Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: Effects of a home-based exercise program

2013 ◽  
Vol 60 (9) ◽  
pp. 1546-1551 ◽  
Author(s):  
Liisa S. Järvelä ◽  
Harri Niinikoski ◽  
Olli J. Heinonen ◽  
Päivi M. Lähteenmäki ◽  
Mikko Arola ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Endothelial Function ◽  
Lymphoblastic Leukemia ◽  
Exercise Program ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Home Based ◽  
Long Term Survivors

Neurocognitive Outcome in Very Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia After Treatment with Chemotherapy Only

2015 ◽  
Vol 63 (1) ◽  
pp. 133-138 ◽  
Author(s):  
Adriani Kanellopoulos ◽  
Stein Andersson ◽  
Bernward Zeller ◽  
Christian K. Tamnes ◽  
Anders M. Fjell ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Neurocognitive Outcome ◽  
Long Term Survivors

scholarly journals Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia

Leukemia ◽  
2008 ◽  
Vol 23 (1) ◽  
pp. 104-108 ◽  
Author(s):  
S C Kaste ◽  
N A Thomas ◽  
S N Rai ◽  
K Cheon ◽  
E McCammon ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Kidney Stones ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Long Term Survivors

Chronic Progressive Cardiac Dysfunction Years After Doxorubicin Therapy for Childhood Acute Lymphoblastic Leukemia

2005 ◽  
Vol 23 (12) ◽  
pp. 2629-2636 ◽  
Author(s):  
Steven E. Lipshultz ◽  
Stuart R. Lipsitz ◽  
Stephen E. Sallan ◽  
Virginia M. Dalton ◽  
Suzanne M. Mone ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Left Ventricular ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cardiac Abnormalities ◽  
Z Scores ◽  
Long Term Survivors ◽  
Fractional Shortening

Purpose Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare. Methods Serial echocardiograms (N = 499) were obtained from 115 doxorubicin-treated long-term survivors of childhood acute lymphoblastic leukemia (median age at diagnosis, 4.8 years; median follow-up after completion of doxorubicin, 11.8 years). Results were expressed as z scores to indicate the number of standard deviations (SDs) above (+) or below (−) the normal predicted value. Median individual and cumulative doxorubicin doses were 30 mg/m2 per dose and 352 mg/m2, respectively. Results Left ventricular fractional shortening was significantly reduced after doxorubicin therapy, and the reduction was related to cumulative dose. z scores for fractional shortening transiently improved before falling to −2.76 more than 12 years after diagnosis. Reduced fractional shortening was related to impaired contractility and increasing afterload, consequences of a progressive reduction of ventricular mass, and wall thickness relative to body-surface area. Left ventricular contractility fell significantly over time and was depressed at last follow-up in patients receiving more than 300 mg/m2 of doxorubicin. Systolic and diastolic blood pressures were below normal more than 9 years after diagnosis. Even patients receiving lower cumulative doxorubicin doses experienced reduced mass and dimension. Fractional shortening and dimension at the end of therapy predicted these parameters 11.8 years later. Conclusion Cardiac abnormalities were persistent and progressive after doxorubicin therapy. Inadequate ventricular mass with chronic afterload excess was associated with progressive contractile deficit and possibly reduced cardiac output and restrictive cardiomyopathy. The deficits were worst after highest cumulative doses of doxorubicin, but appeared even after low doses.

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