along with the immediate postnatal care, have been described as an interesting teaching case with successful outcome.

scholarly journals Erratum to: Prenatal Diagnosis and Management of Fetal Long QT Syndrome

2009 ◽  
Vol 30 (8) ◽  
pp. 1197-1197
Author(s):  
Viktor Tomek ◽  
Jan Skovranek ◽  
Roman A. Gebauer
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Diagnosis And Management ◽  
Qt Syndrome

Prenatal Diagnosis and Management of Fetal Long QT Syndrome

2008 ◽  
Vol 30 (2) ◽  
pp. 194-196 ◽  
Author(s):  
Viktor Tomek ◽  
Jan Skovranek ◽  
Roman A. Gebauer
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Diagnosis And Management ◽  
Qt Syndrome
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