Phase‐specific risks of outpatient visits, emergency visits, and hospitalizations during Children's Oncology Group‐based treatment for childhood acute lymphoblastic leukemia: A population‐based study

2021 ◽  
Author(s):  
Mylene Bassal ◽  
Mariana Silva ◽  
Serina Patel ◽  
Paul J. Gibson ◽  
Vicky R. Breakey ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Population Based ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Oncology Group ◽  
Population Based Study ◽  
Emergency Visits ◽  
Outpatient Visits

Infections and the development of childhood acute lymphoblastic leukemia: a population-based study

2020 ◽  
Vol 29 (6) ◽  
pp. 538-545
Author(s):  
Jeremiah Hwee ◽  
Rinku Sutradhar ◽  
Jeffrey C. Kwong ◽  
Lillian Sung ◽  
Stephanie Cheng ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Population Based ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Population Based Study

scholarly journals Secondary Solid Organ Neoplasm in Patients with Acute Lymphoblastic Leukemia: A Nationwide Population-Based Study in Taiwan

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0152909
Author(s):  
Chung-Jen Teng ◽  
Leh-Kiong Huon ◽  
Yu-Wen Hu ◽  
Chiu-Mei Yeh ◽  
Sheng-Hsuan Chien ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Population Based ◽  
Solid Organ ◽  
Population Based Study

scholarly journals Venous Thromboembolism and Its Risk Factors in Children with Acute Lymphoblastic Leukemia in Israel: A Population-Based Study

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2759
Author(s):  
Shlomit Barzilai-Birenboim ◽  
Ronit Nirel ◽  
Nira Arad-Cohen ◽  
Galia Avrahami ◽  
Miri Ben Harush ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Univariate Analysis ◽  
Population Based ◽  
Population Based Study ◽  
Inherited Thrombophilia ◽  
Severe Hypertriglyceridemia

Venous thromboembolism (VTE) is a serious complication of acute lymphoblastic leukemia (ALL) therapy. The aim of this population-based study was to evaluate the rate, risk factors, and long-term sequelae of VTE in children treated for ALL. The cohort included 1191 children aged 1–19 years diagnosed with ALL between 2003–2018, prospectively enrolled in two consecutive protocols: ALL-IC BFM 2002 and AIEOP-BFM ALL 2009. VTEs occurred in 89 patients (7.5%). Long-term sequelae were uncommon. By univariate analysis, we identified four significant risk factors for VTEs: Severe hypertriglyceridemia (p = 0.005), inherited thrombophilia (p < 0.001), age >10 years (p = 0.015), and high-risk ALL group (p = 0.039). In addition, the incidence of VTE was significantly higher in patients enrolled in AIEOP-BFM ALL 2009 than in those enrolled in ALL-IC BFM 2002 (p = 0.001). Severe VTE occurred in 24 children (2%), all of whom had at least one risk factor. Elevated triglyceride levels at diagnosis did not predict hypertriglyceridemia during therapy. In a multivariate analysis of 388 children, severe hypertriglyceridemia and inherited thrombophilia were independent risk factors for VTE. Routine evaluation for these risk factors in children treated for ALL may help identify candidates for intervention.

Sign in / Sign up

Export Citation Format

Share Document