Changes in executive function in pediatric brain tumor survivors

2021 ◽  
Author(s):  
Rachel K. Peterson ◽  
Lisa A. Jacobson
Keyword(s):  
Brain Tumor ◽  
Executive Function ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain

scholarly journals Executive Function and Psychosocial Adjustment in Adolescent Survivors of Pediatric Brain Tumor

2021 ◽  
pp. 1-20
Author(s):  
A. Puhr ◽  
E. Ruud ◽  
V. Anderson ◽  
B.J. Due-Tønnessen ◽  
A.B. Skarbø ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Executive Function ◽  
Psychosocial Adjustment ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain

scholarly journals Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors

2016 ◽  
pp. now163 ◽  
Author(s):  
Erika Roddy ◽  
Katherine Sear ◽  
Erin Felton ◽  
Benita Tamrazi ◽  
Karen Gauvain ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Executive Function ◽  
Pediatric Brain Tumor ◽  
Cerebral Microbleeds ◽  
Pediatric Brain

scholarly journals RO-02CEREBRAL MICROBLEEDS ARE ASSOCIATED WITH WORSE EXECUTIVE FUNCTION IN PEDIATRIC BRAIN TUMOR SURVIVORS

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii159.2-iii159 ◽  
Author(s):  
Erika Roddy ◽  
Katherine Sear ◽  
Erin Felton ◽  
Benita Tamrazi ◽  
Karen Gauvain ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Executive Function ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain

The Pediatric Brain Tumor Preclinical Testing Program: an update on the current status

2012 ◽  
Vol 224 (06) ◽  
Author(s):  
T Milde ◽  
M Zucknick ◽  
M Kool ◽  
A Korshunov ◽  
H Witt ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Pediatric Brain Tumor ◽  
Current Status ◽  
Preclinical Testing ◽  
Testing Program ◽  
Pediatric Brain

scholarly journals A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yiqun Zhang ◽  
Fengju Chen ◽  
Lawrence A. Donehower ◽  
Michael E. Scheurer ◽  
Chad J. Creighton
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Tyrosine Kinases ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain Tumors ◽  
Altered Expression ◽  
Critical Pathways ◽  
Cis Regulation ◽  
Or Gene ◽  
Pediatric Brain

AbstractThe global impact of somatic structural variants (SSVs) on gene expression in pediatric brain tumors has not been thoroughly characterised. Here, using whole-genome and RNA sequencing from 854 tumors of more than 30 different types from the Children’s Brain Tumor Tissue Consortium, we report the altered expression of hundreds of genes in association with the presence of nearby SSV breakpoints. SSV-mediated expression changes involve gene fusions, altered cis-regulation, or gene disruption. SSVs considerably extend the numbers of patients with tumors somatically altered for critical pathways, including receptor tyrosine kinases (KRAS, MET, EGFR, NF1), Rb pathway (CDK4), TERT, MYC family (MYC, MYCN, MYB), and HIPPO (NF2). Compared to initial tumors, progressive or recurrent tumors involve a distinct set of SSV-gene associations. High overall SSV burden associates with TP53 mutations, histone H3.3 gene H3F3C mutations, and the transcription of DNA damage response genes. Compared to adult cancers, pediatric brain tumors would involve a different set of genes with SSV-altered cis-regulation. Our comprehensive and pan-histology genomic analyses reveal SSVs to play a major role in shaping the transcriptome of pediatric brain tumors.

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