scholarly journals Impact of COVID‐19 on adolescent and emerging adult brain tumor survivors and their parents

2021 ◽  
Author(s):  
Allison P. Fisher ◽  
Jamie Patronick ◽  
Cynthia A. Gerhardt ◽  
Krestin Radonovich ◽  
Ralph Salloum ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Emerging Adult ◽  
Adult Brain

Rehabilitation pathways in adult brain tumor patients in the first 12 months of disease. A retrospective analysis of services utilization in 719 patients

2016 ◽  
Vol 24 (11) ◽  
pp. 4801-4806 ◽  
Author(s):  
Andrea Pace ◽  
Veronica Villani ◽  
Cristiano Parisi ◽  
Stefano Di Felice ◽  
Margaux Lamaro ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Retrospective Analysis ◽  
Adult Brain ◽  
Tumor Patients ◽  
Services Utilization

scholarly journals Quality of Life Among Parents of Adolescent and Young Adult Brain Tumor Survivors

2017 ◽  
Vol 39 (8) ◽  
pp. 579-584 ◽  
Author(s):  
David K. Buchbinder ◽  
Michelle A. Fortier ◽  
Kathryn Osann ◽  
Justin Wilford ◽  
Violet Shen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumor ◽  
Young Adult ◽  
Adult Brain ◽  
Adolescent And Young Adult

Ischemic Stroke Risk Among Adult Brain Tumor Survivors

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Karl Cristie F. Figuracion ◽  
Wonkyung Jung ◽  
Sarah R. Martha
Keyword(s):  
Ischemic Stroke ◽  
Brain Tumor ◽  
Stroke Risk ◽  
Adult Brain ◽  
Ischemic Stroke Risk

Brain Tumors

2016 ◽  
pp. 11-24 ◽  
Author(s):  
Chikezie Eseonu ◽  
Jordina Rincon-Torroella ◽  
Alfredo Quiñones-Hinojosa
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Demyelinating Disease ◽  
Brain Lesion ◽  
Pituitary Tumors ◽  
Current Treatment ◽  
Preoperative Care ◽  
Adult Brain ◽  
Surgical Approaches

Brain tumor cases make up a significant part of the neurosurgery Oral Board Exam. A multitude of brain tumors exist and can be intraaxial or extraaxial. When considering a differential diagnosis for a brain lesion, infection, hematomas, infarctions, thrombosed aneurysms, inflammation, and demyelinating disease must be considered in addition to tumors. Common adult brain tumors consist of gliomas, meningiomas, metastases, and pituitary tumors. Management of brain tumors consists of understanding preoperative care, indications for surgery, surgical approaches, interpretation of preoperative and postoperative imaging, intraoperative and postoperative complications, and the role of adjuvant therapy, including chemotherapy and radiotherapy. Reviewing these essential points for the most common brain tumor cases and mastering the current treatment recommendations for common tumors will also be helpful for the boards.

scholarly journals TMIC-56. ROLE OF HUMAN BRAIN TUMOR STEM CELLS-DERIVED EXTRACELLULAR VESICLES ON THE PHENOTYPIC TRANSDIFFERENTIATION OF HUMAN NEURAL PROGENITOR CELLS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi260-vi260
Author(s):  
Natanael Zarco ◽  
Emily Norton ◽  
Montserrat Lara-Velazquez ◽  
Anna Carrano ◽  
Alfredo Quinones-Hinojosa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Tumor Microenvironment ◽  
Extracellular Vesicles ◽  
Primary Cultures ◽  
Adult Brain ◽  
Cell Subpopulation ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

Abstract Glioblastoma (GBM) is the most aggressive of all the brain tumors with a median patient survival less than 15 months. Despite of surgical resection, radiotherapy, and chemotherapy, recurrence rate is almost 100%. A great percentage of GBM tumors (~60%) infiltrate and contact the ventricular-subventricular zone (V-SVZ). Interestingly, these tumors are the most aggressive, and invariably lead to higher distal recurrence rates, shorter time to tumor progression, and lower overall survival of the patient. The reason for this role of V-SVZ-proximity on the outcome of GBM patients is unknown. We suggest that a potential explanation is the interaction of GBM with the V-SVZ. This region is the largest neurogenic niche in the adult brain where neural stem cells (NSCs) give rise to newborn neuroblasts that migrate toward the olfactory bulb. In GBM there is a cell subpopulation called brain tumor stem cells (BTSCs) with NSCs-like characteristics, but with added potential for tumor initiation, recurrence and invasiveness. Tumor microenvironment plays an important role in migration and invasion process. In the present work, we used the total exosome isolation kit to purify Extracellular Vesicles (EVs) from human primary cultures of BTSCs. We determined that BTSCs-derived EVs contain specific information that is transfer to primary cultures of human Neural Progenitors Cells (NPCs) modulating their proliferation rate, cell viability, and migration. In addition, we identify that NPCs taken up BTSCs-derived EVs and significantly increase the expression levels of stemness-related genes such as Nestin, Nanog, and Sox2, suggesting that a phenotypic transdifferentiation is being carry out. These results support our hypothesis that GBM modulate the tumor microenvironment close to the V-SVZ by releasing EVs that target cellular components in this region and promote their phenotypic transformation, highlighting that NPCs biology changes in the context of tumor environment.

scholarly journals APELA Expression in Glioma, and Its Association with Patient Survival and Tumor Grade

2019 ◽  
Vol 12 (1) ◽  
pp. 45 ◽  
Author(s):  
Debolina Ganguly ◽  
Chun Cai ◽  
Michelle Sims ◽  
Chuan Yang ◽  
Matthew Thomas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Tumor ◽  
Patient Survival ◽  
Receptor Gene ◽  
Embryonic Stem ◽  
Tumor Grade ◽  
Adult Brain ◽  
Tumor Initiating Cells ◽  
Apelin Receptor ◽  
Cell Niche

Glioblastoma (GBM) is the most common and deadliest primary adult brain tumor. Invasion, resistance to therapy, and tumor recurrence in GBM can be attributed in part to brain tumor-initiating cells (BTICs). BTICs isolated from various patient-derived xenografts showed high expression of the poorly characterized Apelin early ligand A (APELA) gene. Although originally considered to be a non-coding gene, the APELA gene encodes a protein that binds to the Apelin receptor and promotes the growth of human embryonic stem cells and the formation of the embryonic vasculature. We found that both APELA mRNA and protein are expressed at high levels in a subset of brain tumor patients, and that APELA is also expressed in putative stem cell niche in GBM tumor tissue. Analysis of APELA and the Apelin receptor gene expression in brain tumor datasets showed that high APELA expression was associated with poor patient survival in both glioma and glioblastoma, and APELA expression correlated with glioma grade. In contrast, gene expression of the Apelin receptor or Apelin was not found to be associated with patient survival, or glioma grade. Consequently, APELA may play an important role in glioblastoma tumorigenesis and may be a future therapeutic target.

scholarly journals 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Disha Sood ◽  
Min Tang-Schomer ◽  
Dimitra Pouli ◽  
Craig Mizzoni ◽  
Nicole Raia ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Adult Brain ◽  
Metabolic Imaging ◽  
Tumor Type ◽  
Label Free ◽  
Pediatric Ependymoma ◽  
Extracellular Lipid ◽  
Tumor Cell Behavior

Abstract Dynamic alterations in the unique brain extracellular matrix (ECM) are involved in malignant brain tumors. Yet studies of brain ECM roles in tumor cell behavior have been difficult due to lack of access to the human brain. We present a tunable 3D bioengineered brain tissue platform by integrating microenvironmental cues of native brain-derived ECMs and live imaging to systematically evaluate patient-derived brain tumor responses. Using pediatric ependymoma and adult glioblastoma as examples, the 3D brain ECM-containing microenvironment with a balance of cell-cell and cell-matrix interactions supports distinctive phenotypes associated with tumor type-specific and ECM-dependent patterns in the tumor cells’ transcriptomic and release profiles. Label-free metabolic imaging of the composite model structure identifies metabolically distinct sub-populations within a tumor type and captures extracellular lipid-containing droplets with potential implications in drug response. The versatile bioengineered 3D tumor tissue system sets the stage for mechanistic studies deciphering microenvironmental role in brain tumor progression.

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