Childhood venous thromboembolism—A careful look at complete blood count can reveal the underlying risk factor

2020 ◽  
Vol 67 (8) ◽  
Author(s):  
Aaqib Zaffar Banday ◽  
Reva Tyagi ◽  
Suchit Jogu ◽  
Murugan Sudhakar ◽  
Pratap Kumar Patra ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Blood Count ◽  
Complete Blood Count ◽  
Underlying Risk Factor ◽  
Underlying Risk

Longitudinal associations between inhibitory control and externalizing and internalizing symptoms in school-aged children

2020 ◽  
pp. 1-13
Author(s):  
Katri Maasalo ◽  
Jallu Lindblom ◽  
Olli Kiviruusu ◽  
Päivi Santalahti ◽  
Eeva T. Aronen
Keyword(s):  
Risk Factor ◽  
Inhibitory Control ◽  
Internalizing Symptoms ◽  
Psychiatric Symptoms ◽  
Externalizing Symptoms ◽  
Causal Role ◽  
Trait Level ◽  
Underlying Risk Factor ◽  
Externalizing And Internalizing Symptoms ◽  
Underlying Risk

Abstract Inhibitory control (IC) deficits have been associated with psychiatric symptoms in all ages. However, longitudinal studies testing the direction of the associations in childhood are scarce. We used a sample of 2,874 children (7 to 9 years old) to test the following three hypotheses: (a) IC deficits are an underlying risk factor with a potentially causal role for psychopathology, (b) IC deficits are a complication of psychopathology, and (c) IC deficits and psychopathology are associated at the trait level but not necessarily causally related. We used the go/no-go task to assess IC, the parent-rated Strengths and Difficulties Questionnaire to evaluate externalizing/internalizing symptoms, and the random intercepts cross-lagged panel model to test the hypotheses. The results showed no support for the underlying risk factor hypothesis, suggesting that IC unlikely has a causal role in this age group's psychopathology. The complication hypothesis received support for externalizing symptoms, suggesting that externalizing symptoms may hamper the normal development of IC. IC deficits and both externalizing and internalizing symptoms were correlated at the trait level, indicating a possible common origin. We suggest that it may be useful to support children with externalizing symptoms to promote and protect their IC development.

MATERNAL OBESITY AND OXIDATIVE STRESS IN THE FETUS: MECHANISMS UNDERLYING EARLY LIFE SHIFTS IN SKELETAL MUSCLE METABOLISM

2011 ◽  
Vol 22 (3) ◽  
pp. 219-246
Author(s):  
KRISTEN E BOYLE ◽  
JACOB E FRIEDMAN
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Maternal Obesity ◽  
Muscle Metabolism ◽  
Obese Women ◽  
Maternal Risk ◽  
Metabolic Outcome ◽  
Underlying Risk Factor ◽  
Adipose Tissue Lipolysis ◽  
Underlying Risk

The most common maternal risk factor associated with neonatal complications during delivery is obesity. Although gestational diabetes mellitus (GDM) occurs in 5–10% of the pregnant population, obesity, by virtue of its prevalence, far outpaces GDM as the most important underlying risk factor for increased fetal adiposity. The mechanisms underlying maternal insulin resistance may play an important role in the diversion of excess fuels to the fetus. Maternal adipose depots increase in early pregnancy, followed by increased adipose tissue lipolysis and subsequent hyperlipidaemia, which mainly corresponds to increased triglyceride levels (TG). A positive correlation between maternal TG and infant body weight or fat mass has been found in both GDM and non-GDM obese women. Increased oxidative stress, altered adipokines, and inflammatory cytokines have also been found in obese pregnant women, suggesting an adverse metabolic outcome even in normoglycemic conditions.

The Prevalence and Risk Factors of Iron Deficiency Anemia in Thai Infants by Complete Blood Count at 9-Month-Old

2020 ◽  
Vol 103 (9) ◽  
pp. 891-896
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Exclusive Breastfeeding ◽  
Blood Count ◽  
Complete Blood Count ◽  
Deficiency Anemia ◽  
Iron Treatment ◽  
Baby Clinic

Background: Infants are the most at risk from iron deficiency (ID) and iron deficiency anemia (IDA), but the prevalence of the latter in this group is unclear. Estimation as to the prevalence of IDA using Hb of less than 11 g/dL may have been exaggerated due to thalassemia and hemoglobinopathies. On the other hand, iron studies are costly and not routinely available in low resource settings. In the present research, the authors estimated the prevalence of IDA in 9-month-old infants at the authors’ well-baby clinic by improving the post-iron-treatment criteria of Hb and defined the risk factors of IDA in infants. Objective: To estimate the prevalence of IDA in 9-month-old infants at the well-baby clinic and to define the risk factors of IDA. Materials and Methods: A retrospective cohort study of 391 children who had complete blood count (CBC) screening at 9-month-old at the well-baby clinic. Anemia was defined according to the WHO criteria (hemoglobin of 11 g/dL or less for children aged six months to five years). IDA was defined as an increase of at least Hb 1 g/dL after receiving iron treatment for one to two months. Mean levels of hematological parameters were compared between groups using independent samples t-test. The characteristics with potential risk factors for IDA were compared with iron non-responder and normal group. Multivariable adjusted odd ratios and 95% confidence intervals (CIs) of IDA were calculated using multinomial logistic regression with control for risk factors. Results: One hundred fourteen children (29.1%) were anemic. There was no difference between anemic and non-anemic children in baseline characteristics. Seventy children in the anemic group were diagnosed with IDA. The prevalence of IDA in the present study was 17.9%. The IDA group showed significant improvement in Hb, Hct, MCV, MCH after receiving iron treatment, but there were no significant changes in the iron non-responder group. The risk factor for IDA was exclusive breastfeeding for at least six months (odds ratio 3.14, 95% CI 1.67 to 5.90, p<0.001). Conclusion: The prevalence of IDA and anemia in the present study was 17.9% and 29.1%, respectively. The risk factor for IDA was exclusive breastfeeding for at least six months. Keywords: Anemia, Iron deficiency anemia, Prevalence of anemia in infants, Complete blood count screening, Thai infants

Normal-tension glaucoma and Alzheimer’s disease: Helicobacter pylori as a possible common underlying risk factor

2007 ◽  
Vol 68 (1) ◽  
pp. 228-229 ◽  
Author(s):  
Jannis Kountouras ◽  
Christos Zavos ◽  
Emmanuel Gavalas ◽  
Marina Boziki ◽  
Dimitrios Chatzopoulos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Helicobacter Pylori ◽  
Risk Factor ◽  
Normal Tension Glaucoma ◽  
Underlying Risk Factor ◽  
Underlying Risk

scholarly journals Influenza A (H1N1) pandemic vaccination – an underlying risk factor for many CNS complications in Brazil

2015 ◽  
Vol 73 (1) ◽  
pp. 72-72
Author(s):  
Gustavo Bruniera Peres Fernandes ◽  
Sergio Tufik ◽  
Fernando Morgadinho Santos Coelho
Keyword(s):  
Risk Factor ◽  
Influenza A ◽  
H1n1 Pandemic ◽  
Influenza A H1n1 ◽  
Underlying Risk Factor ◽  
Underlying Risk
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