Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: Relation to vasculopathy and disease severity

2014 ◽  
Vol 62 (3) ◽  
pp. 389-394 ◽  
Author(s):  
Azza Abdel Gawad Tantawy ◽  
Amira Abdel Moneam Adly ◽  
Eman Abdel Rahman Ismail ◽  
Shereen Hussiny Aly
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Sickle Cell Disease ◽  
Disease Severity ◽  
Endothelial Nitric Oxide Synthase ◽  
Cell Disease ◽  
Vntr Polymorphism ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Intron 4

Endothelial nitric oxide synthase gene intron 4 a/b VNTR polymorphism in children with APSGN

2006 ◽  
Vol 21 (11) ◽  
pp. 1661-1665 ◽  
Author(s):  
Hasan Dursun ◽  
Aytul Noyan ◽  
Selcuk Matyar ◽  
Mithat Buyukcelik ◽  
Mustafa Soran ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Vntr Polymorphism ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Intron 4

Endothelial Nitric Oxide Synthase Gene Intron 4 (VNTR) Polymorphism and Vascular Access Graft Thrombosis

2007 ◽  
Vol 20 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Ozgur Basaran ◽  
F. Belgin Atac ◽  
Feza Karakayali ◽  
Ibrahim Aliosmanoglu ◽  
Mahmut Can Yagmurdur ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Vascular Access ◽  
Endothelial Nitric Oxide Synthase ◽  
Graft Thrombosis ◽  
Vntr Polymorphism ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Intron 4 ◽  
Access Graft

scholarly journals Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India

2013 ◽  
Vol 58 (12) ◽  
pp. 775-779 ◽  
Author(s):  
Sudhansu Sekhar Nishank ◽  
Mendi Prema Shyam Sunder Singh ◽  
Rajiv Yadav ◽  
Rasik Bihari Gupta ◽  
Vijay Sadashiv Gadge ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Sickle Cell Disease ◽  
Gene Polymorphism ◽  
Sickle Cell ◽  
Endothelial Nitric Oxide Synthase ◽  
Cell Disease ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Endothelial nitric oxide synthase polymorphism and venous thromboembolism: A meta-analysis of 9 studies involving 3993 subjects

2021 ◽  
pp. 026835552110166
Author(s):  
Guangbin Huang ◽  
Xuejun Deng ◽  
Yanan Xu ◽  
Pan Wang ◽  
Tao Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Venous Thromboembolism ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Meta Analysis ◽  
Enos Polymorphism ◽  
The Difference ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Intron 4

Background Endothelial nitric oxide synthase (eNOS) polymorphism may influence the risk of venous thromboembolism (VTE). However, data from published studies with low statistical power are inconclusive. The present meta-analysis aimed to assess the relationship between eNOS polymorphism and the risk of VTE. Method Case-control studies evaluating the association between the eNOS polymorphism and VTE were searched in PubMed, Embase, Web of Science, Google Scholar, Wanfang, Chinese National Knowledge Infrastructure (CNKI), the Chongqing VIP Chinese Science and Technology Periodical Database (VIP), and Chinese Biomedical Literature Database (CBM). Results A total of 1588 cases and 2405 controls from 9 studies were included in the analysis. The results showed that eNOS G894T polymorphism was related to VTE susceptibility and the difference was statistically significant [T vs G: OR = 1.41, 95% CI (1.13, 1.75), P = 0.002; TT + GG vs TG: OR = 0.71, 95% CI (0.60, 0.84), P = 0.000; TT + TG vs GG: OR = 1.45, 95% CI (1.23, 1.70), P = 0.000]. Additionally, eNOS Intron 4 VNTR polymorphism was related to VTE susceptibility and the difference was statistically significant [4b4b vs 4a4a + 4a4b: OR = 2.77, 95% CI (1.01, 7.61), P = 0.048]. Conclusion ENOS G894T and eNOS Intron 4 VNTR polymorphisms were associated with VTE susceptibility, especially in Asian populations. However, multicenter studies with larger samples should be conducted to further clarify this association and verify our findings.

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