Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

2015 ◽  
Vol 38 ◽  
pp. E74-E80 ◽  
Author(s):  
Jhimli P. Guin ◽  
C.V. Chaudhari ◽  
K.A. Dubey ◽  
Y.K. Bhardwaj ◽  
L. Varshney
Keyword(s):  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Carboxymethyl Cellulose ◽  
Controlled Drug Release ◽  
Cellulose Nanocomposites

The Synthesis and Characterization of PVA-Ketoprofen Cryogel, Biomaterial with Extended Drug Release Properties for Cartilage Replacement

2014 ◽  
Vol 216 ◽  
pp. 205-209
Author(s):  
Monica Cretan Stamate ◽  
Ciprian Stamate
Keyword(s):  
Articular Cartilage ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Water Solubility ◽  
Physicochemical Characterization ◽  
Gravimetric Method ◽  
Controlled Drug Release ◽  
High Wear Resistance ◽  
Mechanical Resistance ◽  
Swelling Properties

The present paper aims to study the possibility to modify the properties of polyvinyl alcohol (pva) cryogels prepared in the presence of ketoprofen in order to replace the damaged articular cartilage. Articular cartilage is the most important part of articulation characterized by very low friction, high wear resistance, and poor regenerative qualities. Polyvinyl alcohol is a non-expensive polymer, versatile and adaptable to various needs, with exceptional properties such as water solubility, biocompatibility, non-toxicity and with capability to form hydrogels by chemical or physical methods. The aims of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties of pva cryogels for cartilage replacement and the introduction of new concept in medication by creating the cryogel like a controlled drug release system. The morphology of the cryogels, the interaction between the pva macromolecular chains and medicament has been studied by Scanning Electronic Microscopy. The gels swelling in physiologic ser have been monitored by gravimetric method in order to evidence the hydrophilic properties. The mechanical properties of the cryogels have been investigated by dynamic mechanical measurements. In conclusion, the biomaterial obtained provides good swelling properties, mechanical resistance and it is ideal for extended drug release implantable systems.

Light-responsive arylazopyrazole-based hydrogels: their applications as shape-memory materials, self-healing matrices and controlled drug release systems

2019 ◽  
Vol 10 (30) ◽  
pp. 4106-4115 ◽  
Author(s):  
Gilad Davidson-Rozenfeld ◽  
Lucas Stricker ◽  
Julian Simke ◽  
Michael Fadeev ◽  
Margarita Vázquez-González ◽  
...  
Keyword(s):  
Drug Release ◽  
Nucleic Acids ◽  
Shape Memory ◽  
Carboxymethyl Cellulose ◽  
Controlled Drug Release ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Shape Memory Materials ◽  
Responsive Hydrogels

Carboxymethyl cellulose functionalized with nucleic acids, β-cyclodextrin and arylazopyrazole photoisomerizable units self-assembles into stimuli-responsive hydrogels.

scholarly journals Crosslinked carboxymethyl cellulose-SiO2 hidrogels fabrication: Composition and thermal stability towards biomedical applications

2020 ◽  
Vol 5 (1) ◽  
pp. 60-71
Author(s):  
David Patiño-Ruiz
Keyword(s):  
Thermal Stability ◽  
Drug Release ◽  
Physicochemical Properties ◽  
Carboxymethyl Cellulose ◽  
Sio2 Nanoparticles ◽  
Controlled Drug Release ◽  
Material Composition ◽  
Average Particle ◽  
Amide Bonds ◽  
Pharmaceutical Applications

Novel and innovative materials for biomedical and pharmaceutical applications have to consider several factors during their fabrication, such as the material composition and thermal stability, aiming to establish the promising physicochemical properties towards efficient and controlled drug release systems. In this study, carboxymethyl cellulose (CMC) hydrogels are prepared by incorporating silica dioxide (SiO2) nanoparticles previously modified with primary amine (-NH2) functional groups. The carbodiimide chemistry method is performed to promote the crosslinking of the CMC structure through the formation of amide bonds from the activation of carboxyl (C=O) groups and further covalent binding with -NH2 groups. The morphology information displays high dispersed SiO2 nanoparticles with a smooth surface, regular shape, and an average particle size of 104 nm. The material composition and thermal stability are evaluated using the Fourier transform infrared spectroscopy and thermogravimetric analysis to establish a preliminary overview of a functional hydrogel for biomedical and pharmaceutical applications. The formation of amide bonds is confirmed indicating the successful crosslinking of the CMC structure with SiO2-NH2 nanoparticles, which is attributed to the activation of the C=O groups and its strong affinity to the -NH2 groups. This interaction enhanced the thermal stability of the crosslinked CMC-SiO2 hydrogels up to 469°C which was the last decomposition event, outstanding the contribution of major content of SiO2-NH2 nanoparticles. These preliminary results suggest a suitable procedure for the fabrication of crosslinked CMC-SiO2 hydrogels as novel materials with promising physicochemical properties, allowing to proceed with further research works related to the controlled drug release and delivery.

scholarly journals Sodium Tri Poly Phosphate Mediated Synthesis of Curcumin Loaded Chitosan-Carboxymethyl Cellulose Microparticles for Drug Delivery

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Antony V. Samrot ◽  
SenthilKumar P. ◽  
Shashi Bhushan ◽  
Rishi Kurup ◽  
Ujjala Burman ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Drug Release ◽  
Carboxymethyl Cellulose ◽  
Encapsulation Efficiency ◽  
Sodium Tripolyphosphate ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Infra Red ◽  
Drug Encapsulation Efficiency ◽  
Scanning Electron

In this study, curcumin (CUR) was encapsulated into chitosan (CS) and carboxymethyl cellulose (CMC) microparticles using sodium tripolyphosphate (TPP) as chelator. Here, different concentrations (0.1%, 0.3% and 0.5%) of sodium tripolyphosphate (TPP) were utilised to synthesise microparticles. Microparticles were characterized by Fourier Transform Infra-Red Microscopy (FTIR) and Scanning Electron Microscope (SEM). All the CUR encapsulated microparticles were analysed for their drug encapsulation efficiency and the drug release kinetics. Microparticles were studied for the invitro controlled drug release against Pseudomonas aeruginosa.

Remote magnetically controlled drug release from electrospun composite nanofibers: design of a smart platform for therapy of psoriasis

2020 ◽  
Vol 75 (7) ◽  
pp. 587-591
Author(s):  
Natália Babincová ◽  
Oldřich Jirsák ◽  
Melánia Babincová ◽  
Peter Babinec ◽  
Mária Šimaljaková
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Efficient Method ◽  
Large Scale ◽  
Composite Nanofibers ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Nano Fiber

AbstractAn efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

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