Post-thrombotic syndrome after central venous catheter removal in childhood cancer survivors: A prospective cohort study

2014 ◽  
Vol 62 (2) ◽  
pp. 285-290 ◽  
Author(s):  
E. Polen ◽  
M. Weintraub ◽  
C. Stoffer ◽  
D.H. Jaffe ◽  
A. Burger ◽  
...  
Keyword(s):  
Cohort Study ◽  
Central Venous Catheter ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Venous Catheter ◽  
Childhood Cancer Survivors ◽  
Central Venous ◽  
Central Venous Catheter Removal

scholarly journals Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Nandini Vijayakanthi ◽  
Dheeraj Bahl ◽  
Nirmaljit Kaur ◽  
Arti Maria ◽  
Nand Kishore Dubey
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Central Venous Catheter ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Venous Catheter ◽  
Beta Lactamase ◽  
Central Venous ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

This prospective cohort study was conducted to determine the frequency of infections caused by extended-spectrum beta-lactamase- (ESBL-) producing organisms, various bacteria producing ESBL, antibiotic susceptibility of these organisms, and the risk factors associated with these infections in a neonatal intensive care unit in a tertiary care hospital in North India. Of the 150 neonates enrolled in the study, 47 culture-positive neonates were included in the study cohort and were divided into two groups: ESBL-positive (8 neonates) and ESBL-negative (39 neonates) cohorts. Various organisms were isolated from 72 culture samples in these 47 neonates. Of these, 10 culture samples grew ESBL-positive organisms and 62 samples grew ESBL-negative organisms. The frequency of ESBL-producing organisms was found to be 5.3%. ESBL infection incidence densities were found to be 3.4 per 1000 patient-days.Klebsiella(60%) was the most common organism producing ESBL followed byEscherichia coli(30%) andPseudomonas(10%). Eighty percent of the ESBL-producing organisms were sensitive to piperacillin-tazobactam. Risk factors found significant by univariate analysis (P<0.05) were preterm, low birthweight, perinatal asphyxia, respiratory distress syndrome, anaemia, metabolic acidosis, prolonged mechanical ventilation (>7 days), length of hospitalization, length of level 3 stay, prior antibiotic use, central venous catheter duration, peripherally inserted central venous catheter duration, and total parenteral nutrition duration. Factors that retained significance in the logistic regression model were duration of hospital stay (adjusted OR: 0.958, CI: 0.920–0.997, andPvalue = 0.037) and gestational age (adjusted OR: 1.39, CI: 1.037–1.865, andPvalue = 0.028). There was no significant difference in the mortality between the two groups.

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