Survey on the future organisation of first-trimester ultrasound screening in Flanders, Belgium

2005 ◽  
Vol 25 (6) ◽  
pp. 518-519 ◽  
Author(s):  
Wilfried Gyselaers ◽  
Luc De Catte ◽  
Ingrid Witters ◽  
Eric de Jonge ◽  
Willem Ombelet ◽  
...  
Keyword(s):  
First Trimester ◽  
Ultrasound Screening ◽  
The Future ◽  
First Trimester Ultrasound

First-trimester ultrasound screening for chromosomal defects

1996 ◽  
Vol 7 (3) ◽  
pp. 216-226 ◽  
Author(s):  
R. J. M. Snijders ◽  
S. Johnson ◽  
N. J. Sebire ◽  
P. L. Noble ◽  
K. H. Nicolaides
Keyword(s):  
First Trimester ◽  
Ultrasound Screening ◽  
Chromosomal Defects ◽  
First Trimester Ultrasound

The Value of Detailed First-Trimester Ultrasound Anomaly Scan for the Detection of Chromosomal Abnormalities

2018 ◽  
Vol 40 (06) ◽  
pp. 743-748
Author(s):  
Ismail Tekesin
Keyword(s):  
Turner Syndrome ◽  
Trisomy 21 ◽  
Detection Rate ◽  
First Trimester ◽  
Trisomy 18 ◽  
Trisomy 13 ◽  
Ductus Venosus ◽  
Ultrasound Screening ◽  
Crown Rump Length ◽  
First Trimester Ultrasound

Abstract Purpose To evaluate the performance of first-trimester ultrasound screening involving a detailed anomaly scan for the detection of trisomy 18, trisomy 13, triploidy, Turner syndrome and trisomy 21. Methods Data of pregnant women who underwent aneuploidy screening at 11–13 weeks of gestation was retrospectively analyzed. Crown-rump length (CRL), fetal nuchal translucency thickness (NT) and nasal bone (NB) anatomy, blood flow across the tricuspid valve (TV) and through the ductus venosus (DV) were assessed. Furthermore, a detailed scan for fetal anatomical anomalies (FA) was carried out. Performance of these markers was assessed by logistic regression and ROC analyses for different screening models. Results 4005 fetuses were analyzed. 3856 were euploid, 149 aneuploid (trisomy 18: 40; trisomy 13: 14; triploidy: 3; Turner syndrome: 17; trisomy 21: 75 cases). 70–100 % of the fetuses with trisomy 18 and 13, triploidy and Turner syndrome but only 34.7 % with trisomy 21 had at least one fetal defect. Considering all aneuploidies, the detection rate (DR) for screening based on MA+NT+NB+TV+DV was 90.6 % and improved to 96.0 % if an FA was added (fixed false-positive rate: 3 %). If screening was based on MA+NT+FA, the detection rate for all aneuploidies was 85.2 %. However, the DR for trisomy 18, trisomy 13, triploidy and Turner syndrome (excluding trisomy 21) was 94.6 %, indicating the high diagnostic value of an anomaly scan for these aneuploidies. Conclusion Incorporation of a detailed fetal anomaly scan (FA) into first-trimester screening algorithms can improve the detection rates for trisomy 18 and 13, triploidy and Turner syndrome.

What about Informed Consent in First-Trimester Ultrasound Screening for Down Syndrome?

2008 ◽  
Vol 23 (3) ◽  
pp. 173-184 ◽  
Author(s):  
Romain Favre ◽  
Grégoire Moutel ◽  
Nathalie Duchange ◽  
Christophe Vayssière ◽  
Monique Kohler ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Informed Consent ◽  
First Trimester ◽  
Ultrasound Screening ◽  
First Trimester Ultrasound
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