scholarly journals Childhood neoplasms presenting at autopsy: A 20-year experience

2017 ◽  
Vol 64 (9) ◽  
pp. e26474 ◽  
Author(s):  
Victoria A. Bryant ◽  
John Booth ◽  
Liina Palm ◽  
Michael Ashworth ◽  
Thomas S. Jacques ◽  
...  
Keyword(s):  
Childhood Neoplasms

scholarly journals miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms

2012 ◽  
Vol 33 (5) ◽  
pp. 1014-1021 ◽  
Author(s):  
U. Senanayake ◽  
S. Das ◽  
P. Vesely ◽  
W. Alzoughbi ◽  
L. F. Frohlich ◽  
...  
Keyword(s):  
Childhood Neoplasms ◽  
Common Target

WILMS' TUMOR AND CONGENITAL HEMIHYPERTROPHY: REPORT OF FIVE NEW CASES AND REVIEW OF LITERATURE

PEDIATRICS ◽  
1967 ◽  
Vol 40 (5) ◽  
pp. 886-899
Author(s):  
Joseph F. Fraumeni ◽  
Clementina F. Geiser ◽  
Miriam D. Manning
Keyword(s):  
Cancer Research ◽  
Adrenal Cortex ◽  
Wilms Tumor ◽  
Cytogenetic Study ◽  
Congenital Defect ◽  
Familial Occurrence ◽  
Review Of Literature ◽  
Childhood Neoplasms ◽  
Congenital Hemihypertrophy

Among 225 patients with Wilms' tumor seen at the Children's Cancer Research Foundation in Boston, 7 had congenital hemihypertrophy (a frequency of 1:32), bringing to 26 the number of cases reported in the literature with this association. In one child the cytogenetic study of leukocyte cultures revealed elongation of the long arms of both No. 16 chromosomes; each parent and two of four siblings had a similar anomaly affecting one chromosome of pair 16. Dermatoglyphics on this patient and three others in the series were unremarkable, as were studies of urinary gonadotropin excretion. From a review of all cases reported with Wilms' tumor and hemihypertrophy, little was found to indicate a relationship to other disorders, such as Silver's syndrome or neurofibromatosis, in which hemihypertrophy has been described. A role of inheritance was suggested in our series by one patient who had a sibling with hemihypertrophy, the seventh reported familial occurrence of this congenital defect. From the sparse evidence available, it would appear that the origins of hemihypertrophy are heterogeneous and include genic, chromosomal, and other factors which are presently obscure. The association between hemihypertrophy and Wilms' tumor may reflect common etiologic factors or a pre-neoplastic anlage in "hemihypertrophic" kidneys. Since hemihypertrophy seems to be related also to childhood neoplasms originating in the adrenal cortex and liver, further research on this anomaly should enhance our understanding of oncogenic mechanisms.

Childhood. Leukemia in Southwest Sardinia (Italy)

1993 ◽  
Vol 79 (4) ◽  
pp. 244-245
Author(s):  
Pierluigi Cocco ◽  
Luisa Bernardinelli ◽  
Pierfranco Biddau ◽  
Cristina Montomoli ◽  
Giulio Murgia ◽  
...  
Keyword(s):  
Childhood Leukemia ◽  
Spatial Clustering ◽  
Lymphoblastic Leukemia ◽  
Environmental Pollutants ◽  
Incidence Rates ◽  
Childhood Cancers ◽  
Childhood All ◽  
Urban Settlements ◽  
Childhood Neoplasms ◽  
The Town

Aim and background Public concern on an increased incidence of childhood leukemia in SW Sardinia prompted the authors to an epidemiological investigation. Methods Incident childhood neoplasms observed in the Cagliari province (Sardinia - Italy) in 1974-1989 were registered. Expected cases of the most frequent childhood cancers were calculated for each town, based on the sex-and age-specific incidence rates in the province. Results An excess risk of childhood acute lymphoblastic leukemia (ALL) was observed in Carbonia, a town located in the SW part of the province. The risk was highest in 1983-85, when 7 cases occurred versus 0.8 expected (RR = 8.7; 95 % C.I. = 4.6, 16.3). No spatial clustering of ALL cases was observed within the town. Conclusions A significantly higher than expected incidence of childhood ALL was observed in the town of Carbonia in 1983-85. In alternative to chance, possible exposure to environmental pollutants from a near industrial settlement is discussed as the cause of the observed excess, but it is far to be proven. Other hypotheses, including a viral infection in a population with increased susceptibility, as suggested for new urban settlements, cannot be discarded.

Large germline copy number variations as predisposing factor in childhood neoplasms

2014 ◽  
Vol 10 (9) ◽  
pp. 1627-1633 ◽  
Author(s):  
Ana Cristina Victorino Krepischi ◽  
Leonardo Pires Capelli ◽  
Amanda Gonçalves Silva ◽  
Érica Sara Souza de Araújo ◽  
Peter Lees Pearson ◽  
...  
Keyword(s):  
Copy Number ◽  
Copy Number Variations ◽  
Predisposing Factor ◽  
Childhood Neoplasms

Pleuropulmonary Blastoma and its association with other childhood neoplasms

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 8542-8542 ◽  
Author(s):  
Y. H. Messinger ◽  
L. P. Dehner ◽  
D. A. Hill ◽  
G. Williams ◽  
J. R. Priest
Keyword(s):  
Pleuropulmonary Blastoma ◽  
Childhood Neoplasms

scholarly journals A Rare and Unusual Case of Burkitt’s Lymphoma Presenting with a Prostate Mass in a 12-Year-Old Boy

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
N. Sinclair ◽  
P. Babyn ◽  
M. Kinloch ◽  
R. Sinha
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Unusual Case ◽  
Alveolar Bone ◽  
Burkitt’S Lymphoma ◽  
Definitive Diagnosis ◽  
Burkitt's Lymphoma ◽  
Radiographic Findings ◽  
Dental Abscess ◽  
Childhood Neoplasms ◽  
History Of

Burkitt’s lymphoma is the most frequent subtype of non-Hodgkin’s lymphoma in childhood. Radiographic findings are protean and can often overlap with other neoplastic and nonneoplastic processes. We present an unusual case of Burkitt’s lymphoma in a 12-year-old boy presenting with a one-week history of urinary retention, dysuria, and “tailbone pain,” as well as a 4-week history of jaw pain, initially treated as a dental abscess. On dental radiography, the patient was found to have resorption of alveolar bone adjacent to the lower first molars bilaterally, in keeping with “floating teeth,” classically associated with Langerhans cell histiocytosis. Additionally, a large, eccentric, prostatic mass was noted, prompting the inclusion of rhabdomyosarcoma on the differential diagnosis, with subsequent definitive diagnosis of Burkitt’s lymphoma on tissue and bone marrow biopsy. This case highlights the imaging overlap of these childhood neoplasms with an unusual lymphomatous prostate mass. It is important that the radiologists and pediatricians be aware of this potential overlap and the unusual presentation of Burkitt’s lymphoma.

U. S. Mortality from Letterer-Siwe Disease, 1960-1964

PEDIATRICS ◽  
1968 ◽  
Vol 42 (2) ◽  
pp. 364-367
Author(s):  
Andrew G. Glass ◽  
Robert W. Miller
Keyword(s):  
United States ◽  
The United States ◽  
Childhood Neoplasms

Study of mortality in the United States from Letterer-Siwe Disease revealed a striking concentration of deaths in the first 2 years of life and aggregation in five sets of siblings, including one pair of twins. These findings indicate that Letterer-Siwe disease (in common with certain childhood neoplasms) has prenatal origins.

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