Pediatric Philadelphia chromosome‐positive B‐lymphoblastic lymphoma with testicular relapse: A case report

2021 ◽  
Author(s):  
Ryo Maemura ◽  
Hirotoshi Sakaguchi ◽  
Nao Yoshida ◽  
Daiki Yamashita ◽  
Daichi Sajiki ◽  
...  
Keyword(s):  
Case Report ◽  
Philadelphia Chromosome ◽  
Lymphoblastic Lymphoma ◽  
B Lymphoblastic Lymphoma ◽  
Philadelphia Chromosome Positive

scholarly journals An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Prajwal Boddu ◽  
C. Cameron Yin ◽  
Rashmi Kanagal-Shamanna ◽  
Guillin Tang ◽  
Beenu Thakral ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Kinase Inhibitors ◽  
Bone Marrow Involvement ◽  
Philadelphia Chromosome ◽  
Lymphoblastic Lymphoma ◽  
Accurate Diagnosis ◽  
Biopsy Specimens ◽  
B Lymphoblastic Lymphoma ◽  
Prophylactic Chemotherapy

While rare, cases of isolated extramedullary disease of B-cell Lymphoblastic Lymphoma (B-LBL) without morphologic bone marrow involvement have been described. In this report, we illustrate the case of an elderly gentleman who presented with isolated testicular and vertebral LBL involvement but had no morphologic bone marrow involvement. The initial plan of treatment was to treat along the lines of Philadelphia negative B-ALL/LBL. During this time, fluorescence in situ hybridization (FISH) and PCR testing for BCR-ABL1 rearrangements were being performed on the marrow specimens as a part of routine diagnostic workup. While the FISH returned negative, PCR testing unexpectedly detected BCR-ABL1 fusion transcripts at a low level of 0.48%. Given their presence, we performed FISH for BCR/ABL1 rearrangement in both testicular and L5 vertebral specimens which were 80–90% positive. He subsequently received rituximab, hyper-CVAD, and dasatinib, along with prophylactic intrathecal prophylactic chemotherapy. The patient achieved a prolonged remission but eventually relapsed, 4 years later. Had it not been for this fortuitous discovery, the patient would not have been treated with tyrosine kinase inhibitors. We emphasize that FISH and PCR testing for BCR-ABL1 rearrangement are integral to arriving at an accurate diagnosis and should be routinely tested on B-LBL biopsy specimens.

Philadelphia chromosome positive B-cell lymphoblastic lymphoma isolated to bone

2013 ◽  
Vol 54 (9) ◽  
pp. 2052-2054 ◽  
Author(s):  
Hossein Sadrzadeh ◽  
Amelia E. Huck ◽  
Yi-Bin Chen ◽  
Robert P. Hasserjian ◽  
Amir T. Fathi
Keyword(s):  
B Cell ◽  
Philadelphia Chromosome ◽  
Lymphoblastic Lymphoma ◽  
Philadelphia Chromosome Positive

scholarly journals Precursor B-lymphoblastic Lymphoma Involving an Intracardiac Mass and Myocardial Infiltration: A Case Report

2012 ◽  
Vol 51 (3) ◽  
pp. 315-319 ◽  
Author(s):  
Masahiro Manabe ◽  
Yumi Yoshii ◽  
Satoru Mukai ◽  
Erina Sakamoto ◽  
Hiroshi Kanashima ◽  
...  
Keyword(s):  
Case Report ◽  
Lymphoblastic Lymphoma ◽  
Intracardiac Mass ◽  
B Lymphoblastic Lymphoma

scholarly journals “Double hit” B-lymphoblastic lymphoma with concurrent IGH/BCL2 and 8q24/MYC translocations: a case report

2021 ◽  
Vol 10 (3) ◽  
pp. 1594-1598
Author(s):  
Lu He ◽  
Zhiwen Li ◽  
Xiangshan Fan ◽  
Jieyu Chen ◽  
Hongyan Wu ◽  
...  
Keyword(s):  
Case Report ◽  
Lymphoblastic Lymphoma ◽  
Double Hit ◽  
B Lymphoblastic Lymphoma

scholarly journals Primary lumbar spinal epidural b-lymphoblastic lymphoma: A case report

2018 ◽  
Vol 29 (11) ◽  
Author(s):  
Hongyuan Liu ◽  
Lin Wang ◽  
Ying Ren ◽  
Qi Zhong ◽  
Zongping Li ◽  
...  
Keyword(s):  
Case Report ◽  
Lymphoblastic Lymphoma ◽  
B Lymphoblastic Lymphoma ◽  
Lumbar Spinal ◽  
Spinal Epidural

Precursor B Lymphoblastic Lymphoma Restricted to the Central Nervous System: A Case Report

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Michael William Lawlor ◽  
Scott R Plotkin ◽  
Robert P Hasserjian ◽  
E. Tessa Hedley‐Whyte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Lymphoblastic Lymphoma ◽  
System A ◽  
The Central Nervous System ◽  
B Lymphoblastic Lymphoma
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