Intra-Arterial Platelet Infusion for Intractable Hemorrhage and Refractory

2015 ◽  
Vol 62 (12) ◽  
pp. 2226-2228 ◽  
Author(s):  
Issam M. Kably ◽  
Edward D. Ziga ◽  
Martin Andreansky
Keyword(s):  
Platelet Infusion

scholarly journals Inability to Reverse Aspirin and Clopidogrel-induced Platelet Dysfunction with Platelet Infusion

Cureus ◽  
2019 ◽  
Author(s):  
Stephen M Cohn ◽  
Jean-Carlos Jimenez ◽  
Leen Khoury ◽  
Javier Martin Perez ◽  
Melissa Panzo
Keyword(s):  
Platelet Dysfunction ◽  
Platelet Infusion

Release of High Levels of Platelet Factor 4 (PF4) from Platelets Improves Survival after a Lethal Lipopolysaccharide (LPS) Challenge.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 61-61
Author(s):  
M. Anna Kowalska ◽  
Michele P. Lambert ◽  
Lubica Rauova ◽  
William J. Smith ◽  
Shawn A. Mahmud ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Physiological Role ◽  
Protein C Deficiency ◽  
Platelet Factor ◽  
Lps Challenge ◽  
Inflammatory State ◽  
Platelet Infusion

Abstract Infusion of activated protein C (APC) improves survival in sepsis. PF4 is a CXC chemokine predominantly expressed during megakaryopoiesis and stored in platelet alpha-granules whose biological function(s) are not well understood. We have shown that recombinant PF4 enhances APC generation by thrombin/thrombomodulin complexes both in vitro and in vivo. Would endogenous PF4 released from platelets activated during an inflammatory state similarly affect APC production? We addressed this issue using mice that were either completely devoid of PF4 (mPF4−/−) or had a 6-fold excess of human PF4 (hPF4+). Using a lethal LPS challenge model (O111:B4, 40 mg/kg IP), we examined whether platelets become activated and release PF4 during endotoxemia. Two hours after LPS injection, the platelet count in mice decreased to ~70% of baseline levels (p=0.006). Serum PF4, as measured by ELISA, also dropped to ~60% of baseline from 47±5 kU/ml to 30±5 kU/ml (p=0.002). At the same time, plasma PF4 level was increased by 20%, consistent with LPS resulting in PF4 release. The smaller increase than expected suggests that much of the released PF4 binds immediately to the surface of vascular cells. Consistent with this, we have observed higher accumulation of PF4 in mouse lungs after LPS injection compared to uninjected mice (990±220 and 660±120 U/mg, respectively, p=0.017). APC generation was assessed 10 min after thrombin infusion (80 U/kg. IV) as a measure of endogenous platelet PF4’s effect in an inflammatory/procoagulant state. In mPF4−/− mice APC levels were 72% of that in wild type (WT) mice (p=0.0006) while in hPF4+ mice APC formation increased to 178% (p=0.003). Survival of mice 24 hrs after LPS (25 mg/kg) challenge was then examined. hPF4+ mice had a mortality rate of 9% compared to ~40% in both WT and mPF4−/− (p< 0.001). To examine the role of APC in this improved survival, we performed similar experiments with mice heterozygous for protein C deficiency (PC+/−). More PC+/− mice died 16 hrs after injection of 40 mg/kg LPS than WT mice (61% vs. 29% mortality respectively, p=0.005), while mortality for hPF4+/PC+/− mice was significantly lower (14%, p< 0.001 compared to PC+/− mice), supporting the hypothesis that the protective effect of PF4 is at least in part due to increased APC generation. Next we asked if infusion of platelets with high PF4 is protective in the LPS model. We injected either vehicle buffer or mPF4−/− or hPF4+ platelets (3×108 per 20 g mouse) into WT mice prior to treatment with LPS. Mortality of mice at 24 hrs after LPS injection with mPF4−/−platelet infusion was not significantly different than mice with buffer infusion (86% vs. 96% respectively, p=0.4), but mortality was significantly lower when hPF4+ platelets were infused (58% vs. 96%, p=0.01). Our results suggest that PF4 is released from platelets after an inflammatory stimulus and that this may have a positive physiological role by enhancing APC generation. High endogenous platelet PF4 levels may have a survival advantage after exposure to endotoxins. Infusion of platelets containing high levels of PF4 in sepsis may be a novel therapeutic strategy that warrants further investigation.

Platelet infusion-related echocardiographic contrast

1990 ◽  
Vol 66 (2) ◽  
pp. 244 ◽  
Author(s):  
Jean-Jacques Monsuez ◽  
Jean-Michel Miclea ◽  
Pauline Brice ◽  
Laurent Chauveinc ◽  
Michel Boiron
Keyword(s):  
Platelet Infusion

scholarly journals Treatment with Decitabine Followed By Prednisone for Myelodysplatic Syndrome Concomitant with Sjogren's Syndrome

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5530-5530
Author(s):  
Xingfu Sun ◽  
Jianyong Li ◽  
Hua Lu
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Conflicts Of Interest ◽  
Bone Marrow Examination ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Effective Option ◽  
Platelet Infusion ◽  
Stimulating Factor ◽  
Sjögren‘S Syndrome

Abstract Myelodysplastic Syndrome (MDS) is rarely concomitant with Sjögren's syndrome (SS) with only 9 previously reported cases in the literature. A case of a previously healthy 31-year-old Chinese female presenting with dysplasia affecting all three lineages without blasts excess showed by bone marrow examination is reported. Autoimmune workup revealed positive antinuclear antibodies and Anti-SSA. Lip biopsy revealed findings consistent with SS. A diagnosis of SS associated with MDS of the refractory cytopenia with multilineage dysplasia (RCMD) subtype was established, and decitabine for five days at 20mg/m2 per day was initiated with only slight increase in platelet counts. Four weeks later, another cycle of decitabine for five days at 20mg/m2 per day was performed. Unfortunately, infection occurred, and the patient suffered from thrombocytopenia and leucopenia. Then the patient received the treatment of Biapenem and Vancomycin Hydrochloride along with granulocyte colony stimulating factor followed by platelet infusion for two weeks. Significant clinical and laboratory response was achieved. In hopes of improving both response rates and durability of response, the third cycle of decitabine for five days at 20mg/m2 per day was performed with again an excellent clinical and laboratory response. However the patient refused further cycle of decitabine due to cost consideration, then prednisone at 10mg per day was used as a basic treatment for SS. It was an amazing feat that the patient was in a state of remission for two years. MDS with SS tends to be incurable. Decitabine alone with prednisone may serve as an effective option to those patients. Disclosures No relevant conflicts of interest to declare.

Anesthesia Management of Children With Head and Neck Hemangiomas Associated With the Kasabach–merritt Phenomenon

2020 ◽  
Author(s):  
mingyang sun ◽  
Ningtao Li ◽  
Enqiang Chang ◽  
Xiaoguo Ruan ◽  
Hui Zhi ◽  
...  
Keyword(s):  
Head And Neck ◽  
Anesthetic Management ◽  
Young Patients ◽  
Neck Region ◽  
Surgical Excision ◽  
Postoperative Recovery ◽  
Glucocorticoid Treatment ◽  
Platelet Counts ◽  
Anesthesia Management ◽  
Platelet Infusion

Abstract Background: We reported the anesthesia management of the patients with head and neck hemangiomas associated with the Kasabach–Merritt phenomenon (KMP).Methods: All 12 young patients with KMP involving the head and neck region who admitted in Henan Provincial Hospital for surgery between June 2012 and December 2016 were included in the study. The data during preoperative preparation including platelet infusion and glucocorticoid treatment, anesthetic management and postoperative recovery were were harvested and analysed.Results: Of the 12 patients, the platelet counts were less than 40× 109/L on admission but no gender difference and three of them responded to glucocorticoid treatment extremely well. The patients who did not respond glucocorticoid treatment well and whose platelets <40× 109/L were transfused platelets 12 hours prior to surgery to correct the platelet count to be equal or more than 100 × 109/L. The patients who had pneumonia before surgery had a prolonged hospital stay. All 12 patients had surgical excision successfully. After surgery, the platelet counts were increased rapidly in all patients.Conclusion Careful pre-anesthesia assessment and preparation, and thoughtful anesthesia management are needed for KMP patients to receive surgical excision.

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