Selective INEPT spectroscopy–-A powerful tool for the spectral assignment and structure elucidation of natural products

1991 ◽  
Vol 2 (2) ◽  
pp. 49-59 ◽  
Author(s):  
Geoffrey A. Cordell
Keyword(s):  
Natural Products ◽  
Structure Elucidation ◽  
Spectral Assignment

scholarly journals Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1094
Author(s):  
Melissa M. Cadelis ◽  
Soeren Geese ◽  
Benedict B. Uy ◽  
Daniel R. Mulholland ◽  
Shara J. van de Pas ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Natural Products ◽  
Structure Elucidation ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Spectroscopic Methods ◽  
Methicillin Resistant ◽  
Bioassay Guided Fractionation ◽  
Antimicrobial Metabolites

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.

scholarly journals Isolation of a Novel Polyketide from Neodidymelliopsis sp.

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3235
Author(s):  
Melissa M. Cadelis ◽  
Hugo Gordon ◽  
Alex Grey ◽  
Soeren Geese ◽  
Daniel R. Mulholland ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Ambient Temperature ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Fungal Pathogens ◽  
Spectroscopic Techniques ◽  
Bioactive Natural Products

Fungi have become an invaluable source of bioactive natural products, with more than 5 million species of fungi spanning the globe. Fractionation of crude extract of Neodidymelliopsis sp., led to the isolation of a novel polyketide, (2Z)-cillifuranone (1) and five previously reported natural products, (2E)-cillifuranone (2), taiwapyrone (3), xylariolide D (4), pachybasin (5), and N-(5-hydroxypentyl)acetamide (6). It was discovered that (2Z)-cillifuranone (1) was particularly sensitive to ambient temperature and light resulting in isomerisation to (2E)-cillifuranone (2). Structure elucidation of all the natural products were conducted by NMR spectroscopic techniques. The antimicrobial activity of 2, 3, and 5 were evaluated against a variety of bacterial and fungal pathogens. A sodium [1-13C] acetate labelling study was conducted on Neodidymelliopsis sp. and confirmed that pachybasin is biosynthesised through the acetate polyketide pathway.

ChemInform Abstract: Principles and Applications of Modern 2D NMR Techniques in Structure Elucidation of Complex Natural Products

ChemInform ◽  
2010 ◽  
Vol 23 (42) ◽  
pp. no-no
Author(s):  
ATTA-UR-RAHMAN ATTA-UR-RAHMAN ◽  
M. I. CHOUDHARY ◽  
A. PERVIN
Keyword(s):  
Natural Products ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Nmr Techniques

scholarly journals The myxocoumarins A and B fromStigmatella aurantiacastrain MYX-030

2013 ◽  
Vol 9 ◽  
pp. 2579-2585 ◽  
Author(s):  
Tobias A M Gulder ◽  
Snežana Neff ◽  
Traugott Schüz ◽  
Tammo Winkler ◽  
René Gees ◽  
...  
Keyword(s):  
Natural Products ◽  
Structure Elucidation ◽  
Biological Evaluation ◽  
Biologically Active ◽  
Antifungal Properties ◽  
Structural Framework ◽  
Stigmatella Aurantiaca ◽  
Promising Source ◽  
Active Natural

The myxobacterial strainStigmatella aurantiacaMYX-030 was selected as promising source for the discovery of new biologically active natural products by our screening methodology. The isolation, structure elucidation and initial biological evaluation of the myxocoumarins derived from this strain are described in this work. These compounds comprise an unusual structural framework and exhibit remarkable antifungal properties.

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