Childhood acute lymphoblastic leukemia treatment in an academic hospital in Kenya: Treatment outcomes and health‐care providers’ perspectives

2021 ◽  
Author(s):  
Gilbert Olbara ◽  
Thyra Wijk ◽  
Festus Njuguna ◽  
Sandra Langat ◽  
Henry Mwangi ◽  
...  
Keyword(s):  
Health Care ◽  
Acute Lymphoblastic Leukemia ◽  
Treatment Outcomes ◽  
Health Care Providers ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Care Providers ◽  
Academic Hospital ◽  
Leukemia Treatment

Health-care providers' compliance with childhood acute lymphoblastic leukemia protocol in Indonesia

2008 ◽  
Vol 51 (6) ◽  
pp. 732-736 ◽  
Author(s):  
Mei Neni Sitaresmi ◽  
Saskia Mostert ◽  
Chad M. Gundy ◽  
Sutaryo ◽  
Anjo J.P. Veerman
Keyword(s):  
Health Care ◽  
Acute Lymphoblastic Leukemia ◽  
Health Care Providers ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Care Providers

Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment

2018 ◽  
Vol 19 (18) ◽  
pp. 1403-1412 ◽  
Author(s):  
Ángela Gutierrez-Camino ◽  
Maitane Umerez ◽  
Elixabet Lopez-Lopez ◽  
Borja Santos-Zorrozua ◽  
Idoia Martin-Guerrero ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemia Treatment

Influence of Socioeconomic Status on Childhood Acute Lymphoblastic Leukemia Treatment in Indonesia

PEDIATRICS ◽  
2006 ◽  
Vol 118 (6) ◽  
pp. e1600-e1606 ◽  
Author(s):  
S. Mostert ◽  
M. N. Sitaresmi ◽  
C. M. Gundy ◽  
Sutaryo ◽  
A. J. P. Veerman
Keyword(s):  
Socioeconomic Status ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemia Treatment

Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia treatment

Bone ◽  
2010 ◽  
Vol 46 (4) ◽  
pp. 1016-1020 ◽  
Author(s):  
Alessandro Mussa ◽  
Nicoletta Bertorello ◽  
Francesco Porta ◽  
Chiara Galletto ◽  
Mario Guido Nicolosi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Bone Ultrasound ◽  
Leukemia Treatment

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia

Blood ◽  
2002 ◽  
Vol 100 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Stella M. Davies ◽  
Smita Bhatia ◽  
Julie A. Ross ◽  
William R. Kiffmeyer ◽  
Paul S. Gaynon ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Treatment Outcomes ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Environmental Carcinogens ◽  
Glutathione S Transferase ◽  
Gene Frequencies ◽  
Childhood All ◽  
Chemotherapy Drugs ◽  
Genotype Frequencies

Abstract The glutathione S-transferase (GST) genes are involved in the metabolism of environmental carcinogens and of some classes of chemotherapy drugs. GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. Previous, smaller studies of childhood acute lymphoblastic leukemia (ALL) provided contrasting data on the role of the GST genotype in susceptibility and treatment outcomes. We analyzed GST genotypes in 710 children with ALL treated by the Children's Cancer Group. Frequencies were compared with those of normal controls, and outcomes were analyzed according to genotype. Comparisons of gene frequencies in ALL case and control patients showed similar frequencies (54% vs 53% GSTM1 null in whites,P = .9; 40% versus 32% in blacks,P = .45; 16% versus 15% GSTT1 null in whites,P = .8; 17% versus 28% in blacks,P = .3). ALL was not associated with the GSTM1-null genotype or the double-null genotype in blacks or whites, in contrast to previous reports. Stratification of cases by age at diagnosis, sex, white blood cell count at diagnosis, B or T lineage, or cytogenetics revealed no differences in genotype frequencies. Analysis of treatment outcomes showed no differences in outcome according to GST genotype; in particular, there were no differences in frequencies of relapse at any site. These data, representing a larger series than any reported previously, suggest that GST genotype does not affect etiology or outcome of childhood ALL.

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