A randomized trial of cefozopran versus cefepime as empirical antibiotic treatment of febrile neutropenia in pediatric cancer patients

2014 ◽  
Vol 61 (11) ◽  
pp. 1992-1995 ◽  
Author(s):  
Takeo Sarashina ◽  
Ryoji Kobayashi ◽  
Makoto Yoshida ◽  
Naohisa Toriumi ◽  
Daisuke Suzuki ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Randomized Trial ◽  
Cancer Patients ◽  
Antibiotic Treatment ◽  
Pediatric Cancer ◽  
Empirical Antibiotic Treatment ◽  
Pediatric Cancer Patients

Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia—species distribution and susceptibility patterns

2013 ◽  
Vol 21 (9) ◽  
pp. 2417-2426 ◽  
Author(s):  
Karin G. E. Miedema ◽  
Rik H. L. J. Winter ◽  
Roland A. Ammann ◽  
Sara Droz ◽  
Lodewijk Spanjaard ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Cancer Patients ◽  
Species Distribution ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
Susceptibility Patterns

scholarly journals Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

2019 ◽  
Author(s):  
Husnia Bedewi ◽  
Malede Berihun ◽  
Atalay Mulu ◽  
Tamrat Assefa
Keyword(s):  
Febrile Neutropenia ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Management Practice ◽  
Tertiary Care ◽  
Tikur Anbessa Specialized Hospital ◽  
Definitive Therapy ◽  
Pediatric Cancer Patients ◽  
Culture And Sensitivity ◽  
Study Participants

Abstract Objective This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS 20 for analysis. Results Empiric antibiotics therapy (EAT) was given to all patients in which ceftriaxone with gentamycin constituted of 71.9% followed by ceftriaxone monotherapy. EATs were converted to others in 20 (14.8%) and 2(1.5%) patients for the first and second times respectively, mainly based on poor clinical response without conducting culture and sensitivity tests. These tests were done only for 13 (9.6%) participants and growth was seen in 5 patients; and definitive therapy was given for 2 patients. ANC value was above 500 cell/mm3 in 80.7% of patients and 98.5% of study participants were afebrile after completion FN treatment. Most of them (70.4%) were treated for FN and 7 of patients died due to all case mortality. The hospital should not rely mainly only on ceftriaxone with gentamycin as EAT and also should do culture and sensitivity test to optimize therapy based on susceptibility result before conversion and modification of therapy in management of FN.

scholarly journals Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

2019 ◽  
Author(s):  
Husnia Bedewi ◽  
Malede Berihun ◽  
Atalay Mulu ◽  
Tamrat Assefa
Keyword(s):  
Febrile Neutropenia ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Management Practice ◽  
Tertiary Care ◽  
Tikur Anbessa Specialized Hospital ◽  
Definitive Therapy ◽  
Pediatric Cancer Patients ◽  
Culture And Sensitivity ◽  
Study Participants

Abstract Objective This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS 20 for analysis. Results Empiric antibiotics therapy (EAT) was given to all patients in which ceftriaxone with gentamycin constituted of 71.9% followed by ceftriaxone monotherapy. EATs were converted to others in 20 (14.8%) and 2(1.5%) patients for the first and second times respectively, mainly based on poor clinical response without conducting culture and sensitivity tests. These tests were done only for 13 (9.6%) participants and growth was seen in 5 patients; and definitive therapy was given for 2 patients. ANC value was above 500 cell/mm3 in 80.7% of patients and 98.5% of study participants were afebrile after completion FN treatment. Most of them (70.4%) were treated for FN and 7 of patients died due to all case mortality. The hospital should not rely mainly only on ceftriaxone with gentamycin as EAT and also should do culture and sensitivity test to optimize therapy based on susceptibility result before conversion and modification of therapy in management of FN.

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