Trends in conditional survival and predictors of late death in neuroblastoma

2020 ◽  
Vol 67 (10) ◽  
Author(s):  
Hannah E. Olsen ◽  
Kevin Campbell ◽  
Rochelle Bagatell ◽  
Steven G. DuBois
Keyword(s):  
Conditional Survival ◽  
Late Death

Trends in conditional survival and predictors of late death in neuroblastoma.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 10533-10533
Author(s):  
Hannah Olsen ◽  
Kevin M. Campbell ◽  
Rochelle Bagatell ◽  
Steven G. DuBois
Keyword(s):  
Overall Survival ◽  
High Risk ◽  
Risk Group ◽  
High Risk Group ◽  
Primary Site ◽  
Conditional Survival ◽  
Late Death ◽  
High Risk Patients ◽  
Risk Patients ◽  
Over Time

10533 Background: Significant advances in the treatment of neuroblastoma have been made in the past several decades. There are scant data examining how these improvements have changed over time and differentially affected conditional survival among high- and non-high-risk patient groups. Methods: We conducted a retrospective cohort study using the Surveillance, Epidemiology, and End Results Database. We analyzed clinical characteristics and survival outcomes for 4717 neuroblastoma patients. Kaplan-Meier methods were used to estimate overall survival (OS) and conditional overall survival (COS) conditioned on having survived 1, 2, or 5 years from diagnosis, with estimates compared between groups using log-rank tests. Results: Five-year OS was 41.46% (95% CI 38.77-44.13) for the high-risk group and 91.13% (95% CI 89.49-92.53) for the non-high-risk group. Both groups saw significant improvements in OS by decade (p<0.001). Five-year COS among 1-year survivors was 52.69% (95% CI 38.77-44.13) for the high-risk group and 96.75% (95% CI 95.57-97.62) for the non-high-risk group. One-year survivors in the high-risk group showed a statistically significant improvement in COS over time. No difference in COS was observed among 5-year high-risk survivors. There were no statistically significant changes in COS over time for 1- and 5-year survivors in the non-high-risk group. In the high-risk and non-high-risk groups, 82% and 32% of late deaths (>5 years from diagnosis) were attributable to cancer, respectively. Statistically significant adverse prognostic factors for late death were age >1 year at diagnosis, metastatic disease, and non-thoracic primary site (p=0.001). Conclusions: Improvements in COS over time have largely benefited high-risk patients, though they are still at higher risk for late death due to cancer when compared to non-high-risk patients. Age, stage, and primary site, but not treatment decade, influence outcomes among 5-year survivors. [Table: see text]

Conditional Survival and Predictors of Late Death in Patients With Ewing Sarcoma

2016 ◽  
Vol 63 (6) ◽  
pp. 1091-1095 ◽  
Author(s):  
Jillian R. Davenport ◽  
Kieuhoa T. Vo ◽  
Robert Goldsby ◽  
Daniel C. West ◽  
Steven G. DuBois
Keyword(s):  
Ewing Sarcoma ◽  
Conditional Survival ◽  
Late Death

AB0460 Causes of Early and Late Death of Patients with Systemic Lupus Erythematosus over A 10-Year Period:

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 1063.3-1064
Author(s):  
I. Padjen ◽  
M. Erceg ◽  
M. Cerovec ◽  
M. Mayer ◽  
R. Stevanović ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Late Death

scholarly journals What Are the Conditional Survival and Functional Outcomes After Surgical Treatment of 115 Patients With Sacral Chordoma?

2016 ◽  
Vol 475 (3) ◽  
pp. 620-630 ◽  
Author(s):  
Tao Ji ◽  
Wei Guo ◽  
Rongli Yang ◽  
Xiaodong Tang ◽  
Yifei Wang ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Functional Outcomes ◽  
Conditional Survival ◽  
Sacral Chordoma
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