Cerebral white matter fractional anisotropy and tract volume as measured by MR imaging are associated with impaired cognitive and motor function in pediatric posterior fossa tumor survivors

2015 ◽  
Vol 62 (7) ◽  
pp. 1252-1258 ◽  
Author(s):  
Stefan M. Rueckriegel ◽  
Harald Bruhn ◽  
Ulrich W. Thomale ◽  
Pablo Hernáiz Driever
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Fractional Anisotropy ◽  
Posterior Fossa ◽  
Motor Function ◽  
Posterior Fossa Tumor ◽  
Cerebral White Matter

scholarly journals Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergoing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Naoki Yamada ◽  
Ryo Ueda ◽  
Wataru Kakuda ◽  
Ryo Momosaki ◽  
Takahiro Kondo ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Transcranial Magnetic Stimulation ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Motor Function ◽  
Magnetic Stimulation ◽  
Diffusion Tensor ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Cerebral White Matter ◽  
Imaging Evaluation

We aimed to investigate plastic changes in cerebral white matter structures using diffusion tensor imaging following a 15-day stroke rehabilitation program. We compared the detection of cerebral plasticity between generalized fractional anisotropy (GFA), a novel tool for investigating white matter structures, and fractional anisotropy (FA). Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) of 2400 pulses applied to the nonlesional hemisphere and 240 min intensive occupation therapy (OT) daily over 15 days. Motor function was evaluated using the Fugl-Meyer assessment (FMA) and Wolf Motor Function Test (WMFT). Patients underwent diffusion tensor magnetic resonance imaging (MRI) on admission and discharge, from which bilateral FA and GFA values in Brodmann area (BA) 4 and BA6 were calculated. Motor function improved following treatment (p<0.001). Treatment increased GFA values for both the lesioned and nonlesioned BA4 (p<0.05, p<0.001, resp.). Changes in GFA value for BA4 of the lesioned hemisphere were significantly inversely correlated with changes in WMFT scores (R2=0.363, p<0.05). Our findings indicate that the GFA may have a potentially more useful ability than FA to detect changes in white matter structures in areas of fiber intersection for any such future investigations.

scholarly journals Neuroimaging of the component white matter connections and structures within the cerebellar-frontal pathway in posterior fossa tumor survivors

2019 ◽  
Vol 23 ◽  
pp. 101894 ◽  
Author(s):  
Alyssa S. Ailion ◽  
Simone Renée Roberts ◽  
Bruce Crosson ◽  
Tricia Z. King
Keyword(s):  
White Matter ◽  
Posterior Fossa ◽  
Posterior Fossa Tumor

scholarly journals Tract-Specific Fractional Anisotropy Predicts Cognitive Outcome in a Community Sample of Middle-Aged Participants with White Matter Lesions

2014 ◽  
Vol 34 (5) ◽  
pp. 861-869 ◽  
Author(s):  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Núria Bargalló ◽  
Juan Francisco Arenillas ◽  
...  
Keyword(s):  
White Matter ◽  
Fractional Anisotropy ◽  
Predictive Value ◽  
Diffusion Tensor ◽  
Community Sample ◽  
White Matter Lesions ◽  
Cognitive Outcome ◽  
Cerebral White Matter ◽  
High Grade ◽  
Middle Aged

Cerebral white matter lesions (WMLs) have been consistently related to cognitive dysfunction but the role of white matter (WM) damage in cognitive impairment is not fully determined. Diffusion tensor imaging is a promising tool to explain impaired cognition related to WMLs. We investigated the separate association of high-grade periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) with fractional anisotropy (FA) in middle-aged individuals. We also assessed the predictive value to cognition of FA within specific WM tracts associated with high-grade WMLs. One hundred participants from the Barcelona-AsIA Neuropsychology Study were divided into groups based on low- and high-grade WMLs. Voxel-by-voxel FA were compared between groups, with separate analyses for high-grade PVHs and DWMHs. The mean FA within areas showing differences between groups was extracted in each tract for linear regression analyses. Participants with high-grade PVHs and participants with high-grade DWMHs showed lower FA in different areas of specific tracts. Areas showing decreased FA in high-grade DWMHs predicted lower cognition, whereas areas with decreased FA in high-grade PVHs did not. The predictive value to cognition of specific WM tracts supports the involvement of cortico-subcortical circuits in cognitive deficits only in DWMHs.

scholarly journals Vestibular Loss and Balance Training Cause Similar Changes in Human Cerebral White Matter Fractional Anisotropy

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95666 ◽  
Author(s):  
Nadine Hummel ◽  
Katharina Hüfner ◽  
Thomas Stephan ◽  
Jennifer Linn ◽  
Olympia Kremmyda ◽  
...  
Keyword(s):  
White Matter ◽  
Fractional Anisotropy ◽  
Balance Training ◽  
Cerebral White Matter ◽  
Vestibular Loss

Transient decrease in cerebral white matter diffusivity on MR imaging in human herpes virus-6 encephalopathy

2005 ◽  
Vol 27 (1) ◽  
pp. 30-33 ◽  
Author(s):  
Manami Akasaka ◽  
Makoto Sasaki ◽  
Shigeru Ehara ◽  
Atsushi Kamei ◽  
Shoichi Chida
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Herpes Virus ◽  
Cerebral White Matter ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Transient Decrease ◽  
Human Herpes Virus 6 ◽  
Herpès Virus

T2 at MR Imaging Is an Objective Quantitative Measure of Cerebral White Matter Signal Intensity Abnormality in Preterm Infants at Term-equivalent Age

Radiology ◽  
2009 ◽  
Vol 252 (1) ◽  
pp. 209-217 ◽  
Author(s):  
Cornelia F. Hagmann ◽  
Enrico De Vita ◽  
Alan Bainbridge ◽  
Roxanna Gunny ◽  
Andrew B. Kapetanakis ◽  
...  
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Preterm Infants ◽  
Signal Intensity ◽  
Quantitative Measure ◽  
Cerebral White Matter ◽  
Equivalent Age
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