Coaxial electrospinning process toward optimal nanoparticle dispersion in polymeric matrix

2021 ◽  
Author(s):  
Francisco Sebastian Navarro Oliva ◽  
Léo Picart ◽  
Christopher Y. Leon‐Valdivieso ◽  
Ahmed Benalla ◽  
Luc Lenglet ◽  
...  
Keyword(s):  
Electrospinning Process ◽  
Polymeric Matrix ◽  
Coaxial Electrospinning ◽  
Nanoparticle Dispersion

Borneol-Shellac Nanofiber Membranes Fabricated Using a Modified Coaxial Electrospinning

2014 ◽  
Vol 1058 ◽  
pp. 78-82 ◽  
Author(s):  
Deng Guang Yu ◽  
Ying Xu ◽  
Song Liu ◽  
Yu Hai Wang ◽  
Xiao Duan ◽  
...  
Keyword(s):  
Physical Stability ◽  
Amorphous State ◽  
Average Diameter ◽  
Electrospinning Process ◽  
Flow Rate Ratio ◽  
Coaxial Electrospinning ◽  
High Quality ◽  
Pure Ethanol ◽  
Sheath Fluid ◽  
Nanofiber Membranes

A modified coaxial electrospinning process is developed for producing medicated nanofiber membranes of shellac. With pure ethanol as a sheath fluid, high quality borneol-loaded shellac nanofibers have been successfully fabricated using the modified coaxial process. Electron scanning microscopic observations demonstrated that the nanofibers had better quality than those fabricated using a single fluid electrospinning in terms of nanofiber diameters and their distributions. The former had an average diameter of 570 ± 80 nm under a sheath-to-core flow rate ratio of 0.25, whereas the later was 940 ± 230 nm. X-ray diffraction results verified that borneol existed in the shellac matrix in an amorphous state. The medicated nanofiber membranes could significantly improved the physical stability of borneol due to the favorable hydrogen bonding between the drug and the polymer matrix, as demonstrated by the weight loss experiments. The modified coaxial electrospinning process described here expands the capability of electrospinning process in generating high quality functional membranes.

Design of Coaxial Needleless Electrospinning Electrode with Respect to the Distribution of Electric Field

2014 ◽  
Vol 693 ◽  
pp. 394-399 ◽  
Author(s):  
Lucie Vysloužilová ◽  
Jan Valtera ◽  
Karel Pejchar ◽  
Jaroslav Beran ◽  
David Lukáš
Keyword(s):  
Free Surface ◽  
Electric Field ◽  
Electrostatic Field ◽  
Electric Energy ◽  
Electrospinning Process ◽  
Coaxial Electrospinning ◽  
Core Shell ◽  
Process Stability ◽  
Field Simulation ◽  
Sharp Edges

The paper is focused on the design of the electrode for needleless coaxial electrospinning. This method allows to produce core/shell nanofibers from the free surface of a polymeric two-layer. The geometry of the designed model of electrode was analyzed using the software Autodesk Simulation Multiphysics. The results of electrostatic field simulation indicate the sharp edges of the electrode as the source of high electric intensity. These sharp edges lead to the loss of the electric energy during the electrospinning process. Based on that, the new cylindrical geometry of the electrode was developed. The results of carried out experiments clearly demonstrate the enhancement of the electrospinning process stability.

Electrospun Ketoprofen Sustained Release Nanofibers Prepared Using Coaxial Electrospinning

2013 ◽  
Vol 395-396 ◽  
pp. 138-143 ◽  
Author(s):  
Deng Guang Yu ◽  
Min Hao Hu ◽  
Wen Zhou ◽  
Bi Yu Chen ◽  
Xia Wang
Keyword(s):  
Sustained Release ◽  
Diffusion Mechanism ◽  
Electrospinning Process ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Coaxial Electrospinning ◽  
Electron Microscopic ◽  
Sheath Fluid ◽  
Release Drug

The present study investigates the preparation of sustained release drug-loaded nanofibers using a modified coaxial electrospinning process where only solvent is exploited as sheath fluid. Drug-loaded ethyl cellulose (EC) nanofibers are successfully generated smoothly and continuously without any clogging through the coaxial process, in which ethanol is used as sheath fluid and EC and ketoprofen (KET) are taken as the filament-forming matrix and active pharmaceutical ingredient, respectively. Field-emission scanning electron microscopic observations demonstrated that the nanofibers diameter can be manipulated through the sheath fluid flow rate. The composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that KET in the nanofibers has a fine sustained release profile via a typical Fickian diffusion mechanism. The modified coaxial electrospinning with solvent as sheath fluid can be a useful tool for developing novel sustained release drug delivery nanofibers.

scholarly journals Triple-Component Drug-Loaded Nanocomposites Prepared Using a Modified Coaxial Electrospinning

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Wei Qian ◽  
Deng-Guang Yu ◽  
Ying Li ◽  
Xiao-Yan Li ◽  
Yao-Zu Liao ◽  
...  
Keyword(s):  
Flow Rate ◽  
Average Diameter ◽  
Electrospinning Process ◽  
Flow Rate Ratio ◽  
Uniform Structure ◽  
Coaxial Electrospinning ◽  
Sustained Drug Release ◽  
Sheath Fluid ◽  
Transdermal Drug Delivery Systems

Triple-component nanocomposites for improved sustained drug release profiles are successfully fabricated through a modified coaxial electrospinning process, in which only organic solvent N,N-dimethylacetamide was used as sheath fluid. Using polyacrylonitrile (PAN) as filament-forming matrix, ibuprofen (IBU) as functional ingredient, and polyvinylpyrrolidone (PVP) as the additional component, the IBU/PVP/PAN triple-component nanocomposites had uniform structure and an average diameter of620±120 nm and650±120 nm when the contents of PVP in the nanofibers were 10.5% and 22.7%, respectively. The optimal sheath-to-core flow rate ratio was 0.11 under a total sheath and core fluid flow rate of 1.0 mL/h. Compared with the IBU/PAN composite nanofibers, the triple-component composites could release 92.1% and 97.8% of the contained IBU, significantly larger than a value of 73.4% from the former. The inclusion of PVP in the IBU/PAN could effectively avoid the entrapment of IBU in the insoluble PAN molecules, facilitating thein vitrorelease of IBU. The modified coaxial process and the resulted multiple component nanocomposites would provide new way for developing novel drug sustained materials and transdermal drug delivery systems.

A novel strategy to directly fabricate flexible hollow nanofibers with tunable luminescence–electricity–magnetism trifunctionality using one-pot electrospinning

2015 ◽  
Vol 17 (35) ◽  
pp. 22977-22984 ◽  
Author(s):  
Yawen Liu ◽  
Qianli Ma ◽  
Xiangting Dong ◽  
Wensheng Yu ◽  
Jinxian Wang ◽  
...  
Keyword(s):  
Electrospinning Process ◽  
Coaxial Electrospinning ◽  
Hollow Nanofibers ◽  
One Pot ◽  
Novel Strategy ◽  
First Time

Novel photoluminescent–electrical–magnetic trifunctional flexible Eu(BA)3phen/PANI/Fe3O4/PVP hollow nanofibers were constructed using a one-pot coaxial electrospinning process for the first time.

Fabrication and characterization of continuous silver nanofiber/polyvinylpyrrolidone (AgNF/PVP) core–shell nanofibers using the coaxial electrospinning process

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54162-54168 ◽  
Author(s):  
Molla Bahiru Gebeyehu ◽  
Yu-Hao Chang ◽  
Angaw Kelemework Abay ◽  
Shao-Yen Chang ◽  
Jiunn-Yih Lee ◽  
...  
Keyword(s):  
Electrospinning Process ◽  
Coaxial Electrospinning ◽  
Core Shell ◽  
Electrospinning Method ◽  
Fabrication And Characterization

Core–shell silver nanofiber/polyvinylpyrrolidone (AgNF/PVP) nanofibers have been successfully fabricated via an efficient coaxial-spinneret electrospinning method with a vertical configuration using PVP and AgNO3 as precursor solutions.

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