Association of perioperative red blood cell transfusion with postoperative venous thromboembolism in pediatric patients: A propensity score matched analysis

2019 ◽  
Author(s):  
David H. Rothstein ◽  
Sarah B. Cairo ◽  
Beverly A. Schaefer ◽  
Timothy B. Lautz
Keyword(s):  
Venous Thromboembolism ◽  
Propensity Score ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Pediatric Patients ◽  
Red Blood Cell Transfusion

Association of Perioperative Red Blood Cell Transfusion With Symptomatic Venous Thromboembolism Following Total Hip and Knee Arthroplasty

2021 ◽  
Vol 36 (1) ◽  
pp. 325-330
Author(s):  
Aaron Jackson ◽  
Karan Goswami ◽  
Michael Yayac ◽  
Timothy L. Tan ◽  
Samuel Clarkson ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Blood Cell ◽  
Knee Arthroplasty ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Total Hip ◽  
Hip And Knee Arthroplasty

scholarly journals A retrospective analysis of venous thromboembolism trends in chemotherapy‐induced anemia: Red blood cell transfusion versus erythrocyte stimulating agent administration

eJHaem ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 35-43
Author(s):  
Emily J. Bryer ◽  
Michael J. Kallan ◽  
Ting‐Shan Chiu ◽  
Katharina M. Scheuba ◽  
David H. Henry
Keyword(s):  
Venous Thromboembolism ◽  
Blood Cell ◽  
Retrospective Analysis ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion

A retrospective analysis of venous thromboembolism trends in chemotherapy-induced anemia: Red blood cell transfusion versus erythrocyte stimulating agent (ESA) administration.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e14685-e14685
Author(s):  
Emily Jane Bryer ◽  
David H. Henry
Keyword(s):  
Venous Thromboembolism ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Absolute Risk ◽  
Subsequent Development ◽  
Intravenous Iron ◽  
Red Blood Cell Transfusion ◽  
Chemotherapy Patients ◽  
Poor Outcomes ◽  
Rbc Transfusion

e14685 Background: Anemia is a common and unfortunate consequence of chemotherapy; patients receiving a variety of chemotherapy regimens often develop chemotherapy–induced anemia (CIA), which contributes to poor outcomes including increased mortality. Prompt and effective treatment of CIA is essential to prevent fewer chemotherapy dose delays and reductions. Optimal therapy of CIA is controversial and involves the solitary and combined use of intravenous iron, red blood cell (RBC) transfusions, and erythropoietin stimulating agents (ESAs). Despite the baseline coagulopathies present in patients with malignancy, administration of both RBC transfusions and ESAs is associated with venous thromboembolism (VTE). It remains unknown whether the risk of VTE in patients with CIA is greater among patients who receive RBC transfusions or ESAs. Methods: A retrospective single-institution study analyzed 7360 patients with varying malignancies who developed CIA and received ESAs and RBC transfusion from 1998-2017. These patients were evaluated for subsequent development of VTE and categorized by prior receipt of RBC transfusion or ESA. Results: Among the 7360 patients with CIA, 5503 received either RBC transfusion or ESA and 1857 received both. Among all patients, 3466/7360 (47.1%) developed a VTE. The absolute risk of developing a VTE with receipt of a RBC transfusion was 0.38 compared to 0.19 with ESA. Patients with CIA who received RBC had twice the risk of developing a VTE compared with those who received ESA (p < 0.0001). Conclusions: While both RBC transfusion and ESA administration are independently associated with VTE, our data suggests a greater risk of VTE development with RBC transfusion as compared with ESA administration.[Table: see text]

scholarly journals The Impact of Perioperative Packed Red Blood Cell Transfusion on Survival in Epithelial Ovarian Cancer

2013 ◽  
Vol 23 (9) ◽  
pp. 1612-1619 ◽  
Author(s):  
Lindsay L. Morgenstern Warner ◽  
Sean C. Dowdy ◽  
Janice R. Martin ◽  
Maureen A. Lemens ◽  
Michaela E. McGree ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Propensity Score ◽  
Blood Cell ◽  
Epithelial Ovarian Cancer ◽  
Propensity Score Matching ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Improvement Program ◽  
Estimated Blood Loss ◽  
The Impact

ObjectivePerioperative packed red blood cell transfusion (PRBCT) has been implicated as a negative prognostic marker in surgical oncology. There is a paucity of evidence on the impact of PRBCT on outcomes in epithelial ovarian cancer (EOC). We assessed whether PRBCT is an independent risk factor of recurrence and death from EOC.MethodsPerioperative patient characteristics and process-of-care variables (defined by the National Surgical Quality Improvement Program) were retrospectively abstracted from 587 women who underwent primary EOC staging between January 2, 2003, and December 29, 2008. Associations with receipt of PRBCT were evaluated using univariate logistic regression models. The associations between receipt of PRBCT and disease-free survival and overall survival were evaluated using multivariable Cox proportional hazards models and using propensity score matching and stratification, respectively.ResultsThe rate of PRBCT was 77.0%. The mean ± SD units transfused was 4.1 ± 3.1 U. In the univariate analysis, receipt of PRBCT was significantly associated with older age, advanced stage (≥IIIA), undergoing splenectomy, higher surgical complexity, serous histologic diagnosis, greater estimated blood loss, longer operating time, the presence of residual disease, and lower preoperative albumin and hemoglobin. Perioperative packed red blood cell transfusion was not associated with an increased risk for recurrence or death, in an analysis adjusting for other risk factors in a multivariable model or in an analysis using propensity score matching or stratification to control for differences between the patients with and without PRBCT.ConclusionsPerioperative packed red blood cell transfusion does not seem to be directly associated with recurrence and death in EOC. However, lower preoperative hemoglobin was associated with a higher risk for recurrence. The need for PRBCT seems to be a stronger prognostic indicator than the receipt of PRBCT.

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