Risk of hepatitis B infection in pediatric acute lymphoblastic leukemia in a tertiary care center from South India

2014 ◽  
Vol 61 (9) ◽  
pp. 1616-1619 ◽  
Author(s):  
B. Guruprasad ◽  
S. Kavitha ◽  
B.S. Aruna Kumari ◽  
B.R. Vijaykumar ◽  
B.G. Sumati ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Hepatitis B ◽  
South India ◽  
Lymphoblastic Leukemia ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Hepatitis B Infection ◽  
Pediatric Acute Lymphoblastic Leukemia

scholarly journals Tumor lysis syndrome in pediatric acute lymphoblastic leukemia at tertiary care center

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Bilquis Naeem Memon ◽  
Khemchand N Moorani ◽  
Misbah Anjum ◽  
Uzma Imam
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Care Center ◽  
Tertiary Care ◽  
Tumor Lysis Syndrome ◽  
P Value ◽  
Tertiary Care Center ◽  
Pediatric Acute Lymphoblastic Leukemia ◽  
Tumor Lysis ◽  
Biochemical Abnormalities

Objectives: Tumor lysis syndrome (TLS) is common complication of acute lymphoblastic leukemia (ALL). It is characterized by presence of two or more of hyperkalemia, hyperuricemia, hyperphosphatemia and hypocalcemia. TLS may cause acute kidney injury (AKI), arrhythmias and seizures. Our objective was to determine the frequency of TLS and its biochemical abnormalities in children with ALL. Methods: A retrospective study on 91 children, aged 2-13 years with ALL was carried out in Nephrology and Oncology departments of National Institute of Child Health, Karachi from January 2016 to December 2017. Patients already received chemotherapy were excluded. Data including risk categories, immunophenotyping, laboratory parameters like complete blood picture, serum creatinine (SCr), potassium (K), calcium (Ca), phosphorus (P) and uric acid (UA) on day 0,3 and7 after chemotherapy were collected. Data analyzed on SPSS using descriptive statistics. Independent t- test was applied to compare means and P- value<0.05 was taken as significant. Results: Ninety-one children with mean age of 6.39±3.08 years were studied. Male were 57% and 43% female. High risk ALL were 61.5%. Pre –BALL were 82.4% and 17.5% had T-cell ALL. All patients had anemia (hemoglobin7.69±2.66 g/dl) and thrombocytopenia (43.61± 18.6 x109) where as hyperleukocytosis and blast cells were observed in 20.87% and 73.6% respectively. Comparing the biochemical parameters of ALL, the difference in SCr from D0 vs D3 (0.46±0.16 vs0.54± 0.35 and D7, 0.44±0.22) was significant (p=0.001). Similarly, difference in UA (D0, 4.12±2.40 vs D3, 3.82±1.73 and D7, 3.56±1.42), SP (D0, 4.24±1.34 vs D3, 4.61±1.76 and D7,4.13±1.07mg/dl)and for K (p=0.038) was significant. There was no difference in Ca from D0 vs D3 (0.092) and D7 (0.277). TLS was found in 62.6% children, it was chemotherapy induced in 72% and spontaneous in 28%. Clinical-TLS was observed in 14% and all CTLS had AKI. Hyperuricemia and hyperphosphatemia were the most common biochemical abnormalities in laboratory-TLS and CTLS. Conclusion: TLS was found in 62.6% despite preventive measures. Early recognition and treatment is essential to avoid morbidity and mortality. doi: https://doi.org/10.12669/pjms.35.4.715 How to cite this:Naeem B, Moorani KN, Anjum M, Imam U. Tumor lysis syndrome in pediatric acute lymphoblastic leukemia at tertiary care center. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.715 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Isolated CNS Relapse in Acute Lymphoblastic Leukemia (ALL): An Experience from a Tertiary Care Center

2021 ◽  
Author(s):  
Manvir Singh Tevatia ◽  
Isha Sharma ◽  
Toyaja Jadhav ◽  
Venkatesan Somasundaram ◽  
Sanjeevan Sharma
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Presenting Symptoms ◽  
Cns Relapse ◽  
Definitive Therapy ◽  
The Central Nervous System ◽  
Systemic Relapse

Abstract Aims and Objectives In this study the various parameters of acute lymphoblastic leukemia (ALL), including the clinical features, peripheral blood and bone marrow (BM) findings, immunophenotypic and cytogenetic details in ALL cases who had isolated relapse involving the central nervous system (CNS), were studied. Patients/Materials and Methods Duration of the study is from 2015 to 2019 in which 5 ALL cases were presented to this tertiary care center. The presenting symptoms varied from headache, fever, and distension of abdomen. These cases were either on therapy or post completion of chemotherapy. The diagnosis of CNS relapse followed after the examination of cerebrospinal fluid (CSF). Patients also underwent BM examination to rule out systemic relapse. Results Age of patients ranged from 7 months to 42 years. There were three female patients. Two patients had isolated CNS relapse 3.5 years after completing therapy and succumbed to their illness. Two patients had t(9;22) while one patient had t(1;14) cytogenetic abnormality at diagnosis. One patient was diagnosed as T-ALL. Treatment offered was German Multicentre ALL protocol for induction along with 10 cycles of maintenance. Conclusion The most common hematolymphoid malignancy in children namely ALL accounts for 75% of childhood leukemias. Complete remission rates reach up to 70 to 80%. CNS involvement is known to occur in these cases. CNS relapse may occur alone or with systemic relapse. Advances in therapeutic protocols along with CNS prophylaxis have drastically brought down the rates of CNS relapse. It is essential to maintain a high degree of suspicion so that these cases of isolated CNS relapse can be identified at the earliest and definitive therapy can be offered.

scholarly journals Aberrant myeloid antigen co-expression is correlated with high percentages of CD34-positive cells among blasts of acute lymphoblastic leukemia patients: an Indian tertiary care center perspective

2014 ◽  
Vol 49 (4) ◽  
pp. 241 ◽  
Author(s):  
Rahul Kumar Sharma ◽  
Abhishek Purohit ◽  
Venkatesan Somasundaram ◽  
Pravas Chandra Mishra ◽  
Mrinalini Kotru ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center
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