Neurocognitive functioning in preschool children with sickle cell disease

2021 ◽  
Author(s):  
Andrew M. Heitzer ◽  
Diana L. Cohen ◽  
Victoria I. Okhomina ◽  
Ana Trpchevska ◽  
Brian Potter ◽  
...  
Keyword(s):  
Preschool Children ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Neurocognitive Functioning ◽  
Cell Disease

Enhanced Parenting Knowledge and Skills in Mothers of Preschool Children with Sickle Cell Disease

1993 ◽  
Vol 18 (5) ◽  
pp. 575-591 ◽  
Author(s):  
Wendy B. Schuman ◽  
F. Daniel Armstrong ◽  
Charles H. Pegelow ◽  
Donald K. Routh
Keyword(s):  
Preschool Children ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Knowledge And Skills ◽  
Parenting Knowledge

scholarly journals Neurocognitive Functioning and Magnetic Resonance Imaging in Children With Sickle Cell Disease

2000 ◽  
Vol 25 (7) ◽  
pp. 503-513 ◽  
Author(s):  
R. T. Brown ◽  
P. C. Davis ◽  
R. Lambert ◽  
L. Hsu ◽  
K. Hopkins ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Neurocognitive Functioning ◽  
Resonance Imaging ◽  
Cell Disease

Transcranial Doppler Ultrasonography and Neurocognitive Functioning in Children With Sickle Cell Disease

PEDIATRICS ◽  
2003 ◽  
Vol 112 (2) ◽  
pp. 324-331 ◽  
Author(s):  
M. C. Kral ◽  
R. T. Brown ◽  
P. J. Nietert ◽  
M. R. Abboud ◽  
S. M. Jackson ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Transcranial Doppler ◽  
Doppler Ultrasonography ◽  
Transcranial Doppler Ultrasonography ◽  
Neurocognitive Functioning ◽  
Cell Disease

scholarly journals Neurocognitive functioning in symptomatic adults with sickle cell disease: A description and comparison with unaffected siblings

2019 ◽  
Vol 30 (9) ◽  
pp. 1666-1681 ◽  
Author(s):  
Staci Martin ◽  
Marie Claire Roderick ◽  
Cristina Abel ◽  
Pamela Wolters ◽  
Mary Anne Toledo-Tamula ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Neurocognitive Functioning ◽  
Cell Disease

scholarly journals Altered Neurophysiological Processing of Auditory Attention in Preschool Children With Sickle Cell Disease

2017 ◽  
Vol 43 (8) ◽  
pp. 856-869 ◽  
Author(s):  
Michelle Downes ◽  
Fenella J Kirkham ◽  
Paul T Telfer ◽  
Michelle de Haan
Keyword(s):  
Preschool Children ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Auditory Attention ◽  
Cell Disease

High Failure Rate with Brigance Developmental Screening in 3 Year-Old Children with Sickle Cell Disease

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4926-4926
Author(s):  
Winfred C. Wang ◽  
Molly Beth Freeman ◽  
Yvonne M. Carroll ◽  
Latacha Hamilton ◽  
Matthew P. Smeltzer ◽  
...  
Keyword(s):  
Preschool Children ◽  
Sickle Cell Disease ◽  
Failure Rate ◽  
Sickle Cell ◽  
Demographic Factors ◽  
Income Level ◽  
Control Group ◽  
Cell Disease ◽  
Medical Factors ◽  
Control Subjects

Abstract Background: Central nervous system complications of sickle cell disease (SCD) include stroke, silent cerebral infarct, and neurocognitive deficits, but few studies have examined developmental delays in preschool-age children. Using the Brigance developmental screen in 3 year-old children with SCD we found a high frequency of scores below the “normal” cutoff for age, but control data were lacking (Ped. Blood Cancer 2011;56:620). We hypothesized that children with SCD would be more likely to “fail” this screening test than age-matched children from a similar ethnic/socio-economic background. Methods: This prospective study was approved by the St. Jude Children’s Research Hospital (SJCRH) IRB and informed consent obtained for each subject. 3.0-3.9 year-old SCD subjects were tested in the SJCRH Sickle Cell Clinic. Patients receiving chronic transfusion therapy were excluded. Age-matched and race-matched control subjects with similar socio-economic backgrounds were recruited from 8 Memphis daycare centers. The Brigance Preschool Screen was administered by trained examiners in the clinic or the daycare and required about 15 minutes to complete; the primary caretaker simultaneously completed the demographic form. None of the participants had previous exposure to the test. The proportions of subjects who failed the Brigance test (scoring below the age-related “cutoff”) and test raw scores (higher scores indicating better performance) were compared between SCD and control subjects using the exact Chi-square test and the two-sample t-test, respectively; logistic regression was used to model the associations between the Brigance failure proportions and other covariates for the groups. P-values <0.05 were considered significant. Results: Testing was performed on 103 SCD subjects not on treatment, an additional 20 HbSS subjects receiving hydroxyurea (HU), and 109 daycare subjects. Seventy-four percent of children with SCD (not on HU) failed the Brigance screen, compared to 61% of controls (p = 0.04). Mean (SD) Brigance raw scores for the non-HU SCD patients and controls were 45.9 (20.8) and 56.1 (22.5), respectively (p < 0.001). In the non-HU SCD group the pass/fail rate was not significantly different in those with more severe (SS, Sβ0thal) and milder (SC, Sβ+thal) genotypes. Medical factors, including absolute neutrophil count, hemoglobin concentration, %HbF level and O2saturation by pulse oximetry, were not associated with Brigance results. In contrast, socio-economic/demographic factors had a significant effect on the scores: lower income level, more household children under age 18, and more household residents were associated with increased failure (p </= 0.03). Lower caretaker education level showed a similar trend (p = 0.065). None of the socio-economic/demographic factors were associated with failure in the control group, although there was a trend toward failure with more household children under age 18 (p = 0.07). HU-treated SCD children were not significantly different from untreated patients in the failure rate (p = 0.4) and had no significant associations with medical or socio-economic factors. Conclusions: Among 3-year-olds tested with the Brigance Developmental Screen, a higher proportion of children with SCD failed compared to matched controls, but both groups showed a surprisingly high rate. Medical factors, such as hemoglobin level and sickle cell genotype, were not associated with the failure rate, nor was treatment with HU in a limited number of subjects. Socio-demographic factors (income level and numbers of household members) were associated with the failure rate in the SCD group, but not in the control group. These data indicate that preschool children with SCD are at very high risk for developmental delay, and underlying environmental factors seem to contribute more than medical factors. More detailed neurocognitive evaluation of preschool children with SCD and effective ways to enhance their development are needed. Disclosures Off Label Use: Hydroxyurea for children with sickle cell disease.

Radiographic Predictors of Neurocognitive Functioning in Pediatric Sickle Cell Disease

2006 ◽  
Vol 21 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Mary C. Kral ◽  
Ronald T. Brown ◽  
Joel K. Curé ◽  
Nada Besenski ◽  
Sherron M. Jackson ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Neurocognitive Functioning ◽  
Cell Disease ◽  
Pediatric Sickle Cell Disease

EXAMINER Executive Function Battery and Neurologic Morbidity in Pediatric Sickle Cell Disease

2013 ◽  
Vol 20 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Jeffrey Schatz ◽  
Melita Stancil ◽  
Tal Katz ◽  
Carmen E. Sanchez
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cognitive Abilities ◽  
Clinical History ◽  
Neurocognitive Functioning ◽  
Cell Disease ◽  
Cognitive Measures ◽  
Blood Disorder ◽  
Matched Comparison ◽  
Pediatric Sickle Cell Disease

AbstractSickle cell disease (SCD) is blood disorder with a high risk for cerebral vascular morbidities that impact neurocognitive functioning. Specific cognitive abilities are known to be more sensitive to neurologic effects of SCD than IQ scores, yet there is little consensus about which measures to use to assess neurocognitive functioning. We evaluated the ability of the Executive Abilities: Methods and Instruments for Neurobehavioral Evaluation and Research (EXAMINER) Battery to detect neurologic effects in SCD. Thirty-two youth with SCD and sixty demographically-matched comparison youth completed the EXAMINER Battery and selected tests from the Woodcock-Johnson Tests of Cognitive Ability, 3rd edition (WJ-III). Neurologic severity was examined via clinical history for morbidities and midsagittal corpus callosum (CC) area. Results indicated cognitive performance decreased with increasing neurologic morbidity across all cognitive measures; two of four EXAMINER factors were related to CC area. The association with clinical history and midsagittal CC area appeared at least as large for the Examiner Battery scores as for the WJ-III measures. The Examiner Battery showed sensitivity to neurologic history and white matter effects in SCD; this new measure compares favorably to established measures of disease-related neurocognitive effects, but would benefit from further development. (JINS, 2014, 1, 1–12)

Language and Motor Skills of Preschool Children with Sickle Cell Disease

1997 ◽  
Vol 84 (2) ◽  
pp. 486-486 ◽  
Author(s):  
Betholyn Gentry ◽  
Beverly Tolbert Hayes ◽  
Jess Dancer ◽  
Priscilla Davis
Keyword(s):  
African American ◽  
Preschool Children ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Motor Skills ◽  
Language Skills ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Cell Disease

Language skills of 9 African-American preschool children with sickle cell disease were not significantly different from those of nondiseased children but gross and fine motor skills were.

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