Anaplastic Ependymoma in a Child With Sickle Cell Anemia: A Case Report Highlighting Treatment Challenges for Young Children With Central Nervous System Tumors and Underlying Vasculopathy

2015 ◽  
Vol 63 (3) ◽  
pp. 547-550 ◽  
Author(s):  
Erin E. Crotty ◽  
Emily R. Meier ◽  
Elizabeth M. Wells ◽  
Eugene I. Hwang ◽  
Roger J. Packer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Young Children ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Central Nervous System Tumors ◽  
Anaplastic Ependymoma ◽  
Nervous System Tumors

Multiple central nervous system tumors, neurofibromatosis type 2, a case report

2015 ◽  
Vol 8 (1) ◽  
pp. 55-58
Author(s):  
Nedim Ongun ◽  
Eylem Değirmenci ◽  
Çağdaş Erdoğan ◽  
Attila Oğuzhanoğlu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors

scholarly journals Embryonal tumor with multilayered rosettes of the fourth ventricle: case report

2015 ◽  
Vol 16 (5) ◽  
pp. 579-583 ◽  
Author(s):  
Catherine A. Edmonson ◽  
Kristin J. Weaver ◽  
Jesse Kresak ◽  
David W. Pincus
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Fourth Ventricle ◽  
Molecular Mechanisms ◽  
Clinical Course ◽  
Molecular Profile ◽  
Central Nervous System Tumors ◽  
Embryonal Tumor ◽  
Nervous System Tumors

Embryonal tumor with multilayered rosettes (ETMR) is a recently described pathological entity. These primitive central nervous system tumors harbor amplification of the 19q13.42 locus and resultant overexpression of the LIN28A protein. Although the WHO currently recognizes 3 distinct histopathological entities—embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma—recent studies indicate that these tumors have a common molecular profile and clinical course and that they are now classified as a single entity. Here the authors present a case of ETMR located in the fourth ventricle in a 12-month-old boy. The histopathology featured areas of neuropil-like stroma and highly cellular foci with characteristic multilayered rosettes. The authors discuss the clinical, radiological, and histopathological findings in this case and compare them with data in previously published cases in the literature. A review of studies assessing the molecular mechanisms underlying these tumors is also presented.

Abnormalities of the central nervous system in very young children with sickle cell anemia

1998 ◽  
Vol 132 (6) ◽  
pp. 994-998 ◽  
Author(s):  
Winfred C. Wang ◽  
James W. Langston ◽  
R.Grant Steen ◽  
Lynn W. Wynn ◽  
Raymond K. Mulhern ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Young Children ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Very Young Children ◽  
The Central Nervous System
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