Controlling the degradation of dicalcium phosphate/calcium sulfate/poly(amino acid) biocomposites for bone regeneration

2016 ◽  
Vol 39 ◽  
pp. E122-E131 ◽  
Author(s):  
Peng Wang ◽  
Pengzheng Liu ◽  
Fan Xu ◽  
Xiaoxia Fan ◽  
Huipin Yuan ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bone Regeneration ◽  
Calcium Sulfate ◽  
Dicalcium Phosphate

scholarly journals In vitroandin vivocharacterization of strontium-containing calcium sulfate/poly(amino acid) composite as a novel bioactive graft for bone regeneration

RSC Advances ◽  
2017 ◽  
Vol 7 (86) ◽  
pp. 54306-54312 ◽  
Author(s):  
Wu Jun ◽  
Wang Peng ◽  
Jiang Dianming ◽  
Li Hong ◽  
Luo Cong ◽  
...  
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Bone Regeneration ◽  
Calcium Sulfate ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects

Doped strontium enhanced the biological activity of CS/PAA composites for repairing large bone defects.

Effects of the surface modification of poly(amino acid)/hydroxyapatite/calcium sulfate biocomposites on the adhesion and proliferation of osteoblast-like cells

2015 ◽  
Vol 132 (33) ◽  
pp. n/a-n/a ◽  
Author(s):  
Xiaoxia Fan ◽  
Haohao Ren ◽  
Pengzheng Liu ◽  
Peng Wang ◽  
Hong Li ◽  
...  
Keyword(s):  
Surface Modification ◽  
Amino Acid ◽  
Calcium Sulfate

In vitro and in vivo biological characterizations of a new poly(amino acids)/calcium sulfate composite material for bone regeneration

2012 ◽  
Vol 48 (5) ◽  
pp. 2022-2029 ◽  
Author(s):  
Zeng Hui Zhao ◽  
Zheng Xue Quan ◽  
Dian Ming Jiang ◽  
Hong Li ◽  
Liang Guo ◽  
...  
Keyword(s):  
Amino Acids ◽  
Composite Material ◽  
Bone Regeneration ◽  
Calcium Sulfate

scholarly journals The Development of Gelatin/Hyaluronate Copolymer Mixed with Calcium Sulfate, Hydroxyapatite, and Stromal-Cell-Derived Factor-1 for Bone Regeneration Enhancement

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1454 ◽  
Author(s):  
Yun-Liang Chang ◽  
Chia-Ying Hsieh ◽  
Chao-Yuan Yeh ◽  
Feng-Huei Lin
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Calcium Sulfate ◽  
Stromal Cell ◽  
Femoral Condyle ◽  
Bone Defects ◽  
Blood Analysis ◽  
Control Group ◽  
Defect Model ◽  
Stromal Cell Derived Factor

In clinical practice, bone defects still remain a challenge. In recent years, apart from the osteoconductivity that most bone void fillers already provide, osteoinductivity has also been emphasized to promote bone healing. Stromal-cell-derived factor-1 (SDF-1) has been shown to have the ability to recruit mesenchymal stem cells (MSCs), which play an important role in the bone regeneration process. In this study, we developed a gelatin–hyaluronate (Gel-HA) copolymer mixed with calcium sulfate (CS), hydroxyapatite (HAP), and SDF-1 in order to enhance bone regeneration in a bone defect model. The composites were tested in vitro for biocompatibility and their ability to recruit MSCs after material characterization. For the in vivo test, a rat femoral condyle bone defect model was used. Micro computed tomography (Micro-CT), two-photon excitation microscopy, and histology analysis were performed to assess bone regeneration. As expected, enhanced bone regeneration was well observed in the group filled with Gel-HA/CS/HAP/SDF-1 composites compared with the control group in our animal model. Furthermore, detailed blood analysis of rats showed no obvious systemic toxicity or side effects after material implantation. In conclusion, the Gel-HA/CS/HAP/SDF-1 composite may be a safe and applicable material to enhance bone regeneration in bone defects.

scholarly journals Highly porous polycaprolactone scaffolds doped with calcium silicate and dicalcium phosphate dihydrate designed for bone regeneration

2019 ◽  
Vol 102 ◽  
pp. 341-361 ◽  
Author(s):  
Maria Giovanna Gandolfi ◽  
Fausto Zamparini ◽  
Micaela Degli Esposti ◽  
Federica Chiellini ◽  
Fabio Fava ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Calcium Silicate ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Highly Porous
Sign in / Sign up

Export Citation Format

Share Document